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Critical Care General

Neuroprognostication in neonatal encephalopathy due to presumed hypoxic-ischemic encephalopathy.

Apr 07, 2025

Over the last two decades, significant progress has been made in the management of neonatal encephalopathy due to presumed hypoxic-ischemic encephalopathy. One key area that requires improvement is ti...

Prognostic implications of functional tricuspid regurgitation in asymptomatic degenerative mitral regurgitation.

Mar 24, 2025

Functional tricuspid regurgitation (FTR) associated with degenerative mitral regurgitation (DMR) accentuates the severity of heart failure and is a marker of poor prognosis. Little is known about FTR ...

Safety and efficacy of rilzabrutinib vs placebo in adults with immune thrombocytopenia: the phase 3 LUNA3 study.

Mar 17, 2025

Rilzabrutinib is a covalent, reversible BTK inhibitor with multiple mechanisms targeting key immune thrombocytopenia (ITP) disease pathophysiology. The phase 3 LUNA3 study in previously treated adults...

ACEi and ARBs as Primary Prevention of Cancer Therapy-Related Cardiomyopathy in Patients Undergoing Chemotherapy with Anthracyclines: A Systematic Review and Meta-Analysis.

Mar 17, 2025

Anthracyclines treat a myriad of malignancies; however, they are known to lead to cancer therapy-related cardiomyopathy (CTRC). Randomized controlled trials (RCTs) evaluating the role of angiotensin c...

Siderophore-Functionalized Nanodrug for Treating Antibiotic-Resistant Bacteria.

Feb 03, 2025

The development of nanodrugs targeting multidrug-resistant bacteria, while sparing the beneficial constituents of the microbiome, has emerged as a promising approach to combat disease and curb the ris...

Dihydromyricetin Protects Against Hypoxia/Reoxygenation Injury in Cardiomyocytes by Activating miR-34a-Mediated Notch1 Pathway.

Jan 27, 2025

Dihydromyricetin (Dih), a naturally occurring flavonoid, has been identified to exert a protective effect against ischemia/reperfusion injury. However, the detailed mechanisms remain unclear. Here we ...

Changes in cerebrovascular reactivity as a marker of cognitive impairment risk: a transcranial Doppler study.

Jan 27, 2025

Post-stroke cognitive impairment (PSCI) and dementia affect short- and long-term outcome after stroke and can persist even after recover from a physical handicap. The process underlying PSCI is not ye...

Does oral hygiene prevents nosocomial infections in hospitalized patients? A systematic review and meta-analysis.

Jan 27, 2025

This study aimed to evaluate the impact of oral hygiene (OH) with chlorhexidine (CHX) on the evolution of nosocomial infections (NI).Electronic searches were carried out in PubMed, Scopus, Cochrane Li...

Morbidity and mortality associated with ESBL Klebsiella pneumoniae infection in different administration routes in albino rats.

Jan 13, 2025

Klebsiella pneumoniae is a non-motile, encapsulated, environmental gram-negative bacterium. Once the bacteria have infiltrated the body, they can display substantial degrees of resistance to drugs and...

Abdominal kaposiform hemangioendothelioma presenting as volvulus and recurring intestinal obstruction in a neonate: a case report.

Dec 23, 2024

Kaposiform hemangioendothelioma is a rare vascular tumor primarily occurring in infants and children. The most common sites for kaposiform hemangioendothelioma are extremities, with very few cases of ...

Faecal metaproteomics analysis reveals a high cardiovascular risk profile across healthy individuals and heart failure patients.

Dec 23, 2024

The gut microbiota is a crucial link between diet and cardiovascular disease (CVD). Using fecal metaproteomics, a method that concurrently captures human gut and microbiome proteins, we determined the...

Robotic median arcuate ligament release prior to pancreatoduodenectomy.

Dec 09, 2024

Celiac artery stenosis presents significant risks in pancreatoduodenectomy (PD), including elevated incidences of postoperative hepatic ischemia and clinically relevant pancreatic fistulae. Addressing...

Increasing incidence of concussion and head injury due to electric biking: a 10-year sex and age-specific analysis of national injury data.

Dec 09, 2024

Electric biking (e-biking) is a rapidly growing recreation, sport, and mode of transportation that often presents to emergency departments (EDs) with high-impact head injuries. This study aimed to eva...

Impact of postoperative infectious complications on long-term prognosis after esophagectomy.

Dec 02, 2024

Postoperative complications have been reported to be a risk factor for worse oncologic outcomes in patients with esophageal cancer. However, the impact of postoperative complications on prognosis afte...

Adolescent Blood Pressure and Early Age Stroke.

Nov 18, 2024

Underdiagnosis of relevant risk factors has contributed to the increasing stroke incidence in young adults. Blood pressure cut-off values for adolescents are neither sex specific nor based on cardiova...

Spinal cord stimulation induces Neurotrophin-3 to improve diabetic foot disease.

Nov 18, 2024

Low-extremity ischemic disease is a common complication in diabetic patients, leading to reduced quality of life and potential amputation. This study investigated the therapeutic effect of spinal cord...

Differences in Pharmacological Treatment of Heart Failure Among Persons with or without Major Cognitive Disorder: A Cross-Sectional Study Based on National Registries in Sweden.

Nov 04, 2024

Comorbidities are common among older people, and during the last decade, a strong association between heart failure (HF) and cognitive impairment has been found. As much as 40-50% of individuals with ...

Characteristics, clinical care, and outcomes of sepsis among patients boarding in the emergency department.

Oct 28, 2024

Patients who first meet clinical criteria for sepsis while boarding in the emergency department (ED) may not receive optimal sepsis care.Assess the association between ED boarding status and sepsis qu...

Barriers to Delivering Concussion Education: Identifying Opportunities for Change Through the Capability, Opportunity, Motivation, Behavior (COM-B) Model.

Oct 28, 2024

This study aimed to describe barriers athletic trainers (ATs) face to implementing expert recommendations for improving athletes' concussion care-seeking behavior. We distributed an electronic survey ...

The effects of nutrition on mesenteric oxygenation among neonates with neonatal encephalopathy: a randomized clinical trial.

Oct 21, 2024

We aimed to evaluate the effects of minimal enteral nutrition (MEN) on mesenteric blood flow and oxygenation with Doppler USG and Near Infrared Spectroscopy (NIRS) during therapeutic hypothermia (TH) ...

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