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Critical Care General

Non-invasive assessment of cerebral microvascular changes for predicting postoperative cerebral hyperperfusion after surgical revascularisation for moyamoya disease: an arterial spin labelling MRI study.

Oct 26, 2020

Cerebral hyperperfusion syndrome (CHPS) can result after anastomotic surgery as the reperfusion is established in chronically ischemic cerebral territories in patients of moyamoya disease (MMD). In th...

Identification of Cytochrome b-245, beta-chain gene mutations, and clinical presentations in Iranian patients with X-linked chronic granulomatous disease.

Oct 26, 2020

X-linked chronic granulomatous disease (X-CGD) is an immunodeficiency disorder caused by defects in the gp91 subunit that leads to life-threatening infections. We aimed to identify CYBB gene mutations...

SLy2-deficiency promotes B-1 cell immunity and triggers enhanced production of IgM and IgG antibodies against pneumococcal vaccine.

Oct 26, 2020

Despite the benefits of existing vaccines, Streptococcus pneumoniae is still responsible for the greatest proportion of respiratory tract infections around the globe, thereby substantially contributin...

Aortic arch types and postoperative outcomes after carotid artery stenting in asymptomatic and symptomatic patients.

Oct 26, 2020

To investigate the influence of the aortic arch type on technical and clinical success of carotid artery stenting (CAS) procedure.Clinical and anatomical data of consecutive patients who underwent CAS...

Social Determinants of Myocardial Infarction Risk and Survival: A Systematic Review.

Oct 26, 2020

Social determinants of health that have been examined in relation to myocardial infarction incidence and survival include socioeconomic status (income, education), neighbourhood disadvantage, immigrat...

Vascular Quality Initiative Risk Score for 30-day Stroke or Death Following TransCarotid Artery Revascularization.

Oct 26, 2020

Transcarotid artery revascularization (TCAR) using a flow-reversal neuroprotection system has gained popularity for the endovascular treatment of carotid artery atherosclerotic disease due to its lowe...

Ankle arthritis - an important signpost in rheumatologic practice.

Oct 26, 2020

Ankle arthritis is a useful clinical signpost to differential diagnosis in rheumatic disease. Biomechanical features and differences in cartilage physiology compared with the knee may confer protectio...

COVID-19 associated coagulopathy in critically ill patients: A hypercoagulable state demonstrated by parameters of haemostasis and clot waveform analysis.

Oct 26, 2020

Patients with COVID-19 are known to be at risk of developing both venous, arterial and microvascular thrombosis, due to an excessive immuno-thrombogenic response to the SARS-CoV-2 infection. Overlappi...

The significance of acute kidney injury in Clostridioides difficile infection.

Oct 26, 2020

Clostridioides difficile infection (CDI) may present as sepsis with acute kidney injury (AKI). Herein, we aimed to evaluate the clinical outcomes of patients with AKI complicating CDI.All consecutive ...

Effects of interval-training exercise on people with persistent post-concussive symptoms less than one year: a pilot study.

Oct 26, 2020

This study is to examine the effects of a 12-session moderate intensity-interval-training program with blood flow restriction (BFR) and body cooling (BC) on people with persistent post-concussive symp...

Traumatic Optic Nerve Injury Elevates Plasma Biomarkers of Traumatic Brain Injury in a Porcine Model.

Oct 26, 2020

A diagnosis of traumatic brain injury (TBI) is typically based upon patient medical history, clinical exam and imaging tests. Elevated plasma levels of glial fibrillary acidic protein (GFAP), ubiquiti...

Cardiac resynchronization therapy in heart failure patients: tough road but clear future.

Oct 26, 2020

Cardiac resynchronization therapy (CRT) based on biventricular pacing (BVP) is an invaluable intervention currently used in heart failure (HF) patients. The therapy involves electromechanical dyssynch...

Dyskalemia: a management problem for students.

Oct 26, 2020

Although dyskalemia is common, its management can be problematic for students and general practitioners, especially when it occurs in patients with heart and renal failure. The basic academic knowledg...

Neuroprotective effects of flavone luteolin in neuroinflammation and neurotrauma.

Oct 26, 2020

Neuroinflammation leads to neurodegeneration, cognitive defects, and neurodegenerative disorders. Neurotrauma/traumatic brain injury (TBI) can cause activation of glial cells, neurons, and neuroimmune...

Social deprivation and one-year survival after stroke: a prospective cohort study.

Oct 26, 2020

Social deprivation may have a deleterious influence on post-stroke outcomes, but available data in the literature are mixed.The aim of this cohort study was to evaluate the impact of social deprivatio...

Brachyury engineers cardiac repair competent stem cells.

Oct 26, 2020

To optimize the regenerative proficiency of stem cells, a cardiopoietic protein-based cocktail consisting of multiple growth factors has been developed and advanced into clinical trials for treatment ...

Radiographic features and poor prognostic factors of interstitial lung disease with nivolumab for non-small cell lung cancer.

Oct 26, 2020

Nivolumab can cause interstitial lung disease (ILD), which may be fatal; however, mortality risk factors have not been identified. This post-marketing study evaluated the poor prognostic factors of IL...

D-Carvone inhibit cerebral ischemia/reperfusion induced inflammatory response TLR4/NLRP3 signaling pathway.

Oct 22, 2020

To explore the present treatment strategies for ischemic stroke lowered by ischemia-reperfusion (I/R) injury, to hypothesize the effect of d-Carvone on cerebral I/R brain injury induced neuroinflammat...

The Problem of Microbial Dark Matter in Neonatal Sepsis.

Oct 22, 2020

Neonatal sepsis (NS) kills 750,000 infants every year. Effectively treating NS requires timely diagnosis and antimicrobial therapy matched to the causative pathogens, but most blood cultures for suspe...

Association of gender, age, and race on renal outcomes and mortality in patients with severe sepsis and septic shock.

Oct 22, 2020

The association of age, gender and race with renal outcomes in patients with severe sepsis and septic shock (SEP) is not completely elucidated. We aimed to shed light on these relationships.We perform...

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