Acoramidis slows disease progression in transthyretin amyloid cardiomyopathy
1. In this randomized controlled trial, patients with transthyretin (TTR) amyloid cardiomyopathy...
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chronic-disease
Atezolizumab in addition to bevacizumab and platinum-based chemotherapy improves survival in metastatic cervical cancer
1. The Atezolizumab group demonstrated significantly greater progression-free and overall survival...
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Worse breast cancer death rates for non-screen detected ductal carcinoma situ
1. Women with non-screen detected ductal carcinoma in situ had worse outcomes for the 25 years...
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Non-invasive ultrasound therapy safely improves aortic valve function in high-risk patients with calcified aortic stenosis
1. There was no procedure-related mortality or life-threatening events reported. 2. At the 6-month...
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Mirtazapine improves caloric intake compared to placebo in patients with advanced non-small cell lung cancer
1. While perceived appetite did not differ between study groups, patients receiving mirtazapine...
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Low dose olanzapine in non-inferior to standard dose in terms of anti-emetic effect in patients receiving emetogenic chemotherapy
1. Low dose Olanzapine (2.5 mg) demonstrated similar anti-emetic effect to standard dose...
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Cemiplimab for Kidney Transplant Recipients With Cutaneous Squamous Cell Carcinoma
1. There was no kidney rejection noted in the cemiplimab for kidney transplant recipients. 2....
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Ubrogepant is safe and effective for acute treatment of migraine prodrome
1. Absence of moderate or severe headache 24 hours following administration of treatment drug was...
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Risk factors associated with cognitive impairment development in older adults
1. This longitudinal prospective cohort study found that older adults with trajectories involving...
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Pembrolizumab and chemotherapy combination improves survival in advanced pleural mesothelioma
1. Patients in the pembrolizumab plus chemotherapy group reported a significantly greater overall...
Read MoreMonocyte-to-HDL ratio may be an indicator of poor endothelial dysfunction in diabetics
1. This cross-sectional study is the first to identify the monocyte-to-HDL ratio (MHR) as an indicator of poor endothelial dysfunction in a sample of diabetic patients. Evidence Rating Level: 2 (Good) Endothelial disruption and...
Read MorePerinatal depression associated with threefold risk of suicidal behaviour
1. Perinatal depression (PND) was found to be associated with a 3-fold increased risk for suicidal behaviours compared to a non-PND cohort at 18-year follow-up. 2. PND most significantly increased risk for suicidal behaviours...
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Short-stay units may be viable alternatives for admission for acute heart failure
1. This multicentre, randomized, comparative effectiveness study found that the short-stay unit...
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Prolonged rituximab maintenance therapy does not provide overall survival benefit in low-burden follicular lymphoma
1. In patients with low tumor burden follicular lymphoma (LTBFL): Rituximab maintenance therapy...
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Optimizing Subtyping-Based Therapy in Triple-Negative Breast Cancer
1. The median progression-free survival was improved with the pooled subtyping-based therapy group...
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Probiotic supplementation may improve outcomes in patients with type 2 diabetes
1. Patients with type 2 diabetes randomized to using probiotic supplements were found to have...
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Radical cure with primaquine reduces risk of Plasmodium vivax parasitaemia in patients with Plasmodium falciparum infection
1. Patients in the primaquine group reported a significant reduction in parasitemia risk at day 63...
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Mobile application communication may improve palliative care needs met in critically ill patients
1. Families randomized to having access to a mobile application that allowed them to communicate...
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Computed Tomography coronary calcium scores may predict risk of cardiovascular events in cancer patients
1. Despite lower prevalence of traditional cardiovascular risk factors, cancer patients were...
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Pembrolizumab enhances progression-free survival in patients with HER2-positive gastro-esophageal cancer
1. Progression-free survival was significantly greater among patients in the pembrolizumab group...
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