Atogepant may be safe and effective for prevention of chronic migraines
Bookmark1. Monthly migraine days were significantly reduced in atogepant 30 mg twice daily and...
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chronic-disease
Mortality risk higher after the first occurrence of osteoporotic vertebral compression fractures
Bookmark1. Patients with a new diagnosis of osteoporotic vertebral compression fracture (OVCF) are...
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Low achievement of guideline-recommended diabetes targets in Chinese adults
1. In this cross-sectional study, the proportion of Chinese adults with self-reported type 2...
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High-dose oral semaglutide effectively glycemic control in patients with type 2 diabetes mellitus
Bookmark1. HbA1c reduction was dose-dependent in the semaglutide group with the greatest change...
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Combined digital intervention may be effective for osteoarthritis pain
Bookmark1. Following total knee replacement (TKR) for osteoarthritis, patients randomized to a...
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Atezolizumab is a potentially effective treatment option for patients with alveolar soft part sarcoma
Bookmark1. 37% of study patients had an objective response to treatment with atezolizumab. 2....
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Patritumab Deruxtecan in EGFR-mutated NSCLC post EGFR TKI and Chemotherapy
Bookmark1. The objective response rate was 29.8% (1% complete response, 66% partial response) with...
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Generic and brand-name fluticasone-salmeterol are equally effective in COPD management
Bookmark1. In this cohort study, using generic versus brand-name fluticasone-salmeterol was...
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Rectal cancer presentation and screening rates during the COVID-19 pandemic
Bookmark1. Despite the decrease in colonoscopies performed at the start of the COVID-19 pandemic,...
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Adjunctive antidepressant maintenance ineffective in bipolar I depression
Bookmark1. In this randomized controlled trial, adjunctive treatment with escitalopram or...
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Oral semaglutide effectively reduces bodyweight in non-diabetic adults with obesity
Bookmark1. The semaglutide 50 mg group saw a 15.1% reduction in body weight at 68 weeks compared...
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Retatrutide effectively reduces body weight in patients with obesity
Bookmark1. In this randomized controlled trial, the triple-hormone-receptor agonist retatrutide...
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NaV1.8 inhibitor VX-548 reduces acute post-operative pain
Bookmark1. In this randomized controlled trial, the elective NaV1.8 inhibitor VX-548 reduced acute...
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Baricitinib is safe and effective for treatment of refractory juvenile idiopathic arthritis
Bookmark1. Time to disease flare was significantly shorter in the placebo group versus...
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Low-grade inflammation scores can help predict 90-day outcomes after stroke
Bookmark1. This retrospective cohort study found that higher low-grade inflammation (LGI) scores...
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CRISPR-Cas9 promoting fetal hemoglobin production improves severe sickle cell disease
Bookmark1. In this randomized controlled trial, infusion of OTQ923 disrupted inhibitory HBG1 and...
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Nivolumab/Ipilimumab vs Nivolumab Alone in Advanced Cancers Other Than Melanoma
Bookmark1. Pooled overall survival and progression-free survival HR were found to be 0.95 and 0.88...
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HPV vaccination is safe and effective at 10-year follow-up
Bookmark1. In a long-term follow-up study of an earlier randomized control trial, participants...
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Concizumab reduces bleeding episodes in hemophilia patients with inhibitors
Bookmark1. In this phase three open-label randomized trial, concizumab prophylaxis reduced the...
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Statin use for primary and secondary prevention is influenced by social determinants of health
Bookmark1. In this cross-sectional study, rates of statin use for primary prevention were lower...
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