Bridging therapy is superior to direct thrombectomy within 4.5 hours of acute ischemic stroke
1. Fewer patients in the direct thrombectomy achieved functional independence at 90 days compared...
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chronic-disease
Plasma p-tau217 is an accurate plasma biomarker of pathologic cerebral changes in patients with Down Syndrome
1. Plasma biomarkers, including p-tau217, were found to accurately detect cerebral changes...
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High dose dexamethasone does not improve survival in patients with hypoxemic respiratory failure due to COVID-19
1. High dose dexamethasone was nonsuperior in regards to 60-day survival outcomes as compared with...
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Comparisons of invasive versus conservative management in chronic kidney disease in the ISCHEMIA-CKD trials
1. Following invasive or conservative management of chronic coronary disease, patients with...
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Community-based and health-care based smoking cessation intervention models have similar efficacy
1. There was no significant difference in smoking cessation between healthcare-based and...
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Relugolix combination therapy is efficacious for endometriosis-associated pain
1. Relugolix combination therapy significantly reduced endometriosis-associated dysmenorrhea and...
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APOEε4 genotype may increase risk of chronic traumatic encephalopathy following repetitive head impact
1. A cross sectional study of postmortem brain specimens from individuals with a history of...
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Health system-based care associated with better treatment use and high rates of tobacco abstinence at 3 months post-discharge in hospitalized smokers
1. In this randomized controlled trial of 1409 hospitalized patients who smoke, the...
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FOLFOX combined with nivolumab and trastuzumab in ERBB2-positive esophagogastric adenocarcinoma is an emerging therapy option
1. Overall survival rate at 12 months for the FOLFOX arm and ipilimumab arm was 70% and 57%,...
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Adding atezolizumab to standard of care treatment for human epidermal growth factor receptor 2 (HER2) positive early breast cancer does not improve pathologic response outcomes
1. The pathologic response rate was similar in the atezolizumab treatment group as compared to...
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Sickle cell trait associated with preexisting kidney comorbidities and increased COVID-19 mortality
1. Sickle cell trait was associated with increased COVID-19 mortality and various preexisting...
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Cognitive behavioral therapy efficacious for treatment of comorbid posttraumatic headache and posttraumatic stress disorder symptoms among US veterans
1. Among US military veterans with posttraumatic headache and comorbid posttraumatic stress...
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Early exposure to allergenic foods may reduce incidence of long-term food allergy
1. Prevalence of food allergy at 36 months was greatest in the skin intervention group and lowest...
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Lisocabtagene maraleucel improves survival for relapsed or refractory large B-cell lymphoma
1. Median event-free survival in the liso-cel group was significantly greater than in the...
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ACKR1 variant increases risk of azathioprine-related hematopoietic toxicity
1. Patients with the ACKR1 variant (CC genotype) had an elevated risk of azathioprine...
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Heavy smoking is associated with visual field loss in glaucoma
1. In a cohort of about 500 eyes with primary open-angle glaucoma (POAG), higher smoking intensity...
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Post-operative opioids at discharge increase adverse events without improving pain management
1. There was no significant difference in pain reduction among patients in the opioid and...
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United States medical cannabis registration increased significantly between 2016 and 2020
1. Registration for medical cannabis increased 4.5 times from 2016 to 2020 in the United States,...
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Fazirsiran reduces Z-AAT protein production in alpha1-antitrypsin deficiency
1. Fazirsiran is associated with a signifcant reduction of Z-AAT protein concentration in the...
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2 Minute Medicine Rewind June 27, 2022
Multispecies Probiotic for the Prevention of Antibiotic-Associated Diarrhea in Children: A...
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