Intrathecal gene therapy as a treatment for giant axonal neuropathy
1. In this dose-escalation study, using intrathecal gene transfer with scAAV9/JeT-GAN demonstrated...
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chronic-disease
Intravascular ultrasound-guided stent insertion improves outcomes in patients with acute coronary syndrome
1. Target-vessel failure was significantly lower in the ultrasound-guided group than the...
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Perioperative Nivolumab in Resectable Lung Cancer
1. The 18-month event-free survival in the perioperative nivolumab group was 70.2% vs 50.0% in the...
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Female physicians associated with improved inpatient mortality and readmission rates
1. In this observational study, inpatients treated by a female physician had lower 30-day...
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Genomic data optimizes hematopoietic stem-cell transplantation (HSCT) timing for myelodysplastic syndromes (MDS) and improves patient outcomes
1. A decision support system using the Molecular International Prognostic Scoring System (IPSS-M)...
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Ultra-processed food consumption increases all-cause mortality
1. Consumption of ultra-processed foods was associated with modestly higher all cause mortality,...
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Intra-articular platelet-rich plasma injection does not improve knee function following anterior cruciate ligament repair
1. At 12 months, patients with anterior cruciate ligament reconstruction randomized to receive...
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Positron emission tomography-guided treatment strategy may reduce need for chemotherapy for patients with HER2+ breast cancer
1. 3-year invasive disease-free survival among the PET-based treatment group was 94.8%. 2. There...
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Remote electronic patient reported outcomes may have limited feasibility in older patients with cancer
1. Among patients on anticancer treatment with malignancy who were 75 years of age or older, the...
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Capecitabine or XELOX did not appear to improve overall survival when compared to PF in patients with advanced Esophageal Squamous Cell Carcinoma
1. Although capecitabine or XELOX did not improve overall survival when compared to PF, efficacy...
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Trastuzumab Deruxtecan in Solid Tumours Harbouring HER2 Mutations
1. The objective response rate for trastuzumab deruxtecan was 29.4%. 2. Treatment-emergent adverse...
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Minimal Residual Disease negativity after Autologous Hematopoietic Cell Transplantation with lenalidomide maintenance predicts better long-term outcomes in myeloma
1. Achieving Minimal Residual Disease (MRD) negativity at baseline before lenalidomide...
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Promising results with new oncolytic virus targeted at advanced solid tumors
1. The use of recombinant L-IFN adenovirus in patients with recurrent or refractory advanced solid...
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Low lower-limb muscle mass index with weight-bearing activity increases incidence of osteoarthritis
1. Increased incidence of radiographic knee osteoarthritis was associated with high amounts of...
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Plant-based diets may be associated with slower disease progression in men with prostate cancer
1. In a cohort of men with prostate cancer, disease progression was lower in men who had a higher...
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Higher national health expenditure correlates with better lymphoid malignancy survival rates in European countries.
1. Lymphoid malignancy survival rates in European countries correlate with natation health...
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Cardiovascular risk associated with social determinants of health at individual and area levels
1. In this cohort study, individual and area level social determinants of health (SDOH) were...
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Access to mental health and substance use treatment improved with comprehensive primary care plus program
1. In a cohort of individuals, those diagnosed with an opioid use disorder (OUD), anxiety, or...
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Prenatal opioid exposure and not associated with increased risk of neuropsychiatric disorders in children
1. In a cohort study in South Korea, prenatal opioid use did not significantly increase the risk...
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Afamitresgene autoleucel as an effective T-cell therapy for synovial sarcoma and liposarcoma
1. Overall response rate to afami-cel in both groups was 37%. 2. The majority of adverse-events...
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