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Critical Care General

Deficiency of platelet adhesion molecule CD226 causes megakaryocyte development and platelet hyperactivity.

Apr 06, 2020

This study used constitutive CD226 gene knockout (KO) mice as a model to investigate the functions and mechanisms of CD226 in megakaryocyte (MK) maturation and platelet activation. Although CD226 defi...

Dual peptide-dendrimer conjugate inhibits acetylation of transforming growth factor β-induced protein and improves survival in sepsis.

Apr 06, 2020

Sepsis is a potentially fatal complication of infections and there are currently no effective therapeutic options for severe sepsis. In this study, we revealed the secretion mechanism of transforming ...

Therapeutic tactics in the deep forms of rectal abscesses complicated by fournie gangrene.

Apr 06, 2020

The aim: To conduct an analysis of the complex treatment of severe forms of rectal abscesses complicated by NF.Materials and methods: The results of treatment in 471 patients with deep forms of RA was...

3D-quantitative structure-activity relationship and antiviral effects of curcumin derivatives as potent inhibitors of influenza H1N1 neuraminidase.

Apr 06, 2020

Curcumin derivatives have been shown to inhibit replication of human influenza A viruses (IAVs). However, it is not clear whether curcumin and its derivatives can inhibit neuraminidase (NA) of influen...

Autosomal Dominant Hyper IgE Syndrome from a single center in Chongqing, China (2009-2018).

Apr 06, 2020

Autosomal dominant hyper IgE syndrome (AD-HIES) caused by STAT3 gene mutation is a rare primary immunodeficiency disease. To better understand the disease, we described the clinical characteristics of...

A fatal pediatric case infected with reassortant avian influenza A(H5N6) virus in Eastern China.

Apr 06, 2020

Avian influenza A(H5N6) keeps evolving, causing outbreaks in birds and sporadic infections in human. Here we report a fatal pediatric infection caused by a novel reassortant H5N6 virus. The patient wa...

Relationship between Non-Alcoholic Fatty Liver Disease and Cardiovascular Disease in Persons with HIV.

Apr 06, 2020

Non-alcoholic fatty liver disease (NAFLD) and human immunodeficiency virus (HIV) are independently associated with cardiovascular disease (CVD). However, the factors associated with NAFLD in persons l...

Effect of concomitant antiplatelet agents on clinical outcomes in the edoxaban vs warfarin in subjects undergoing cardioversion of atrial fibrillation (ENSURE-AF) randomized trial.

Apr 06, 2020

In ENSURE-AF (NCT02072434), the oral Factor Xa inhibitor edoxaban showed similar efficacy and safety vs enoxaparin-warfarin in patients undergoing electrical cardioversion of nonvalvular atrial fibril...

Ischemic and Bleeding Events Among Patients With Acute Coronary Syndrome Associated With Low-Dose Prasugrel vs Standard-Dose Clopidogrel Treatment.

Apr 06, 2020

Prasugrel was approved at a lower dose in 2014 in Japan than in the West because East Asian patients are considered more susceptible to bleeding than Western patients. However, real-world outcomes wit...

Extracranial-intracranial bypass surgery for occlusive atherosclerotic disease of the anterior cerebral circulation: protocol for a systematic review and meta-analysis.

Apr 06, 2020

Occlusive atherosclerotic disease of the anterior cerebral circulation is one of the most common causes of anterior circulation ischemia and stroke. Treatment options include medical therapies (includ...

A protocol for a systematic review and meta-analysis of the diagnostic accuracy of mid-regional pro-adrenomedullin in predicting invasive bacterial infection in children.

Apr 06, 2020

The early recognition of invasive bacterial infections (IBI) in children can be difficult. Clinically it is often challenging to differentiate between the early stages of an IBI and a benign self-limi...

Real life experience with Ceftobiprole in a tertiary care hospital.

Apr 06, 2020

Ceftobiprole is a new therapeutic option for bacterial pneumonia, with activity against most antimicrobial resistant gram-positive cocci, including methicillin-resistant Staphylococcus aureus. Data on...

Are Patients With a History of Septic Arthritis Undergoing Total Knee Arthroplasty at Higher Risk for Revision Surgery? A Single-Center Study.

Apr 06, 2020

The decision to perform a total knee arthroplasty (TKA) on a previously infected knee is made complicated by the higher risk for both a periprosthetic joint infection (PJI) and early failure. There is...

Isolated septic facet joints: an underdiagnosed distinct clinical entity.

Apr 06, 2020

We review a series of isolated septic facet joints (ISFJ) that present as a distinct clinical entity compared with spondylodiscitis. We aim to raise awareness that septic facet joints are not a rare e...

Serious Infections in People with Gout in the United States: A National Study of Incidence, Time-trends and Outcomes.

Apr 06, 2020

To study the epidemiology of hospitalized serious infections in people with gout.We identified people with gout hospitalized with a primary diagnosis of pneumonia, sepsis/bacteremia, urinary tract inf...

[Analysis of the frequency of polytraumatized patients in motorcycle accidents in the pediatric publication attended in the Pediatric Hospital of Sinaloa between the years 2015 and 2017].

Apr 06, 2020

Determine the frequency of polytraumatized pediatric patients involved in motorcycle accidents treated at the Pediatric Hospital of Sinaloa between 2015 and 2017, as well as to determine the frequency...

DPP-4 inhibitor reduces striatal microglial deramification after sensorimotor cortex injury induced by external force impact.

Apr 06, 2020

Dipeptidyl peptidase-4 inhibitors (or gliptins), a class of antidiabetic drugs, have recently been shown to have protective actions in the central nervous system. Their cellular and molecular mechanis...

Assessment of Panfacial Fractures in the Pediatric Population.

Apr 06, 2020

Management of panfacial fractures is critical and often difficult in adults; however, there is little to no literature regarding these fractures in the pediatric population. In this study, we present ...

Alternative substrate metabolism depends on cerebral metabolic state following traumatic brain injury.

Apr 06, 2020

Decreases in energy metabolism following traumatic brain injury (TBI) are attributed to impairment of glycolytic flux and oxidative phosphorylation. Glucose utilization post-TBI is decreased while adm...

The potential of head acceleration measurement to augment current best practice in concussion screening in professional Australian football players.

Apr 06, 2020

To explore the potential utility of head acceleration event (HAE) measurements to augment identification of players for further concussion screening in non-helmeted contact sport.Prospective observati...

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