The objective of this research is to study the cardioselective peripheral noradrenergic deficiency in Lewy body synucleinopathies. Lewy body (LB) synucleinopathies such as Parkinson’s disease profounds cardiac deficiency. A study in vivo neuroimaging states about cardioselective noradrenergic lesion. A review on 18°F- dopamine emission tomographic images and later neurochemical data testing in several body organs of patients with LB synucleinopathies were observed. The function of 18° F – DA is to derive radioactivity in heart, spleen, stomach, liver, pancreas, kidneys, thyroid, and other glands and this was observed for 145 patients with LB synucleinopathies (112 PD , 33 PAF ), 74 controls, and 85 MSA patients. On a whole separate cohorts, post-mortem tissue norepinephrine data reviewed for heart, spleen, liver, kidney, pancreas, thyroid, submandibular gland, sympathetic ganglion tissue from 38 PD, 2 PAF, 5 MSA patients and 35 controls. The LB and non-LB groups did not differ in spleen liver pancreas kidney or stomach. 18°F-DA derived the Radioactivity. Hence we conclude that LB synucleinopathy group had increased myocardial norepinephrine, but consisting of normal tissue norepinephrine in other organs. After the examination on other organs it was viewed that MSA group had normal tissue norepinephrine.
Reference link- https://onlinelibrary.wiley.com/doi/10.1002/acn3.51243
