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Critical Care General

Preterm children's long-term academic performance after adaptive computerized training: an efficacy and process analysis of a randomized controlled trial.

Sep 14, 2020

Adaptive computerized interventions may help improve preterm children's academic success, but randomized trials are rare. We tested whether a math training (XtraMath®) versus an active control condit...

Theophylline dosing and pharmacokinetics for renal protection in neonates with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia.

Sep 14, 2020

Theophylline, a non-selective adenosine receptor antagonist, improves renal perfusion in the setting of hypoxia-ischemia and may offer therapeutic benefit in neonates with hypoxic-ischemic encephalopa...

Home parenteral nutrition in neuroendocrine tumour intestinal failure: improved quality of life and longevity.

Sep 14, 2020

Neuroendocrine tumours (NETs) are neoplastic yet behave differently to typical cancers. Despite often being slow growing, they can lead to significant gastrointestinal complications including intestin...

Using National Early Warning Score (NEWS) 2 to help manage medical emergencies in the dental practice.

Sep 14, 2020

If a medical emergency occurs in the dental practice, members of the dental team must be able to respond promptly, effectively and safely. Fundamental to this response is knowing when it is necessary ...

S100A9 Upregulation Contributes to Learning and Memory Impairments by Promoting Microglia M1 Polarization in Sepsis Survivor Mice.

Sep 14, 2020

Sepsis-associated encephalopathy (SAE) is a clinical syndrome of brain dysfunction secondary to sepsis, which is characterized by long-term neurocognitive deficits such as memory, attention, and execu...

Trajectories of vital signs in patients with COVID-19.

Sep 14, 2020

The global health pandemic of coronavirus disease 2019 (COVID-19) is placing a huge strain on UK hospitals. Early studies suggest that patients can deteriorate quickly after admission to hospital. The...

Lipid laden macrophages and electronic cigarettes in healthy adults.

Sep 14, 2020

An outbreak of E-cigarette or Vaping Product Use-Associated Lung Injury (EVALI) with significant morbidity and mortality was reported in 2019. While most patients with EVALI report vaping tetrahydroca...

Can CT performed in the early disease phase predict outcome of patients with COVID 19 pneumonia? Analysis of a cohort of 64 patients from Germany.

Sep 14, 2020

The aim of this study was to investigate if CT performed in the early disease phase can predict the course of COVID-19 pneumonia in a German cohort.All patients with RT-PCR proven COVID-19 pneumonia a...

Elevated levels of autoantibodies against DNAJC2 in sera of patients with atherosclerotic diseases.

Sep 14, 2020

Serum antibody markers have been increasingly identified not only for cancer and autoimmune diseases but also for atherosclerosis-related diseases such as acute ischemic stroke (AIS), acute myocardial...

Adherence to study drug in a stroke prevention trial"?>.

Sep 14, 2020

Standards for reporting and analyzing adherence to medical therapy have recently improved due to international consensus efforts. If applied to clinical trial research in patients with stroke, these i...

Profile and correlates of injecting-related injuries and diseases among people who inject drugs in Australia.

Sep 14, 2020

People who inject drugs (PWID) commonly experience harms related to their injecting, many of which are consequences of modifiable drug use practices. There is currently a gap in our understanding of h...

Good Functional Outcomes and Low Infection Rates in Total Hip Arthroplasty in HIV-Positive Patients, Provided There Is Strict Compliance With Highly Active Antiretroviral Therapy.

Sep 14, 2020


Patients with HIV are more likely to require a total hip arthroplasty (THA) because of an increase in life expectancy and complications with HIV. The purpose of this study is to describe the mid-te...

Long-lasting blood-brain barrier dysfunction and neuroinflammation after traumatic brain injury.

Sep 14, 2020

Traumatic brain injury (TBI) causes 10-20% of acquired epilepsy, which typically develops within 2 years post-injury with poorly understood mechanisms. We investigated the location, severity, evolut...

Factors associated with concussion symptom knowledge and attitudes towards concussion care-seeking in a national survey of parents of middle school children in the U.S.

Sep 14, 2020

Developing appropriate concussion prevention and management paradigms in middle school (MS) settings requires understanding parents' general levels of concussion-related knowledge and attitudes. This ...

Expression Profiles of Long Non-coding RNA and Messenger RNA in Human Traumatic Brain Injury.

Sep 14, 2020

Long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) play an important role in central nervous diseases; however, the exact expression and co-expressed profiles in human traumatic brain injury (T...

Lopinavir-Ritonavir in SARS-CoV-2 Infection and Drug-Drug Interactions with Cardioactive Medications.

Sep 14, 2020

Lopinavir-ritonavir combination is being used for the treatment of SARS-CoV-2 infection. A low dose of ritonavir is added to other protease inhibitors to take advantage of potent inhibition of cytochr...

Apolipoprotein Proteomic Profiling for the Prediction of Cardiovascular Death in Patients with Heart Failure.

Sep 14, 2020

Risk stratification in chronic systolic heart failure (HF) is critical to identify the patients who may benefit from advanced therapies. We aimed identifying new biomarkers to improve prognosis evalua...

A rare hepatic mass in an Italian resident.

Sep 14, 2020

Amebiasis is a rare condition in developed countries but epidemiologically growing. Clinical manifestation may range from asymptomatic to invasive disease, amoebic liver abscess being the most common ...

Exercise training reveals micro-RNAs associated with improved cardiac function and electrophysiology in rats with heart failure after myocardial infarction.

Sep 14, 2020

Endurance training improves aerobic fitness and cardiac function in individuals with heart failure. However, the underlying mechanisms are not well characterized. Exercise training could therefore act...

One-stage closure of large bronchopleural fistula with pedicled latissimus dorsi muscle flap after preemptive antibiotics: A case report.

Sep 10, 2020

Bronchopleural fistula (BPF) after lung cancer surgery is a life-threatening complication and often needs two-stage closure after fenestration. Although one-stage closure of BPF is challenging, it wou...

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