chronic-disease

1. Pathogenic variants of BRCA1 or BRCA2 are associated with an increased risk of pancreatic and stomach cancer in both sexes 2. Only BRCA2 carriers have an increased risk of prostate cancer Evidence Rating Level: 2 (Good) Study Rundown: Pathogenic variants (PVs) of BRCA1 and BRCA2 are known to be associated with an increased risk […]

1. Extreme prematurity was associated with an increased prevalence of visual and ocular deficits, suggesting children born extremely preterm may have residual ophthalmic sequelae persisting into adulthood. 2. These findings emphasized the need for screening and management of any deficits as they evolve long-term at a population-level. Evidence Rating Level: 2 (Good) Study Rundown: Although […]

1. In very young children with type 1 diabetes, a hybrid closed-loop therapy provided significantly improved glycemic children. 2. The hybrid closed-loop therapy did not significantly increase the time spent in hypoglycemia in very young children with type 1 diabetes. Evidence Rating Level: 1 (Excellent) Study Rundown: In very young children, managing Type 1 Diabetes […]

1. Treatment with alectinib reduced CNS lesion sizes and significantly improved symptoms, ECOG performance scores and requirements for mannitol and corticosteroids in patients with metastases from non-small cell lung cancer. Evidence Level Rating: 2 (Good) Central nervous system metastases are highly prevalent in patients with ALK gene mutations driving advanced non-small cell lung cancer despite […]