Emergency departments likely overprescribing opioids for acute pain
1. In this cohort study, majority of the participants did not use all of the opioids prescribed to...
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chronic-disease
Vimseltinib may be promising in treating symptomatic tenosynovial giant cell tumour
1. Tumor response rate at 25 weeks was significantly greater in vimseltinib than placebo. 2. Most...
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Intravenous tenecteplase shows no benefit in minor ischemic stroke with intracranial occlusion
1. Return to baseline function was comparable in tenecteplase and standard-of-care groups. 2. More...
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Multi-Organ Immune-related Adverse Events from Immune Checkpoint Inhibitors
1. Co-occurrences could be clustered together into 7 clusters based on the predominant organ...
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Benralizumab associated with histologic response in eosinophilic esophagitis
1. In this randomized controlled trial, benralizumab, an anti-interleukin-5 receptor (anti-IL-5R)...
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Tisotumab Vedotin as Second or Third-Line Therapy for Recurrent Cervical Cancer
1. Median overall survival was 11.5 months in the tisotumab vedotin group and 9.5 months in the...
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Oral sebetralstat provides early symptom relief for hereditary angioedema attacks
1. In this randomized controlled trial, oral sebetralstat provided faster times to the beginning...
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Web-based cognitive behavioural therapy may be effective for treatment of bulimia nervosa
1. Patients with bulimia nervosa randomized to receive web-based cognitive behavioural therapy...
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Financial incentives may be a viable option to promote smoking cessation
1. Incentivizing smoking cessation with financial rewards increased the likelihood of cessation...
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Poor cardiovascular health is a risk factor for female infertility
1. Cardiovascular health and infertility are negatively correlated with physical activity, BMI,...
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Periodontitis in patients with diabetes and its association with diabetes-related complication
1. Periodontitis has a strong association with Type 2 Diabetes and is exacerbated by poor glycemic...
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Immunotherapy-Based Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer
1. The complete response rates (pathological and clinical) were similar (~55%) in both groups. 2....
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Poor sleep and elevation of liver function biomarkers may be predictive of liver cancer
1. Unhealthy sleep, as well elevations of liver enzymes and decreased levels of albumin and liver...
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Metformin Linked to Lower Risk of Cardiometabolic Diseases, Cardiometabolic Mortality, and All-Cause Mortality in Cancer Survivors
1. Among US cancer survivors, metformin was associated with a lower risk of cardiometabolic...
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Serum interleukins may be elevated in patients with obsessive-compulsive disorder
1. Serum interleukin-1β (IL-1β) and interleukin-6 (IL-6) levels were higher in...
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Comparison of hip fracture risk assessment tools for elderly patients
1. Femoral neck bone mineral density (FNBMD) alone discriminated 5-year hip fracture risk at least...
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Subcutaneous amivantamab with lazertinib is non-inferior to intravenous administration, with fewer adverse reactions
1. Subcutaneous amivantamab combined with lazertinib was non-inferior to intravenous amivantamab...
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Amivantamab and Lazertinib in Untreated EGFR-Mutated Advanced NSCLC
1. The progression-free survival between the amivantamab–lazertinib group (23.7 months) and the...
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Anti-CD38 monoclonal antibody improves platelet counts in immune thrombocytopenia
1. In this randomized controlled trial, CM313, an anti-CD38 monoclonal antibody therapy, was...
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APOE3 Christchurch heterozygosity may delay cognitive impairment in Alzheimer’s disease
1. Carriers of the E280A variant of presenilin 1 (PSEN1E280A) who were heterozygous for the...
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