Trastuzumab Deruxtecan in Solid Tumours Harbouring HER2 Mutations
1. The objective response rate for trastuzumab deruxtecan was 29.4%. 2. Treatment-emergent adverse...
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chronic-disease
Minimal Residual Disease negativity after Autologous Hematopoietic Cell Transplantation with lenalidomide maintenance predicts better long-term outcomes in myeloma
1. Achieving Minimal Residual Disease (MRD) negativity at baseline before lenalidomide...
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Promising results with new oncolytic virus targeted at advanced solid tumors
1. The use of recombinant L-IFN adenovirus in patients with recurrent or refractory advanced solid...
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Low lower-limb muscle mass index with weight-bearing activity increases incidence of osteoarthritis
1. Increased incidence of radiographic knee osteoarthritis was associated with high amounts of...
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Plant-based diets may be associated with slower disease progression in men with prostate cancer
1. In a cohort of men with prostate cancer, disease progression was lower in men who had a higher...
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Higher national health expenditure correlates with better lymphoid malignancy survival rates in European countries.
1. Lymphoid malignancy survival rates in European countries correlate with natation health...
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Cardiovascular risk associated with social determinants of health at individual and area levels
1. In this cohort study, individual and area level social determinants of health (SDOH) were...
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Access to mental health and substance use treatment improved with comprehensive primary care plus program
1. In a cohort of individuals, those diagnosed with an opioid use disorder (OUD), anxiety, or...
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Prenatal opioid exposure and not associated with increased risk of neuropsychiatric disorders in children
1. In a cohort study in South Korea, prenatal opioid use did not significantly increase the risk...
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Afamitresgene autoleucel as an effective T-cell therapy for synovial sarcoma and liposarcoma
1. Overall response rate to afami-cel in both groups was 37%. 2. The majority of adverse-events...
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Pembrolizumab enhances progression-free survival in patients with locally advanced cervical cancer
1. Progression-free survival at 24 months was higher in the pembrolizumab versus...
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The addition of cisplatin to standard-of-care radiation therapy does not appear to improve progression-free survival for patients with localized recurrent endometrial cancer.
1. For patients with localized endometrial cancer recurrence, adding cisplatin to radiation...
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Gefitinib with Chemotherapy in EGFR-Mutated Lung Cancer
1. The median overall survival was 17.6 months in the gefitinib group vs 27.5 months in the...
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Low-molecular weight heparin bridging therapy safe in elderly undergoing surgery following percutaneous coronary intervention
Impact of perioperative low-molecular-weight heparin therapy on clinical events of elderly...
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Poor respiratory function is associated with greater incidence of depression
1. In a cohort of patients with varying lung function assessed through values of FVC and FEV1, and...
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Beta-blockers do not lower mortality after myocardial infarction with preserved ejection fraction
1. In this randomized controlled trial, long-term beta-blockers did not impact all-cause mortality...
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Semaglutide improves obesity-related heart failure symptoms
1. In this randomized controlled trial, semaglutide was more effective in reducing heart...
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Mitoxantrone is superior to liposomal daunorubicin in MRD (measurable residual disease)-guided treatment of AML in pediatric cases
1. Mitoxantrone enhances five-year event-free survival over liposomal daunorubicin in MRD-guided...
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Neoadjuvant chemotherapy does not appear to significantly improve disease-free survival in patients with locally advanced colon cancer
1. When compared to upfront surgery, neoadjuvant chemotherapy using mFOLFOX or CAPOX did not...
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Omitting Axillary Dissection in Breast Cancer with Sentinel-Node Metastases
1. The hazard ratio for recurrence or death comparing sentinel node biopsy only to completion...
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