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Critical Care General

3-[(4-chlorophenyl)selanyl]-1-methyl-1H-indole ameliorates long-lasting depression- and anxiogenic-like behaviors and cognitive impairment in post-septic mice: Involvement of neuroimmune and oxidative hallmarks.

Oct 12, 2020

Only in the last decade the long-term consequences of sepsis started to be studied and even less attention has been given to the treatment of psychological symptoms of sepsis survivors. It is estimate...

Septic shock caused by acute appendicitis complicated with abscess formation within mesoappendix: A case report.

Oct 12, 2020

Acute appendicitis is the most common surgical emergency and may present with a wide variety of clinical manifestations. In rare circumstances, appendicitis can cause life-threatening complications e....

[The Role of the Critical Care Pharmacist during the COVID-19 pandemic].

Oct 12, 2020

On January 4 2020, the World Health Organization (WHO) reported the emergence of a cluster of pneumonia cases in Wuhan, China due to a new coronavirus, the SARS-CoV-2. A few weeks later, hospitals had...

Extent of lung involvement over severity of cardiac disease for the prediction of adverse outcome in COVID-19 patients with cardiovascular disease.

Oct 12, 2020

Aim of the present study was to assess if the presence of high cardiovascular risk, left ventricle systolic dysfunction or elevated BNP or Troponin are able to independently predict the outcome of pat...

Association of immune checkpoint inhibitors with respiratory infections: A review.

Oct 12, 2020

Treatment with immune-checkpoint inhibitors (ICIs) has shown efficacy against a variety of cancer types. The use of anti PD-1, anti PD-L1, and anti CTLA-4 antibodies is rapidly expanding. The side eff...

Seasonality of Influenza-Like-Illness and Acute Cardiovascular Events Are Related Regardless of Vaccine Effectiveness.

Oct 12, 2020

Background Influenza has been identified as a trigger for stroke and myocardial infarction (MI) with prior studies demonstrating that influenza vaccination may decrease risk of stroke and MI. Methods ...

Septic pulmonary emboli caused by Tsukamurella inchonensis: A case report.

Oct 12, 2020

The genus Tsukamurella is a fastidious, environmental organism that potentially causes various infections in humans. Due to the morphological and biochemical similarities to others pathogens, such as ...

Pediatric osteoarticular infection: trend in surgically treated patients and association of methicillin-resistant Staphylococcus aureus with requirement of secondary procedures.

Oct 12, 2020

Acute pediatric osteoarticular infection demonstrates variability in both presentation and response to treatment. Many respond to antibiotics ± single operation, while some require multiple surge...

Calpain Activation and Organ Failure in Sepsis: Molecular Insights and Therapeutic Perspectives.

Oct 12, 2020

Sepsis is a severe systemic response to infection; its ensuing organ failure commonly portends an unfavourable prognosis. Despite the fact that sepsis has been studied for decades, the molecular mecha...

The learning effect of the King-Devick test in semi-professional rugby union athletes.

Oct 12, 2020

Abnormalities of eye movement and visual processing are common in traumatic brain injury. The King-Devick test (KDT) has been widely used in the detection and recovery of concussion. Current recommend...

Immuno-suppressive hydrogels enhance allogeneic MSC survival after transplantation in the injured brain.

Oct 12, 2020

Traumatic brain injury (TBI) triggers multiple biochemical and cellular processes that exacerbate brain tissue damage through a secondary injury. Therapies that prevent or limit the evolution of secon...

Evaluating Multiple Domains of Health in High School Athletes With Sport-Related Concussion.

Oct 12, 2020

Concussions are shown to hinder multiple health dimensions, including health-related quality of life (HRQOL), suggesting a need for a whole-person approach to assessment and treatment. Patient-reporte...

sST2 and Diuretic Efficiency in Acute Heart Failure and Concomitant Renal Dysfunction.

Oct 12, 2020

Identifying patients at risk of poor diuretic response in acute heart failure (AHF) is critical to make prompt adjustments in therapy. The objective of this study was to investigate whether the circul...

Plasma Volume Status and its Association with In-Hospital and Post-Discharge Outcomes in Decompensated Heart Failure.

Oct 12, 2020

Prior analyses suggest an association between formula-based plasma volume (PV) estimates and outcomes in heart failure (HF). We assessed the association between estimated PV-status by the Duarte-ePV a...

VENTILATION DISPERSION INDEX AS AN OBJECTIVE EVALUATION TOOL OF EXERCISE OSCILLATORY VENTILATION IN PATIENTS WITH HEART FAILURE.

Oct 12, 2020

Exercise oscillatory ventilation (EOV) is related to worse prognosis in patients with heart failure (HF). However, its determination is subjective and there is no standard measure to identify it. The ...

Acute injection of a DHA triglyceride emulsion after hypoxic-ischemic brain injury in mice increases both DHA and EPA levels in blood and brain.

Oct 12, 2020

We recently reported that acute injection of docosahexaenoic acid (DHA) triglyceride emulsions (tri-DHA) conferred neuroprotection after hypoxic-ischemic (HI) injury in a neonatal mouse stroke model. ...

Associations between short-term exposure to PM and stroke incidence and mortality in China: A case-crossover study and estimation of the burden.

Oct 08, 2020

Stroke and fine particulate matter (PM) are two important public health concerns worldwide. Although numerous studies have reported the associations between PM and stroke, scientific evidence in China...

Covid-19 and kidney injury: Pathophysiology and molecular mechanisms.

Oct 08, 2020

The novel coronavirus (SARS-CoV-2) has turned into a life-threatening pandemic disease (Covid-19). About 5% of patients with Covid-19 have severe symptoms including septic shock, acute respiratory dis...

Novel anti-tubercular and antibacterial based benzosuberone-thiazole moieties: Synthesis, molecular docking analysis, DNA gyrase supercoiling and ATPase activity.

Oct 08, 2020

Herein, molecular hybridization strategy was utilized in the design of new benzosuberone-thiazole derivatives. The structures of the synthesized hybrids were determined on the basis of elemental and s...

SARS-CoV-2 infections in cancer outpatients-Most infected patients are asymptomatic carriers without impact on chemotherapy.

Oct 08, 2020

Oncologic patients are regarded as the population most at risk of developing a severe course of COVID-19 due to the fact that malignant diseases and chemotherapy often weaken the immune system. In the...

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