Pembrolizumab enhances progression-free survival in patients with locally advanced cervical cancer
1. Progression-free survival at 24 months was higher in the pembrolizumab versus...
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chronic-disease
The addition of cisplatin to standard-of-care radiation therapy does not appear to improve progression-free survival for patients with localized recurrent endometrial cancer.
1. For patients with localized endometrial cancer recurrence, adding cisplatin to radiation...
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Gefitinib with Chemotherapy in EGFR-Mutated Lung Cancer
1. The median overall survival was 17.6 months in the gefitinib group vs 27.5 months in the...
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Low-molecular weight heparin bridging therapy safe in elderly undergoing surgery following percutaneous coronary intervention
Impact of perioperative low-molecular-weight heparin therapy on clinical events of elderly...
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Poor respiratory function is associated with greater incidence of depression
1. In a cohort of patients with varying lung function assessed through values of FVC and FEV1, and...
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Beta-blockers do not lower mortality after myocardial infarction with preserved ejection fraction
1. In this randomized controlled trial, long-term beta-blockers did not impact all-cause mortality...
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Semaglutide improves obesity-related heart failure symptoms
1. In this randomized controlled trial, semaglutide was more effective in reducing heart...
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Mitoxantrone is superior to liposomal daunorubicin in MRD (measurable residual disease)-guided treatment of AML in pediatric cases
1. Mitoxantrone enhances five-year event-free survival over liposomal daunorubicin in MRD-guided...
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Neoadjuvant chemotherapy does not appear to significantly improve disease-free survival in patients with locally advanced colon cancer
1. When compared to upfront surgery, neoadjuvant chemotherapy using mFOLFOX or CAPOX did not...
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Omitting Axillary Dissection in Breast Cancer with Sentinel-Node Metastases
1. The hazard ratio for recurrence or death comparing sentinel node biopsy only to completion...
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Novel prophylactic anticoagulation scoring tool helps stratify patients following lower limb trauma
1. The 3-month symptomatic venous thromboembolism rate was 0.7% in patients with TRiP(cast) score...
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Hepatitis E vaccine shows promising 10-year efficacy in the Chinese population
1. Overall vaccine efficacy ranged from 83.1% to 86.6% during the 10-year period. 2. Detectable...
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Intravascular image guidance during percutaneous coronary intervention lowers risk of death and myocardial infarction
1. Intravascular imaging-guided PCI significantly reduces target lesion failure compared to...
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Though associated with rising costs, the majority of publicly-funded cancer medications included in Ontario, Canada are those with substantial survival benefit
1. Roughly 65% of the cancer medication budget is allocated to treatments that provide improvement...
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Neoadjuvant Dual vs Single Checkpoint Inhibitors in High-Risk Melanoma
1. The pathological response rate had an OR of 3.16 when comparing neoadjuvant dual vs single...
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Ultrasound-guided erector spinae block and paravertebral block may prevent postherpetic neuralgia
1. Patients randomized to receive the paravertebral block (PVB) and erector spinae plane block...
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Omalizumab efficacious in treating multiple food allergies
1. In this randomized controlled trial, omalizumab was superior to placebo in increasing the...
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Initiation of medications for alcohol use disorder at hospital discharge significant improves outcomes
1. This retrospective study found that the use of medications for alcohol use disorder (MAUD)...
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Interleukin-23 autoantibodies linked to severe opportunistic infections
1. In this cohort study, neutralizing autoantibodies against interleukin-23 (anti-IL-23) were...
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Microplastics and nanoplastics linked to higher risk of cardiovascular events
1. In this prospective study, patients with carotid artery stenosis with microplastics and...
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