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Critical Care General

The impact of nephrostomy drainage prior to mini-percutaneous nephrolithotomy in patients with ESBL-positive Escherichia coli.

Mar 23, 2020

Extended-spectrum β-lactamase-producing Escherichia coli (ESBL-EC) is one of the most frightening multidrug-resistant bacteria that usually causes sepsis. Herein we explored the benefits of nephrosto...

A Journey Upstream: Fluctuating Platelet-Specific Genes in Cell Free Plasma as Proof-of-Concept for Using RNA Sequencing to Improve Understanding of Post-Injury Platelet Biology.

Mar 23, 2020

The mechanisms of aberrant circulating platelet behavior following injury remain unclear. Platelets retain megakaryocyte immature ribonucleic acid (RNA) splicing and protein synthesis machinery to alt...

Repurposed molecules for antiepileptogenesis: Missing an opportunity to prevent epilepsy?

Mar 23, 2020

Prevention of epilepsy is a great unmet need. Acute central nervous system (CNS) insults such as traumatic brain injury (TBI), cerebrovascular accidents (CVA), and CNS infections account for 15%-20% o...

Polyplex transfection from intracerebroventricular delivery is not significantly affected by traumatic brain injury.

Mar 23, 2020

Traumatic brain injury (TBI) is largely non-preventable and often kills or permanently disables its victims. Because current treatments for TBI merely ameliorate secondary effects of the initial injur...

Traumatic brain injury mortality among U.S. children and adolescents ages 0-19 years, 1999-2017.

Mar 23, 2020

To examine recent traumatic brain injury (TBI) mortality changes among Americans aged 0-19 years by sex, age, urbanicity, state, and intent/causes of injury.TBI mortality per 100,000 population and ...

Aqueductal Compression By Dilated Virchow-Robin Spaces In The Mesencephalic-Pontine Region Presenting With Symptoms Mimicking Normal Pressure Hydrocephalus: A Case Report And Review Of Literature.

Mar 23, 2020

Dilatation of Virchow-Robin spaces (dVRS) have been described in the development of hydrocephalic syndromes. We report an unusual case of a Type III dVRS presenting as a mimic of normal pressure hydro...

Cannabinol in the spotlight: Toxicometabolomic study and behavioral analysis of zebrafish embryos exposed to the unknown cannabinoid.

Mar 23, 2020

Cannabinol (CBN) is a degradation product of the cannabis metabolite Δ9-tetrahydrocannabinol. The CBN concentration in cannabis leaves ranges between 0.1 and 1.6% (w/w of dry weight); it increases as...

Intracranial hemorrhage type and same-admission mortality in patients with left ventricular assist devices.

Mar 23, 2020

Left ventricular assist devices (LVAD) provide mechanical circulatory support for patients with advanced heart failure. Intracranial hemorrhage in this population represent a significant management ch...

Natriuretic peptides for heart failure screening in nursing homes: a systematic review.

Mar 23, 2020

The high burden of heart failure in nursing-home populations is due to advanced age and comorbidities. Heart failure is often undiagnosed or misdiagnosed in this population and therefore remains untre...

Temporal changes in clinical and radiographic variables in dogs with preclinical myxomatous mitral valve disease: The EPIC study.

Mar 23, 2020

The Evaluation of pimobendan in dogs with cardiomegaly caused by preclinical myxomatous mitral valve disease (EPIC) study monitored dogs with myxomatous mitral valve disease (MMVD) as they developed c...

Systematic DOACs oral anticoagulation in patients with atrial fibrillation and chronic kidney disease: the nephrologist's perspective.

Mar 23, 2020

Atrial fibrillation (AF) is highly prevalent among patients with chronic kidney disease (CKD), and also associated with unfavorable outcome. Anticoagulant therapy is the mainstep of management in such...

Atrial fibrillation for internists: current practice.

Mar 23, 2020

Atrial fibrillation (AF) has become a global epidemic and puts affected patients at high risk of adverse events. In this review we summarise the current evidence on risk factors and complications of A...

The Utility of Plasma Vascular Biomarkers in Systemic Sclerosis: A Prospective Longitudinal Analysis.

Mar 23, 2020

Pulmonary hypertension (PH) and ischemic digital lesions (DL) are two scleroderma vascular outcomes that in cross-sectional studies are associated with abnormalities in biomarkers of angiogenesis. The...

Migraine Headache and Risk of Dementia in the Atherosclerosis Risk in Communities Neurocognitive Study.

Mar 23, 2020

We aimed to assess the association between migraine headache and incident dementia.Migraine is a risk factor for white matter hyperintensities and ischemic stroke, which are both associated with incre...

Statement Addresses Concerns About Heart Meds and COVID-19

Mar 22, 2020

Patients advised to continue ACE inhibitors/ARBs after researcher posits risk for severe COVID-19 infection FRIDAY, March 20, 2020 (HealthDay News) -- Patients already prescribed angiotensin-conv...

Automated Evaluation of Parapapillary Choroidal Microvasculature in Ischemic Optic Neuropathy and Open Angle Glaucoma.

Mar 20, 2020

To determine whether parapapillary choroidal microvasculature (PPCMv) density as measured by optical coherence tomography angiography differs between nonarteritic anterior ischemic optic neuropathy (N...

Gut microbiota and pro/prebiotics in Alzheimer's disease.

Mar 20, 2020

Alzheimer's disease is characterized by the accumulation of amyloid and dysfunctional tau protein in the brain along with the final development of dementia. Accumulation of amyloid in the brain was ob...

A Quality Improvement Project Focused on Improving First Dose Antibiotic Timeliness for Pediatric Intensive Care Unit Patients with Severe Sepsis.

Mar 20, 2020

Recommended time to start administration of first dose antibiotics for sepsis patients is 60 minutes from time 0. Institution-specific data revealed that only one-quarter of severe sepsis patients wer...

Management of Iatrogenic Cervical Esophageal Perforations: A Narrative Review.

Mar 20, 2020

Esophageal perforations are difficult to diagnose and have a high mortality rate. Cervical esophageal perforations (CEPs) are the second most common anatomic type of esophageal perforations and are mo...

Effect of Antibiotic Discontinuation Strategies on Mortality and Infectious Complications in Critically Ill Septic Patients: A Meta-analysis and Trial Sequential Analysis.

Mar 20, 2020

To investigate methods of antibiotic duration minimization and their effect on mortality and infectious complications in critically ill patients.A systematic search of PubMed, Embase (via Ovid), clini...

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