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Critical Care General

Digoxin Initiation and Outcomes in Patients with Heart Failure (HFrEF and HFpEF) and Atrial Fibrillation.

Jul 02, 2020

Digoxin reduces the risk of heart failure hospitalization but has no effect on mortality in patients with heart failure without atrial fibrillation in the randomized controlled trial setting. Observat...

Exercise Training Effects on the Relationship of Physical Function and Health-Related Quality of Life Among Older Heart Failure Patients With Preserved Ejection Fraction.

Jul 02, 2020

Although exercise training (ET) has been shown to improve both physical function and health-related quality of life (HRQOL) in older patients with heart failure and preserved ejection fraction (HFpEF)...

Phthalide derivative CD21 ameliorates ischemic brain injury in a mouse model of global cerebral ischemia: involvement of inhibition of NLRP3.

Jun 29, 2020

The activation of NLRP3 inflammasome is closely related to ischemic brain injury and inhibition of NLRP3 inflammasome activation may be a new therapeutic strategy for ischemic stroke. Our previous stu...

Probiotics Reduce Mortality and Morbidity in Preterm, Low Birth Weight Infants: a Systematic Review and Network Meta-analysis of Randomized Trials.

Jun 29, 2020

We aimed to compare the effectiveness of single- vs multiple-strain probiotics in a network meta-analysis of randomized trials.We searched MEDLINE, EMBASE, Science Citation Index Expanded, CINAHL, Sco...

Shenfu injection prevents sepsis-induced myocardial injury by inhibiting mitochondrial apoptosis.

Jun 29, 2020

Shenfu injection (SFI) is a well-known Chinese herbal medicine widely used in the treatment of septic shock in China.The aims of this study are to investigate the protective effects of SFI on sepsis-i...

Elevated body-mass index is associated with an increased risk of infectious disease admissions and mortality: a mendelian randomization study.

Jun 29, 2020

The effect of body-mass index (BMI) on the risk of infectious diseases admissions and mortality is unclear and is difficult to study given risks of confounding variables.We used genome-wide associatio...

Coccidioidal meningitis in non-AIDS patients. A case series at a Mexican neurological referral center.

Jun 29, 2020

Coccidioidal meningitis is a life-threatening condition and a diagnostic challenge in cases of chronic meningitis. It is associated to severe complications, like basal arachnoiditis, hydrocephalus, an...

Favorable COVID-19 course despite significant comorbidities in a ruxolitinib-treated patient with primary myelofibrosis.

Jun 29, 2020

COVID-19 carries a high risk of severe disease course, particularly in patients with comorbidities. Therapy of severe COVID-19 infection has relied on supportive intensive care measures. More specific...

Frequency of Right Ventricular Infarction in Inferior Wall Myocardial Infarction.

Jun 29, 2020

Background Ischemic heart disease, particularly inferior wall myocardial infarction (IWMI), is a significant issue in cardiac health. It can further add up to the morbidity and mortality when it is as...

Potential Indirect Effects of the COVID-19 Pandemic on Use of Emergency Departments for Acute Life-Threatening Conditions - United States, January-May 2020.

Jun 29, 2020

On March 13, 2020, the United States declared a national emergency in response to the coronavirus disease 2019 (COVID-19) pandemic. Subsequently, states enacted stay-at-home orders to slow the spread ...

[Study of the influence of etoxidol on expression of follistatin-like protein-1 (FSTL-1) in myocardium after experimental infarction in rats].

Jun 29, 2020

In heart attack, FSTL-1 is actively secreted by cardiomyocytes, accelerates growth of heart myofibrils and stimulates of vascular endothelial growth factor expression. The aim of this work was to inve...

Arthrotomy debridement of arthrostic septic arthritis of the knee is more effective than arthroscopic debridement and delays the need for prosthesis despite progression.

Jun 29, 2020

40%-50% of this septic arthritis occurs in the knee, despite rapid medical surgical treatment, 24%-50% will have a poor clinical outcome. It is not clear which debridement technique, by arthrotomy or ...

Could there be a link between oral hygiene and the severity of SARS-CoV-2 infections?

Jun 29, 2020

On 30 January 2020, the World Health Organisation identified COVID-19, caused by the virus SARS-CoV-2, to be a global emergency. The risk factors already identified for developing complications from a...

Epidemiology and burden of sepsis acquired in hospitals and intensive care units: a systematic review and meta-analysis.

Jun 29, 2020

Sepsis is recognized as a global public health problem, but the proportion due to hospital-acquired infections remains unclear. We aimed to summarize the epidemiological evidence related to the burden...

Zebrafish model of posttraumatic epilepsy.

Jun 29, 2020

Posttraumatic epilepsy (PTE) is defined as recurrent and unprovoked seizures occurring >1 week after traumatic brain injury (TBI). Animal studies of PTE are lengthy and expensive. In this study, w...

An active avoidance behavioral paradigm for use in a mild closed head model of traumatic brain injury in mice.

Jun 29, 2020

A mild traumatic brain injury (TBI) occurs to millions of people each year. Translational approaches to understanding the pathogenesis of neurological diseases and the testing of the effectiveness of ...

Comparison between Midline and Lateral Fluid Percussion Injury in Mice Reveals Prolonged but Divergent Cortical Neuroinflammation.

Jun 29, 2020

Animal models are critical for determining the mechanisms mediating traumatic brain injury-induced (TBI) neuropathology. Fluid percussion injury (FPI) is a widely used model of brain injury typically ...

Cardiac Sarcoidosis.

Jun 29, 2020

Approximately 5% of patients with sarcoidosis will have cardiac involvement presenting with one or more of ventricular arrhythmias, conduction abnormalities, and heart failure. It is estimated that a...

Cardiac Surgery 2019 Reviewed.

Jun 29, 2020

For the year 2019, almost 25,000 published references can be found in PubMed when entering the search term "cardiac surgery." We used the Preferred Reporting Items for Systematic Reviews and Meta-Anal...

Time trends and patient selection in the use of continuous ECG for detecting atrial fibrillation after stroke: a nationwide cohort study.

Jun 29, 2020

Clinical use of continuous electrocardiogram (cECG) for detecting atrial fibrillation (AF) after stroke is unclear. In a Danish nationwide cohort we described post-stroke time trends in outpatient cEC...

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