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Critical Care General

ICU-acquired Pneumonia: Definitions, Incidence, Prevalence, and Mortality

Apr 27, 2023

The following is a summary of “Definitions, rates and associated mortality of ICU-acquired pneumonia: A multicenter cohort study,” published in the April 2023 issue of Critical Care by Johnstone e...

Clostridioides Difficile Infection among Critically Ill Patients on Mechanical Ventilation

Apr 27, 2023

The following is a summary of “Clostridioides difficile infection in mechanically ventilated critically ill patients: A nested cohort study,” published in the April 2023 issue of Critical Care by ...

Moderate-to-Severe COPD: Therapeutic Response to SITT

Apr 24, 2023

The following is a summary of “Therapeutic Response to Single-Inhaler Triple Therapies in Moderate-to-Severe COPD,” published in the March 2023 issue of Respiratory Care by Ohtsuka et al.  ...

[Influencing factors of small intestinal ischemia in elderly patients with incarcerated hernia].

Apr 24, 2023

To investigate the factors influencing small intestinal ischemia in elderly patients with incarcerated hernia. The clinical data of 105 elderly patients admitted for surgical procedures of incarcera...

Rnf144b alleviates the inflammatory responses and cardiac dysfunction in sepsis.

Apr 24, 2023

Sepsis is an inflammatory disease with high mortality and morbidity. Inflammation plays an essential role in sepsis, and suppressing inflammation has been shown to ameliorate sepsis. Rnf144b is an ubi...

Activities of a broad-spectrum antimicrobial peptide analogue SAMP-A4-C8 and its combat against pneumonia in Staphylococcus aureus infected mice.

Apr 24, 2023

Antimicrobial peptides and their analogues have become substitutes for antibiotics in recent years. The antimicrobial peptide analogue SAMP-A4-C8 (n-octanoic-VRLLRRRI) with high antimicrobial activity...

Effect of low-to-moderate hyperoxia on lung injury in preclinical animal models: a systematic review and meta-analysis.

Apr 24, 2023

Extensive animal investigation informed clinical practice regarding the harmful effects of high fractional inspired oxygen concentrations (FiOs > 0.60). Since questions persist whether lower bu...

Single versus dual antibiotic regimen in women with term prolonged rupture of membranes and intrapartum fever: a retrospective study.

Apr 24, 2023

The impact of E. coli in causing peripartum infections has been increasing due to rising ampicillin resistance. In this study, we compared maternal and neonatal outcomes of women with prolonged ruptu...

Identification of a novel gene signature for the prognosis of sepsis.

Apr 24, 2023

Sepsis is a life-threatening organ dysfunction caused by the host's dysfunctional response to infection, and its pathogenesis is still unclear. In view of the complex pathological process of sepsis, f...

Traumatic brain injury as a chronic disease: insights from the United States Traumatic Brain Injury Model Systems Research Program.

Apr 24, 2023

Traumatic brain injury (TBI) is a global health priority, associated with substantial burden. Historically conceptualised as an injury event with finite recovery, TBI is now recognised as a chronic co...

Impact of NIV on Oxygen Levels in Peripheral and Respiratory Muscles During High-intensity Exercise

Apr 21, 2023

The following is a summary of “ Effect of Adding Non-invasive Ventilation to High-Intensity Exercise on Peripheral and Respiratory Muscle Oxygenation," published in the March 2023 issue of Respirato...

Assessing Postextubation Stridor: The Role of Risk Stratification and Cuff Leak Testing

Apr 20, 2023

The following is a summary of “Utilization of a Risk Stratification Tool and Volume-Based Cuff Leak Test to Assess Postextubation Stridor," published in the March 2023 issue of Respiratory Care by ...

Inhaled Sedation: A Promising Treatment for Severe ARDS in COVID-19 Patients

Apr 19, 2023

The following is a summary of "Usefulness of Inhaled Sedation in Patients With Severe ARDS Due to COVID-19," published in the March 2023 issue of Respiratory Care by Duque et al.  The administ...

Modeling Optimal Tracheostomy Timing Based on Vocal Cord Injury Severity

Apr 18, 2023

The following is a summary of the “Optimal Tracheostomy Timing Through Modeling Based on Severity of Vocal Cord Injury,” published in the February 2023 issue of Respiratory Care by Malkoc, et al. ...

Yap1-Usp14 Axis Inhibits Neuronal Mitophagy During Neonatal Hypoxia-Ischemia Encephalopathy by Regulation of Beclin-1 Ubiquitination in Mouse.

Apr 17, 2023

Neonatal hypoxic-ischemic encephalopathy (HIE) that results from perinatal cerebral hypoxia-ischemia has become one of the leading causes of acute mortality and chronic disability in infants and child...

Survival of Streptococcus equi subsp. zooepidemicus on environmental samples is affected by material type and incubation temperature.

Apr 17, 2023

Streptococcus equi subsp. zooepidemicus is an opportunistic pathogen associated with disease in a range of domestic and wild animals. Despite its importance, very limited data is available on its surv...

CRISPR/Cas9-based point-of-care lateral flow biosensor with improved performance for rapid and robust detection of Mycoplasma pneumonia.

Apr 17, 2023

Screening of acute respiratory infections causes serious challenges in urgent point-of-care scenarios where conventional methods are impractical and alternative techniques suffer from low accuracy, po...

EXCHANGE-2: investigating the efficacy of add-on plasma exchange as an adjunctive strategy against septic shock-a study protocol for a randomized, prospective, multicenter, open-label, controlled, parallel-group trial.

Apr 17, 2023

Sepsis is as a life-threatening organ dysfunction caused by a dysregulated host response to an infection. The mortality of sepsis and particular of septic shock is very high. Treatment mostly focuses ...

Shengjiang San alleviated sepsis-induced lung injury through its bidirectional regulatory effect.

Apr 17, 2023

Sepsis is a life-threatening organ dysfunction caused by dysregulated host responses to infection, for which effective therapeutic strategies are still absent. Shengjiang San (SJS), a well-known Tradi...

Hippocampal demyelination is associated with increased magnetic susceptibility in a mouse model of concussion.

Apr 17, 2023

Structural and functional deficits in the hippocampus are a prominent feature of moderate-severe traumatic brain injury (TBI). In this work, we investigated the potential of Quantitative Susceptibilit...

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