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Critical Care General

Diagnosis and Surgical Outcomes of Patients with Anomalous Left Coronary Artery from the Pulmonary Artery: A Single Taiwanese Medical Center Experience.

May 05, 2020

Anomalous left coronary artery from the pulmonary artery (ALCAPA), a very rare congenital cardiac anomaly, is associated with a high mortality rate among infants who are not diagnosed or treated in a ...

Effects of Yixintai Pills on Myocardial Cell Apoptosis in Rats With Adriamycin-Induced Heart Failure.

May 05, 2020

To study the effects of Yixintai pills on myocardial cell apoptosis in rats with adriamycin (ADR)-induced heart failure (HF) and the mechanism of action.Sixty healthy male Wistar rats randomly were di...

Abnormalities in Sodium Current and Calcium Homeostasis as Drivers of Arrhythmogenesis in Hypertrophic Cardiomyopathy.

May 05, 2020

Hypertrophic cardiomyopathy (HCM) is a common inherited monogenic disease with a prevalence of 1/500 in the general population, representing an important cause of arrhythmic sudden cardiac death (SCD)...

Human induced pluripotent stem cells for modelling metabolic perturbations and impaired bioenergetics underlying cardiomyopathies.

May 05, 2020

Normal cardiac contractile and relaxation function are critically dependent on a continuous energy supply. Accordingly, metabolic perturbations and impaired mitochondrial bioenergetics with subsequent...

Growth differentiation factor-11 supplementation improves survival and promotes recovery after ischemic stroke in aged mice.

May 05, 2020

Growth differentiation factor (GDF) 11 levels decline with aging. The age-related loss of GDF 11 has been implicated in the pathogenesis of a variety of age-related diseases. GDF11 supplementation rev...

Characterization of a porcine model of atrial arrhythmogenicity in the context of ischaemic heart failure.

May 05, 2020

Atrial fibrillation (AF) is a major healthcare challenge contributing to high morbidity and mortality. Treatment options are still limited, mainly due to insufficient understanding of the underlying p...

The value of myocardial perfusion imaging in screening coronary artery disease before kidney transplantation.

May 05, 2020

The value of myocardial single-photon emission computed tomography (SPECT) in pre-transplant evaluation of kidney transplant recipients is controversial. We assessed whether myocardial SPECT predicts ...

Mitochondrial transplantation ameliorates ischemia/reperfusion-induced kidney injury in rat.

May 01, 2020

No real therapeutic modality is currently available for Acute kidney injury (AKI) and if any, they are mainly supportive in nature. Therefore, developing a new therapeutic strategy is crucial. Mitocho...

No way out: Causes of duodenal and gastric outlet obstruction.

May 01, 2020

Upper gastrointestinal obstruction (UGIO), obstruction occurring at the level of the stomach or duodenum, represents only about 5% of bowel obstructions. As with other bowel obstructions, timely diagn...

Association of Sepsis Diagnosis at Daytime and on Weekdays with Compliance to the 3-Hour Sepsis Treatment Bundles: A Multicenter Cohort Study.

May 01, 2020

Compliance with sepsis bundles is associated with better outcomes, but information to support structural actions that might improve compliance is scarce. Few studies have evaluated bundle compliance i...

Fluid Response Evaluation in Sepsis Hypotension and Shock: A Randomized Clinical Trial.

May 01, 2020

Fluid and vasopressor management in septic shock remains controversial. In this randomized controlled trial, we evaluated the efficacy of dynamic measures (stroke volume change during passive leg rais...

Sepsis survivor mice exhibit a behavioral endocrine syndrome with ventral hippocampal dysfunction.

May 01, 2020

Severe acute stressors are known to trigger mood disorders in humans. Sepsis represents one such stressor, and survivors often suffer long term from psychiatric morbidity. We hypothesized that sepsis ...

Soluble Interleukin-2 Receptor (sIL-2r) Level is a Limited Test for the Diagnosis of Adult Secondary Hemophagocytic Lymphohistiocytosis (HLH).

May 01, 2020

Soluble interleukin-2 receptor (sIL-2r) level is used as a diagnostic tool in hemophagocytic lymphohistiocytosis (HLH). However, evidence supporting its use among adults is inadequate.We conducted a r...

Risk factors for predicting mortality in elderly patients with COVID-19: a review of clinical data in China.

May 01, 2020

While elderly patients are at high risk of fatality, research concerning COVID-19 has largely been done on clarifying the clinical features. As such, the present work aims to identify risk factors for...

Murine typhus. How does it affect us in the 21st century? The epidemiology of inpatients in Spain (1997-2015).

May 01, 2020

The aim of this study was to analyse the epidemiological impact of murine typhus in patients who required hospitalization in the National Health System (SNS) in Spain between 1997 and 2015.Murine typh...

Serum albumin-mediated strategy for the effective targeting of SARS-CoV-2.

May 01, 2020

Novel coronavirus (NCoV-19), also known as SARS CoV-2, is a pathogen causing an emerging infection that rapidly increases in incidence and geographic range, is associated with the ever-increasing morb...

Containing COVID-19 among 627,386 Persons Contacting with Diamond Princess Cruise Ship Passengers Disembarked in Taiwan: Big Data Analytics.

May 01, 2020

Low infection and case-fatality rate has been so far observed in Taiwan. One of major success is attributed to making a better use of big data analytics in efficient contacting tracing and management ...

Incident Comorbidities, Aging and the Risk of Stroke in 608,108 Patients with Atrial Fibrillation: A Nationwide Analysis.

May 01, 2020

We hypothesized that the change in stroke risk profile between baseline and follow-up may be a better predictor of ischemic stroke than the baseline stroke risk determination using the CHADS-VASc scor...

Comparison of longitudinal change in sST2 vs BNP to predict major adverse cardiovascular events in asymptomatic patients in the community.

May 01, 2020

Biomarker-based preventative and monitoring strategies are increasingly used for risk stratification in cardiovascular (CV) disease. The aim of this study was to investigate the utility of longitudina...

Prevalence and Associated Risk Factors of Sepsis among Neonates Admitted into Neonatal Intensive Care Units of Public Hospitals in Dhaka.

May 01, 2020

To determine the prevalence and associated risk factors of sepsis among neonates admitted into neonatal intensive care units (NICU) of public hospitals in Dhaka.This was a cross-sectional study conduc...

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