Rare APOE missense variants V236E and R251G associated with substantial reduction in risk of Alzheimer disease
1. APOE ε3 (V236E) and APOE ε4 (R251G), 2 rare missense genetic variants, both had a substantial...
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chronic-disease
Effectiveness of a digital intervention versus alcohol information for online help-seekers in Sweden
1. Among a group of risky drinkers seeking online help in Sweden, a digital alcohol intervention...
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Decline in gait speed paired with domain-specific cognition decline may be a useful screening assessment for dementia
1. A decline in gait speed paired with domain-specific cognitive decline proved to be strongly...
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Subacromial balloon spacer not effective for management of irreparable rotator cuff tears
1. The control group (debridement-only) reported better clinical outcomes at 12 months compared to...
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Quality Improvement Initiative Improves Use of Ventilator Alarms Among Children With Chronic Respiratory Failure
1. Using a stepwise, interdisciplinary approach, an algorithm was developed to improve the rates...
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Unmarried status associated with an increased risk of mortality in Asian populations
1. This cohort study found that among 623,140 individuals participating in the Asia Cohort...
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Late and moderate preterm birth associated with increased cardiometabolic risk scores in young children
1. This retrospective cohort study using the TARGet Kids! Cohort demonstrated that late and...
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Medical cannabis provides little improvement to sleep in chronic pain patients
1. In this systematic review and meta-analysis, medical cannabis and cannabinoids versus placebo...
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Alzheimer disease in individuals with Down syndrome has similar variability in age of onset and mortality rate as autosomal dominant forms
1. This systematic review and meta-analysis demonstrated that the onset of Alzheimer disease in...
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Early onset Lewy Body Dementia is more clinically distinct from Alzheimer Dementia than late onset Lewy Body Dementia
1. Select features distinguish early-onset Lewy Body Dementia from early-onset Alzheimer dementia,...
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Mediterranean diet superior to low-fat diet in secondary prevention of cardiovascular events
1. Fewer composite cardiovascular events were seen in patients on a Mediterranean diet compared to...
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Pelvic lymph node radiotherapy and androgen deprivation therapy augment progression-free status following prostatectomy
1. 5-year progression-free status was greatest in group 3 (triple therapy) and lowest in group 1...
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Long-acting cabotegravir significantly decreases incidence of HIV compared to daily oral tenofovir
1. Cabotegravir was shown to be superior to TDF-FTC in preventing HIV infection in women. 2. Both...
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Meditation may provide medical benefit for various health outcomes
1. Meditative therapies appear to be more beneficial for improving sleep quality, fatigue...
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Imiquimod noninferior to surgery in management of vulvar high-grade squamous intraepithelial lesions
1. Complete clinical response at 6 months was similar in both the topical imiquimod and surgery...
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CT associated with lower complication risks than invasive coronary angiography
1. In patients with stable chest pain and intermediate pretest probability of coronary artery...
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Fourth BNT162b2 vaccine dose provides short-term effectiveness against Covid-19 related outcomes
1. Patients receiving the fourth dose of BNT162b2 (Pfizer-BioNTech) showed reduced rates of...
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Dapagliflozin efficacious and safe in treating heart failure
1. Dapagliflozin reduced the risk of worsening heart failure or cardiovascular death regardless of...
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Canadian Syncope Risk Score demonstrates international external validation
1. The Canadian Syncope Risk Score was superior when compared to the Osservatorio Epidemiologico...
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Adding mask recommendation did not significantly reduce the SARS-CoV-2 infection rate
1. Adding a mask recommendation to other public measures did not reduce the SARS-Cov-2 infection...
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