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Critical Care General

Population pharmacokinetics and model-based dosing optimization of teicoplanin in elderly critically ill patients with pneumonia.

Aug 28, 2023

To evaluate the population pharmacokinetics and pharmacodynamics of teicoplanin in elderly critically ill patients with pneumonia for optimal dosages.Fifteen critically ill patients (9 men) ≥ 60 ...

Extracorporeal membrane oxygenation in immunocompromised patients with acute respiratory failure: A retrospective cohort study.

Aug 28, 2023

The clinical indications of extracorporeal membrane oxygenation (ECMO) in immunosuppressed patients are not clear. This study aimed to analyse the effectiveness of ECMO and to identify the risk factor...

Inflammation-responsive Drug Delivery Nanosystems for Treatment of Bacterial-induced Sepsis.

Aug 28, 2023

Sepsis, a complication of dysregulated host immune systemic response to an infection, is life threatening and causes multiple organ injuries. Sepsis is recognized by WHO as a big contributor to global...

Timing of midstream urine culture before endourological procedure-can we do better?-A comparative study.

Aug 28, 2023

Endourological procedures are the mainstay of treatment for stone disease in the upper urinary system. Infection is a common complication, and urine cultures (UC) are often obtained preoperatively. In...

Statistical properties of cerebral near infrared and intracranial pressure-based cerebrovascular reactivity metrics in moderate and severe neural injury: a machine learning and time-series analysis.

Aug 28, 2023

Cerebrovascular reactivity has been identified as a key contributor to secondary injury following traumatic brain injury (TBI). Prevalent intracranial pressure (ICP) based indices of cerebrovascular ...

Repeated closed-head mild traumatic brain injury-induced inflammation is associated with nociceptive sensitization.

Aug 28, 2023

Individuals who have experienced mild traumatic brain injuries (mTBIs) suffer from several comorbidities, including chronic pain. Despite extensive studies investigating the underlying mechanisms of m...

Long-Term Treatment With Sacubitril/Valsartan in Japanese Patients With Chronic Heart Failure and Reduced Ejection Fraction - Open-Label Extension of the PARALLEL-HF Study.

Aug 28, 2023

The PARALLEL-HF study assessed the efficacy and safety of sacubitril/valsartan vs. enalapril in Japanese patients with chronic heart failure with reduced ejection fraction (HFrEF). This open-label ext...

Effect of norepinephrine on the vascular waterfall and tissue perfusion in vasoplegic hypotensive patients: a prospective, observational, applied physiology study in cardiac surgery.

Aug 21, 2023

Norepinephrine is a commonly used drug for treating vasoplegic acute circulatory failure in ICU. The prediction of norepinephrine macro- and micro-circulatory response is complicated by its uneven rec...

Minimal effective dose of maintenance steroid therapy for relapse of cryptogenic organizing pneumonia.

Aug 21, 2023

Long-term maintenance steroid therapy (MST) is frequently required for repeated relapses of cryptogenic organizing pneumonia (COP); however, the optimal minimal dose has not been clarified. Therefore,...

Haemophilus influenzae infection of a prosthetic knee joint in a patient with rheumatoid arthritis : A case report.

Aug 21, 2023

A 60-year-old female was admitted to internal medicine with a painful left knee after a fall and pneumonia. She had undergone a primary cemented left total knee arthroplasty in 2019 and a right c...

Clinical characteristics of and risk factors for poor outcomes in children with bacterial culture-negative septic arthritis of the hip.

Aug 21, 2023

Septic arthritis of the hip is a serious infection in children. However, blood and joint fluid cultures are often negative, which makes the diagnosis and treatment challenging. We analyzed the clinica...

Morpho-mechanical mapping of human dura mater microstructure.

Aug 21, 2023

The human dura mater is known to impact vastly traumatic brain injury mechanopathology. In spite of this involvement, dura mater is typically neglected in computational and physical human head models....

Selection of a statistical analysis method for the Glasgow Outcome Scale-Extended endpoint for estimating the probability of favorable outcome in future severe TBI clinical trials.

Aug 21, 2023

The Glasgow outcome scale-extended (GOS-E), an ordinal scale measure, is often selected as the endpoint for clinical trials of traumatic brain injury (TBI). Traditionally, GOS-E is analyzed as a fixed...

Impact of human serum albumin level on symptomatic cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage.

Aug 14, 2023

To investigate the impact of human serum albumin (HSA) levels on symptomatic cerebral vasospasm (SCVS) in patients with aneurysmal subarachnoid hemorrhage (aSAH).We retrospectively reviewed the medica...

Successful management of an amputated hand at the distal row level of carpal bones in low-resources country: A case report.

Aug 14, 2023

Hand replantation (HR) surgery is a delicate and complex procedure that requires a multidisciplinary team (MT) and specialized equipment, as well as factors such as ischemia time and injury mechanism ...

Peripherin: A proposed biomarker of traumatic axonal injury triggered by mechanical force.

Aug 14, 2023

Traumatic axonal injury (TAI) is one of the most common pathological features of severe traumatic brain injury (TBI). Our previous study using proteomics suggested that peripherin (PRPH) should be a p...

A single-centre observational study of delayed defaecation in brain-injured patients in an adult intensive care unit.

Aug 14, 2023

The incidence of delayed defaecation is high in enterally fed ventilated patients in intensive care units (ICUs). Those with brain injury may be harmed by increased intracranial pressure if delayed de...

Angiopoietin-2 is associated with capillary leak and predicts complications after cardiac surgery.

Aug 14, 2023

Patients undergoing cardiac surgery are prone to numerous complications. Increased vascular permeability may be associated with morbidity and mortality due to hemodynamic instability, fluid overload, ...

IMPACT OF extending CRITERIA for HOME CARE MANAGEMENT in PRETERM PRELABOR RUPTURE OF MEMBRANES.

Aug 07, 2023

Preterm prelabor rupture of membranes (PPROM) is a frequent obstetrical condition with risks of maternal and neonatal morbidity and mortality. Home hospitalization (HH) management is an alternative to...

Managing tandem breastfeeding during acute hospitalization: A case study.

Aug 07, 2023

This case study presents a mother who continued tandem breastfeeding throughout the acute admission of her critically ill newborn. Her younger child, the subject of this case report was admitted to ou...

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