Synergistic interaction between risk burden and genetics for atrial fibrillation development
1. In a large prospective study, risk burden and genetic predisposition acted synergistically to...
Read More
chronic-disease
Dementia is associated with high rates of sleep-related breathing disorders
1. In this meta-analysis, it was found that the pooled prevalence of sleep-related breathing...
Read More
Active monitoring, prostatectomy, and radiotherapy as treatment options for localized prostate cancer result in similar prostate-cancer-mortality
1. Localized prostate cancer mortality remains similar between groups receiving prostatectomy,...
Read More
Nirogacestat, a γ-Secretase Inhibitor for Desmoid Tumors
1. There is a 71% lower risk of disease progression or death in the nirogacestat group than in the...
Read More
Exercise and caloric restriction reduce visceral fat in overweight adults
1. In this systematic review and meta-analysis, both exercise and caloric restriction were...
Read More
Sotorasib superior to docetaxel for treatment of KRASG12C-positive non-small-cell lung cancer
1. Patients allocated to the sotorasib group reported increased progression-free survival compared...
Read More
Age and genetics as risk factors for the development of atrial fibrillation
1. In this prospective cohort study, age was found to be the most prominent risk factor for the...
Read More
Etranacogene dezaparvovec gene therapy reduces bleeding in severe hemophilia B
1. Etranacogene dezaparvovec gene therapy was more effective than prophylactic factor IX infusion...
Read More
Sodium bicarbonate does not prevent declining kidney function in kidney transplant recipients
1. The mean eGFR slope was comparable among patients allocated to sodium bicarbonate and placebo...
Read More
Ultrasound ablation of globus pallidus reduces Parkinson’s disease motor symptoms
1. In this randomized controlled trial, ultrasound ablation of the globus pallidus was associated...
Read More
Sodium-glucose cotransporter-2 inhibitors are of intermediate or low economic value in the treatment of heart failure with preserved ejection fraction
1. Sodium-glucose cotransporter-2 inhibitors (SGLT2-I) in combination with standard of care were...
Read More
Secukinumab reduces symptoms of moderate-to-severe hidradenitis suppurativa
1. Patients receiving secukinumab every 2-weeks showed superior clinical response rates compared...
Read More
Black patients with pulmonary fibrosis may have worse outcomes compared to other populations
1. In this retrospective cohort study, Black patients with pulmonary fibrosis (PF) were found to...
Read More
Bedaquiline-linezolid regimen noninferior to standard treatment for tuberculosis
1. In this randomized control trial, an eight-week bedaquiline-linezolid regimen was noninferior...
Read More
Pituitary microadenomas exhibit slow growth and may require less frequent MRI surveillance
1. In this retrospective cohort study, two-thirds of incidental pituitary microadenomas remained...
Read More
Combination therapy with alisterib and fulvestrant may be clinically advantageous in the treatment of endocrine-resistant advanced breast cancer
1. Compared to alisertib alone, adding alisertib to fulvestrant did not increase objective tumour...
Read More
Paid-sick-leave mandates contribute to increased cancer screening in the United States
1. Mandated and available paid-sick-leave resulted in increased colorectal and breast cancer...
Read More
Neoadjuvant–Adjuvant vs. Adjuvant-Only Pembrolizumab in Advanced Melanoma
1. Event-free survival at 2 years was longer in the neoadjuvant-adjuvant group vs the...
Read More
School nutritional quality programs associated with lower BMI in children
1. In a retrospective cohort study, the implementation of policies to strengthen nutritional...
Read More
Endovascular ultrasound renal denervation associated with lower ambulatory systolic blood pressure in patients with hypertension – The RADIANCE II randomized clinical trial
1. In this sham-controlled, randomized clinical trial, among 224 patients with hypertension,...
Read More