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Critical Care General

CT features of coronavirus disease 2019 (COVID-19) with an emphasis on the vascular enlargement pattern.

Dec 17, 2020

The vascular enlargement (VE) pattern differs from previously described imaging patterns for pneumonia. This study aimed to investigate the incidence, computed tomography (CT) characteristics, and dia...

High Thrombin Generation after Acute Ischemic Stroke or Transient Ischemic Attack Is Associated with a Reduced Risk of Recurrence: An Observational Cohort Study.

Dec 17, 2020

Thrombin is increasingly recognized to be of importance for cardiovascular disease. The aim of this study was to investigate the prognostic value of thrombin generation variables in a cohort of patien...

The Relationship Between Asthma and Cardiovascular Disease: An Examination of the Framingham Offspring Study.

Dec 17, 2020

Although asthma has been suggested as a risk factor for cardiovascular disease (CVD), robust longitudinal evidence of this relationship is limited.Using Framingham Offspring Cohort data, we sought to ...

Mortality Prediction of the CHADS-VASc Score, the HAS-BLED Score, and Their Combination in Anticoagulated Patients with Atrial Fibrillation.

Dec 17, 2020

Atrial fibrillation (AF) is associated with increased mortality, predictors of which are poorly characterized. We investigated the predictive power of the commonly used CHADS-VASc score (congestive he...

Therapeutic index for local infections score (TILI): a new diagnostic tool.

Dec 17, 2020

Local wound infections are a major challenge for patients and health professionals. Various diagnostic and therapeutic options are available. However, a generally accepted standard is still lacking in...

PD-1 blockade improves Kupffer cell bacterial clearance in acute liver injury.

Dec 17, 2020

Acute liver failure (ALF) patients display systemic innate immune suppression and increased susceptibility to infections. PD-1 expression by macrophages has been associated with immune suppression dur...

A roadmap from single-cell transcriptome to patient classification for the immune response to trauma.

Dec 17, 2020

Immune dysfunction is an important factor driving mortality and adverse outcomes after trauma but remains poorly understood, especially at cellular level. To deconvolute trauma-induced immune response...

Geriatric polytrauma patients should not be excluded from aggressive injury treatment based on age alone.

Dec 17, 2020

Age in severely injured patients has been increasing for decades. Older age is associated with increasing mortality. However, morbidity and mortality could possibly be reduced when accurate and aggres...

Does lack of brain injury mean lack of cognitive impairment in traumatic spinal cord injury?

Dec 17, 2020

Traumatic spinal cord injury (tSCI) has implications in many areas, including cognitive functioning. Findings regarding cognitive problems in people with SCI are inconsistent, presumably due to multip...

Reliability and validity of the Rowland Universal Dementia Assessment Scale for patients with traumatic brain injury.

Dec 17, 2020

Objective and accurate cognitive assessment scales are essential for guiding cognitive rehabilitation following traumatic brain injury (TBI). The aim of this study was to evaluate the reliability and ...

Electrocardiographic T-wave morphology and risk of mortality.

Dec 17, 2020

Electrocardiographic T-wave morphology is used in drug safety studies as an adjunct to the QT interval, but few measurements of T-wave morphology can be interpreted in clinical practice. Morphology co...

Cost of inpatient heart failure care and 30-day readmissions in the United States.

Dec 17, 2020

Heart failure hospitalizations are a major financial cost to healthcare systems. This study aimed to evaluate the costs associated with inpatient hospitalization.Patients with a primary diagnosis of h...

Age and Outcome after Endovascular Treatment in Anterior Circulation Large-Vessel Occlusion Stroke: ETIS Registry Results.

Dec 17, 2020

Increasing patient age has been identified in clinical trials as a poor prognostic factor for functional independence after endovascular treatment (EVT) for acute ischemic stroke. These findings may n...

Heart failure is independently associated with white matter lesions: insights from the population-based LIFE-Adult Study.

Dec 17, 2020

White matter lesions (WML) are common structural alterations in the white matter of the brain and their prevalence increases with age. They are associated with cerebral ischaemia and cognitive dysfunc...

The Use and Misuse of Proton Pump Inhibitors: An Opportunity for Deprescribing.

Dec 17, 2020

Proton pump inhibitors (PPIs) are proven medications of choice for gastroesophageal reflux disease (GERD), acid-related disorders, erosive esophagitis, Barrett esophagus, prevention of gastrointestina...

Number of Patients with Ischemic Stroke did not Decline in a Regional Stroke Unit After the Implementation of Mechanical Thrombectomy.

Dec 14, 2020

Since the implementation of mechanical thrombectomy (MT) in 2015 for patients with ischemic stroke and large-vessel occlusion, the question arose as to whether patients should be primarily admitted to...

Long-term exposure to traffic noise and mortality: A systematic review and meta-analysis of epidemiological evidence between 2000 and 2020.

Dec 14, 2020

We aimed to update the evidence-base of long-term noise exposures from road, rail, and aircraft traffic on both non-accidental and cardiovascular mortality. A systematic review and meta-analysis were ...

Acute neuroinflammation, sickness behavior and working memory in response to acute systemic challenge with LPS following noradrenergic lesion in mice.

Dec 14, 2020

Locus coeruleus (LC)-derived noradrenaline is important in cognition and decreases with age, but the impact of prior noradrenaline deficiency on vulnerability to inflammation-induced acute cognitive d...

L'effet de la transfusion des globules rouges sur l'apport et la consommation d'oxygène au niveau des tissus périphériques chez patients septiques gravement malades.

Dec 14, 2020

The impact of blood transfusion on tissue oxygen delivery (DO) and tissue oxygen consumption (VO) is a subject of current clinical studies. The primary objective of this observational study is to eval...

The Genus Nepeta: Traditional uses, Phytochemicals and Pharmacological Properties.

Dec 14, 2020

Nepeta is a multiregional genus of the "Lamiaceae" (Labiatae or Mint) family. Species of Nepeta are a valuable part of traditional medicine and used extensively, particularly in the Himalayan region o...

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