Tulisokibart Induces Clinical Remission in Moderate-to-Severely Active Ulcerative Colitis
1. In this randomized controlled trial, among patients with moderately to severely active...
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chronic-disease
Digital cognitive therapy program may be effective for alcohol use disorder
1. In this randomized clinical trial, adults with an alcohol use disorder (AUD) receiving either...
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Optical coherence tomography-guided angioplasty reduces adverse events compared to angiography guidance
1. Major cardiac events were significantly lower in the OCT-guided group compared to the...
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Phase II basket trial of dual anti-CTLA-4 and anti-PD-1 blockade in rare tumors
1. Treatment of desmoid tumours with dual anti-CTLA-4 and anti-PD-1 blockade with ipilimumab and...
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Overall Survival with Pembrolizumab in Early-Stage Triple-Negative Breast Cancer
1. The 5-year OS rate for pembrolizumab vs placebo was 86.1% vs 81.7% with HR 0.51 (significant)....
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Time-Restricted Eating May Improve Glycemic Regulation in Metabolic Syndrome
1. In this randomized controlled trial, patients with metabolic syndrome who underwent...
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Infusion with a monoclonal antibody decreases migraine frequency
1. In this randomized controlled trial, in patients diagnosed with migraine, it was found that...
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Ticagrelor monotherapy reduces bleeding risk compared to dual antiplatelet therapy for patients following coronary stenting
1. Ticagrelor was non-inferior to DAPT for the incidence of major adverse cardiovascular and...
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Semaglutide Reduces Heart Failure Events in Patients With Preserved Ejection Fraction
1. Patients in the semaglutide group reported fewer heart failure events than those in the placebo...
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Ponsegromab for the Treatment of Cancer Cachexia
1. Ponsegromab at increasing doses resulted in a mean increase in body weight compared to placebo;...
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Sedentary behaviour associated with various forms of mortality and cancers in a United Kingdom cohort
1. In two cohorts from the UK Biobank and the National Health and Nutrition Examination Survey...
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New prognostic model for hepatocellular carcinoma in chronic hepatitis B
1. In this cohort study involving noncirrhotic patients with chronic hepatitis B, a new prognostic...
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Naldemedine may be effective for opioid-induced constipation in patients with cancer
1. In a randomized double-blind placebo-controlled study, naldemedine use was associated with...
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Exoskeletal assisted walking devices currently do not demonstrate clear benefits for patients with paralysis
1. In veterans with spinal cord injuries, exoskeletons showed no clear benefits (medical, physical...
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ML Model Non-Invasively Detects Hypoglycemia During Driving
1. Machine learning (ML) models developed by Lehmann and colleagues used driving characteristics...
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Plasma biomarkers may have a role in adolescent traumatic brain injuries
1. GFAP, UCH-L1, NfL, and t-tau are all promising plasma biomarkers that show sex specific changes...
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Chronic Pain Syndromes Show No Significant Association With Quantitative Sensory Testing Modalities or Inflammatory Markers
1. Chronic pain syndromes including fibromyalgia, dry eye disease, and irritable bowel syndrome...
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Anemia is a common side effect of antiretroviral therapy for HIV
1. Patients with HIV treated with antiretroviral therapy (ART) have a 31.5% chance of being...
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Belzutifan versus Everolimus for Advanced Renal-Cell Carcinoma
1. Median PFS (5.6 months vs 5.6 months) and median OS (21.4 months vs 18.1 months) were similar...
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Individuals with disorders of consciousness can perform cognitive tasks
1. In a large cohort of individuals with disorders of consciousness exhibiting no observable...
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