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Critical Care General

Mechanosensitive traction force generation is regulated by the neutrophil activation state.

Jul 10, 2023

The generation of traction forces by neutrophils regulates many crucial effector functions responsible for host defense, such as attachment, spreading, migration, phagocytosis, and NETosis. The activa...

Continuous renal replacement therapy with the adsorptive oXiris filter may be associated with the lower 28-day mortality in sepsis: a systematic review and meta-analysis.

Jul 10, 2023

The oXiris is a novel filter for continuous renal replacement therapy (CRRT) featuring an adsorption coating to adsorb endotoxins and remove inflammatory mediators. Given that no consensus has been re...

Propensity-matched analysis of robotic versus sternotomy approaches for mitral valve replacement.

Jul 10, 2023

To compare early and medium-term outcomes between robotic and sternotomy approaches for mitral valve replacement (MVR). Clinical data of 1393 cases who underwent MVR between January 2014 and January 2...

Pathogen spectrum of community acquired pneumonia in people living with HIV (PLWH) in the German CAPNETZ-Cohort.

Jul 10, 2023

The objective of this study was to identify the pathogen spectrum of community acquired pneumonia in people living with HIV (PLWH), and to compare it with a matched HIV negative group in order to reas...

Immunotherapies for the prevention and treatment of Staphylococcus aureus infections: updates and challenges.

Jul 10, 2023

Staphylococcus aureus is the leading cause of hospital-acquired infections and can cause a wide range of diseases from mild skin infections to invasive diseases including deep surgical site infections...

Rosavin inhibits neutrophil extracellular traps formation to ameliorate sepsis-induced lung injury by regulating the MAPK pathway.

Jul 10, 2023

Sepsis is a systemic organ dysfunction caused by infection, and the most affected organ is the lungs. Rosavin, a traditional Tibetan medicine, exerts an impressive anti--inflammatory effect. However, ...

Traumatic brain injury-induced fear generalization in mice involves hippocampal memory trace dysfunction and is alleviated by (R,S)-ketamine.

Jul 10, 2023

Traumatic brain injury (TBI) is a debilitating neurological disorder caused by an impact to the head by an outside force. TBI results in persistent cognitive impairments, including fear generalization...

Lower systemic nitric oxide bioactivity, cerebral hypoperfusion and accelerated cognitive decline in formerly concussed retired rugby union players.

Jul 10, 2023

What is the central question of this study? What are the molecular, cerebrovascular and cognitive biomarkers of retired rugby union players with concussion history? What is the main finding and its im...

The place of new antibiotics for Gram-negative bacterial infections in intensive care: report of a consensus conference.

Jul 10, 2023

New beta-lactams, associated or not with beta-lactamase inhibitors (NBs/BIs), can respond to the spread of carbapenemase-producing enterobacteriales and nonfermenting carbapenem-resistant bacteria. Th...

Pericyte-Mediated Molecular Mechanisms Underlying Tissue Repair and Functional Recovery after Ischemic Stroke.

Jul 03, 2023

There are still many patients suffering from ischemic stroke and related disabilities worldwide. To develop a treatment that promotes functional recovery after acute ischemic stroke, we need to elucid...

Neutrophil elastase in dexmedetomidine alleviating sepsis-related renal injury in rats.

Jul 03, 2023

This research was to investigate the mechanism of neutrophil elastase (NE) in dexmedetomidine (DEX) alleviates sepsis-related renal injury in rats.Sixty healthy male SD rats aged 6-7 weeks were rando...

Identification of module genes and functional pathway analysis in septic shock subtypes by integrated bioinformatics analysis.

Jul 03, 2023

The present study aimed to identify the module genes and key gene functions and biological pathways of septic shock (SS) through integrated bioinformatics analysis.In the study, we performed batch cor...

Effects of inhalation of multi-walled carbon nanotube (MWCNT) on respiratory syncytial virus (RSV) infection in mice.

Jul 03, 2023

Multi-walled carbon nanotubes (MWCNTs), a kind of nanomaterial, are widely used in battery electrodes and composite materials, but the adverse effects associated with their accumulation in the living ...

Help is on the way: critical roles of CD4 T cells in infection and vaccination.

Jul 03, 2023

The July 2023 issue contains a Special Feature about CD4 T cells in infection and vaccination. CD4 T helper cells are composed of many specialized subsets that play critical roles in immune memory. Th...

Gender and racial differences in first and senior authorship of high-impact critical care randomized controlled trial studies from 2000 to 2022.

Jul 03, 2023

Females and ethnic minorities are underrepresented in the first and senior authorships positions of academic publications. This stems from various structural and systemic inequalities and discriminati...

A new assessment method for right ventricular diastolic function using right heart catheterization by pressure-volume loop.

Jul 03, 2023

Diastolic stiffness coefficient (β) and end-diastolic elastance (Eed) are ventricular-specific diastolic parameters. However, the diastolic function of right ventricle had not been investigated suffi...

Schisandrin B Protects against Ischemic Brain Damage by Regulating PI3K/AKT Signaling in Rats.

Jun 26, 2023

To explore the effect and mechanism of schisandrin B (Sch B) in the treatment of cerebral ischemia in rats.The cerebral ischemia models were induced by middle cerebral artery occlusion (MCAO) and repe...

White Matter Hyperintensity as a Vascular Contribution to the AT(N) Framework.

Jun 26, 2023

The AT(N) framework enables the classification of an individual within the biological Alzheimer's disease (AD) continuum by pairing the cognitive stage with the biomarker status of amyloid-beta (Aβ, ...

Clearance of intracellular bacterial infections by hyaluronic acid-based ROS responsive drug delivery micelles.

Jun 26, 2023

Pathogenic bacteria residing inside cells could cause disruption of cellular metabolic balance. Therefore, basing on high oxidative stress response of the intracellular bacteria infected micro-environ...

[Diagnosis and treatment of 26 cases of adenovirus infection after allogeneic hematopoietic stem cell transplantation].

Jun 26, 2023

To analyze the clinical characteristics and prognosis of adenovirus infection after allogeneic hematopoietic stem cell transplantation. A total of 26 patients with adenovirus infection admitted to t...

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