Multicancer early detection blood tests show promise but warrant further clinical evaluation
Bookmark1. One-third of patients with a cancer signal were correctly diagnosed to have cancer. 2....
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chronic-disease
Early versus delayed antihypertensive treatment in patients with acute ischaemic stroke
Bookmark1. In this randomized controlled trial, early compared to late blood pressure management...
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Adaptive resynchronization shows no benefit over conventional biventricular resynchronization in patients with heart failure
Bookmark1. All-cause mortality after 5 years was similar for patients in the adaptive and...
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Live viral vaccines safe for pediatric solid organ transplant recipients
Bookmark1. This cohort study of pediatric solid organ transplant (SOT) patients found that the...
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Spiritual well-being may be associated with improvements in pain intensity and catastrophizing in patients with chronic pain
Bookmark1. In this cross-sectional study, there was a high-level negative correlation between...
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Maintenance Olaparib Rechallenge in Platinum-Sensitive Relapsed Ovarian Cancer
Bookmark1. Median PFS was improved in the olaparib arm vs placebo, with an HR 0.57 in the BRCAm...
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Adenocarcinoma is the most prevalent lung cancer subtype and has a greater incidence rate in males than females
Bookmark1. The second greatest burden of lung cancer worldwide is attributed to squamous cell...
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Fotagliptin monotherapy with alogliptin may be effective for uncontrolled type 2 diabetes
Bookmark1. Fotagliptin, a novel dipeptidyl peptidase-4 inhibitor (DPP4-i), was found to be...
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Long-term heat exposure associated with severe maternal morbidity
Bookmark1. This retrospective cohort of singleton pregnancies found that severe maternal morbidity...
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Edoxaban does not improve outcomes in patients with atrial high-rate episodes
Bookmark1. In this randomized controlled trial, edoxaban did not significantly reduce the...
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Sodium-glucose cotransporter-2 inhibitors may decrease incidence of recurrent gout flares
Bookmark1. Over a one-year period, the incidence of recurrent gout flares in patients with gout...
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Ferric carboxymaltose does not improve heart failure with iron deficiency
Bookmark1. In this randomized controlled trial, ferric carboxymaltose was not superior to placebo...
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Camrelizumab plus rivoceranib superior to sorafenib for treatment of unresectable hepatocellular carcinoma
Bookmark1. Patients in the camrelizumab-rivoceranib group reported significantly greater...
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Adjuvant everolimus does not improve survival for patients with resected renal cell carcinoma
Bookmark1. Recurrence-free survival was significantly different between the adjuvant everolimus...
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Atezolizumab, Vemurafenib, and Cobimetinib in Melanoma With CNS Metastases
Bookmark1. Intracranial objective response rate was 42% in the BRAF V600 mutation-positive cohort...
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Computer-aided detection does not improve neoplasm detection with colonoscopy
Bookmark1. The GI-Genius neural network system did not improve the rate of detecting advanced...
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Younger onset of non-alcoholic fatty liver disease associated with greater cancer risk
Bookmark1. In this case-control study, younger age of onset of non-alcoholic fatty liver disease...
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Bundled parenting and nutrition outreach program may positively influence the developmental and nutritional outcomes of siblings of targeted children
Bookmark1. Siblings of children receiving bundled parenting and nutrition intervention had better...
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Complete revascularization reduces mortality in older adults with myocardial infarction
Bookmark1. In this randomized controlled trial, complete revascularization reduced the risk of...
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Nurse-delivered sleep restriction therapy effective for treatment of chronic insomnia
Bookmark1. Sleep restriction therapy was superior to sleep hygiene for the management of chronic...
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