Gene therapy cost-effective for treating sickle cell disease in simulation models
1. In this cost analysis, compared to standard care, it was found that gene therapy for sickle...
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chronic-disease
Rates of diabetes remission and sustainability from weight loss
1. Diabetes remission was achievable for participants through weight loss by surgery or lifestyle...
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Voice-based conversational artificial intelligence may improve insulin management for diabetes
1. This randomized clinical trial demonstrated that compared with the standard of care,...
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Subcutaneous daratumumab with VRd improves progression-free survival in multiple myeloma
1. Adding subcutaneous daratumumab to VRd (bortezomib, lenalidomide, and dexamethasone)...
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Updated Outcomes of Sacituzumab Govitecan in Resistant Advanced Urothelial Carcinoma
1. The objective response rate was 28% with a complete response of 5.6% and a partial response of...
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Lower risk of adverse outcomes secondary to hypertension observed at higher ages in elderly
1. When comparing cohorts of patients above and below 75 years of age, hypertension had a greater...
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Small long term increased risks of neurodevelopmental deficits for infants born preterm
1. Moderately or late preterm infants were found to have an increased risk of neurological...
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Urgent need for improved detection of pediatric familial hypercholesterolemia worldwide
1. 92.4% of children in high-income countries had heterozygous familial hypercholesterolemia...
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Maternal autistic traits may be associated with greater risk of adverse birth outcomes
1. A cohort study found that increased maternal autistic traits were associated with a greater...
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Improved long-term survival with resynchronization versus defibrillation for heart failure
1. In this randomized controlled trial, the incidence of death was lower in heart failure patients...
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Acoramidis slows disease progression in transthyretin amyloid cardiomyopathy
1. In this randomized controlled trial, patients with transthyretin (TTR) amyloid cardiomyopathy...
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Atezolizumab in addition to bevacizumab and platinum-based chemotherapy improves survival in metastatic cervical cancer
1. The Atezolizumab group demonstrated significantly greater progression-free and overall survival...
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Worse breast cancer death rates for non-screen detected ductal carcinoma situ
1. Women with non-screen detected ductal carcinoma in situ had worse outcomes for the 25 years...
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Non-invasive ultrasound therapy safely improves aortic valve function in high-risk patients with calcified aortic stenosis
1. There was no procedure-related mortality or life-threatening events reported. 2. At the 6-month...
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Mirtazapine improves caloric intake compared to placebo in patients with advanced non-small cell lung cancer
1. While perceived appetite did not differ between study groups, patients receiving mirtazapine...
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Low dose olanzapine in non-inferior to standard dose in terms of anti-emetic effect in patients receiving emetogenic chemotherapy
1. Low dose Olanzapine (2.5 mg) demonstrated similar anti-emetic effect to standard dose...
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Cemiplimab for Kidney Transplant Recipients With Cutaneous Squamous Cell Carcinoma
1. There was no kidney rejection noted in the cemiplimab for kidney transplant recipients. 2....
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Ubrogepant is safe and effective for acute treatment of migraine prodrome
1. Absence of moderate or severe headache 24 hours following administration of treatment drug was...
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Risk factors associated with cognitive impairment development in older adults
1. This longitudinal prospective cohort study found that older adults with trajectories involving...
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Pembrolizumab and chemotherapy combination improves survival in advanced pleural mesothelioma
1. Patients in the pembrolizumab plus chemotherapy group reported a significantly greater overall...
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