Germline Mutations in CIDEB Confer Protection from Liver Disease
1. Rare mutations in CIDEB are associated with a decreased risk of developing liver cirrhosis. 2....
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chronic-disease
Nonsteroidal Anti-Inflammatory Drug exposure associated with development of microscopic colitis
1. Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) were independently associated with the...
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Litifilimab associated with reduced disease severity in patients with cutaneous lupus erythematosus
1. Litifilimab significantly decreased cutaneous lupus erythematosus (CLE) disease area and...
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Gout flares associated with a transient increase in subsequent risk of cardiovascular events
1. Amongst patients with gout, those who experienced a cardiovascular event were likely to have...
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Supplemental vitamin D does not reduce risk of fractures in older adults
1. There were no significant differences in total, non-vertebral, or hip fractures between the...
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Atherosclerotic risk factors associated with stroke in adulthood present from childhood and increase with age
1. Atherosclerotic risk factors associated with stroke later in life were present in children, but...
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Vaccination after recovery from COVID-19 reduced rate of reinfection by half
1. Completion of the primary vaccination series against COVID-19 amongst individuals who had...
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Comprehensive telehealth intervention effective for reducing HbA1c in poorly controlled diabetes
1. In this randomized controlled trial, a comprehensive telehealth intervention was linked to a...
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Methotrexate reduces functional burden of disease in patients with arthralgia at-risk of developing rheumatoid arthritis
1. Compared to placebo, methotrexate did not significantly reduce the risk of the development of...
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Association between early left ventricular ejection fraction improvement after transcatheter aortic valve replacement and 5-Year clinical outcomes
1. In this retrospective cohort study, left ventricular ejection fraction (LVEF) improvement at 30...
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Association Between CYP Metabolizer Phenotypes and SSRI Induced Weight Gain
1. In this retrospective cohort study, in patients prescribed citalopram, poor/intermediate...
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Demographic trends in heart failure related mortality over past 2 decades
1. In this retrospective cohort analysis, heart failure (HF) related mortality has increased in...
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Dapagliflozin associated with reduced risk of cardiovascular and kidney outcomes irrespective of background use of cardiovascular medications
1. In this secondary analysis of the DECLARE-TIMI 58 trial, among 17,160 patients, dapagliflozin...
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Exposure to macrolides in children may be potentially associated with sensorineural hearing loss
1. Patients under 18 years of age with sensorineural hearing loss (SNHL) had a higher odds of...
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Use of left ventricular assist device associated with increased mortality compared to intra-aortic balloon pump in patients with cardiogenic shock from myocardial infarction
1. Use of an intravascular left ventricular assist device was associated with higher mortality in...
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Omecamtiv mecarbil not associated with improved exercise capacity compared with placebo in patients with chronic heart failure with reduced ejection fraction
1. In this randomized controlled trial, among 276 patients with chronic heart failure with reduced...
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Alcohol recovery narratives are dynamic and may be composed of multiple dimensions
1. In this study, the eight principle narrative dimensions related to alcohol recovery identified...
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Pembrolizumab plus chemotherapy improved survival in a subgroup of triple-negative metastatic breast cancer
1. Pembrolizumab plus chemotherapy for triple-negative breast cancer significantly increased PFS...
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Low-dose AAVS3 gene therapy is efficacious for treating patients with hemophilia B
1. Hemophilia B patients treated with the adeno-associated virus (AAV) gene therapy produced...
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Wishes and needs of nursing home residents are heterogeneous and comprise various themes
1. Wishes and needs of nursing home residents were assigned to 12 different themes, the most...
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