Selpercatinib showed promising clinical activity in tumour-agnostic patients with RET fusion-positive cancers other than thyroid and lung cancer
1. Objective response rate was 43.9%. Patients treated with selpercatinib also experienced...
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chronic-disease
Glargine and liraglutide are effective glucose-lowering medications in type 2 diabetes
1. Compared to sitagliptin and glimepiride, glargine and liraglutide were more effective in...
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More permissive parameters for active surveillance eligibility is potentially possible in slow-growing thyroid cancers
1. Patients in the active surveillance group who had forgone surgery had no difference in survival...
Read MoreIncreased pre-chemotherapy inflammatory biomarkers (IL-6 and CRP) correlated to increased risk of frailty post-chemotherapy in older breast cancer patients
1. 25.8% of patients receiving chemotherapy for breast cancer experienced worsening frailty status. 2. Patients with both biomarkers (IL-6 and CRP) elevated before chemotherapy had a significantly higher risk of decline in...
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Dapagliflozin slows disease progression in patients with heart failure with preserved ejection fraction
1. Dapagliflozin was shown to reduce the risk of disease progression and cardiovascular death in...
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Tofersen does not improve ALS symptoms in patients with SOD1 mutations
1. In patients with amyotrophic lateral sclerosis (ALS) and superoxide dismutase 1 (SOD1)...
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Effectiveness of stand-alone telephone-delivered intervention for reducing problem alcohol use
1. In this randomized controlled trial, in participants with problem alcohol use, individuals in...
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Occupational and leisure physical activity may have varying effects on inflammation
1. Lower leisure time physical activity and higher occupational physical activity were associated...
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Unsupervised online yoga transiently improves symptoms in patients with knee osteoarthritis
1. Compared to a control group, patients with knee osteoarthritis who engaged in online yoga had...
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Dupilumab plus topical corticosteroids are effective in the treatment of childhood atopic dermatitis
1. By week 16, 28% of patients in dupilumab reported clear or almost clear skin (IGA 0-1) compared...
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Lower limb osteoarthritis may be more prevalent in retired Olympians
1. In this study, one in four retired Olympians reported physician-diagnosed osteoarthritis (OA),...
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Risk of cardiovascular pathology determined using advanced cardiovascular imaging limited by heterogeneity amongst patients with human immunodeficiency virus
1. Prevalence of moderate coronary disease ranged from 0-52% amongst patients with human...
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Sleep surgery for obstructive sleep apnea may decrease blood pressure
1. In this systematic review and meta-analysis, surgeries for sleep apnea showed improvements in...
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Adjuvant pembrolizumab increased disease-free survival in completely resected, PD-L1 unselected non-small-cell lung cancer patients
1. Adjuvant pembrolizumab significantly improved disease-free survival in comparison to placebo in...
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Neoadjuvant celmiplimab is associated with pathologic response in cutaneous squamous cell carcinoma
1. After neoadjuvant treatment with celmiplimab, half of the patients were found to have a...
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Summary Elixhauser score interally validated for mortality prediction in older adults
1. The Summary Elixhauser (S-Elixhauser) comorbidity score is internally validated for predicting...
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Study reports improvement in pediatric liver transplant outcomes over past decades
1. In approximately 14,000 pediatric patients across Europe who received a liver transplant...
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Low prevalence of adrenal tumors in the general adult screening population
1. The prevalence of adrenal tumors in the general adult screening population is 1.4%. 2. The...
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Impact of ultrasonographic blind spots for early-stage hepatocellular carcinoma during surveillance
1. Hepatocellular carcinoma (HCC) tumours located in ultrasound (US) blind spots were associated...
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Altered carbohydrate and protein intake may affect sleep quality
1. In this systematic review, long-term increased carbohydrate intake improved rapid eye movement...
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