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Critical Care General

Psychogenic nonepileptic seizures in children-Prospective validation of a clinical care pathway & risk factors for treatment outcome.

Mar 04, 2020

The purpose of this study was to prospectively validate a care pathway for psychogenic nonepileptic seizures (PNES) in a pediatric setting. The pathway was developed based on a previous study of patie...

Pulmonary Complications and Sepsis Following Severe Acute Subdural Hematoma in Patients Who Underwent Craniotomy versus Craniectomy: A Propensity Score Matched Analysis.

Mar 04, 2020

 The purpose of the study was to evaluate the impact of craniotomy (CO) and decompressive craniectomy (DC) for evacuation of acute subdural hematoma (SDH) on pulmonary complications and sepsis. St...

Design of the SILICOFCM study: Effect of sacubitril/valsartan vs lifestyle intervention on functional capacity in patients with hypertrophic cardiomyopathy.

Mar 04, 2020

Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiovascular disease with a broad spectrum of disease severity. HCM ranges from a benign course to a progressive disorder characterized b...

The relevance of a multidomain geriatric assessment in older patients with heart failure.

Mar 04, 2020

Physical frailty screening is more commonly performed at outpatient heart failure (HF) clinics. However, this does not incorporate other common geriatric domains. This study assesses whether a multido...

Heart failure after pressure overload in autosomal-dominant desminopathies: Lessons from heterozygous DES-p.R349P knock-in mice.

Mar 04, 2020

Mutations in the human desmin gene (DES) cause autosomal-dominant and -recessive cardiomyopathies, leading to heart failure, arrhythmias, and AV blocks. We analyzed the effects of vascular pressure ov...

[Lights and shadows of combined epigenomic and transcriptomic profiling to identify novel diagnostic, prognostic or therapeutic targets for cardiovascular diseases.]

Mar 04, 2020

Cardiovascular diseases are the major cause of morbidity and mortality worldwide. Given the complex pathophysiology of cardiovascular diseases, an experimental approach capable of identifying multiple...

Simulation Training for Critical Care Airway Management: Assessing Translation to Clinical Practice Using a Small Video Recording Device.

Mar 04, 2020

Critical care airway management (CCAM) is a key skill for critical care physicians. Simulation based training (SBT) may be an effective modality in training intensivists in CCAM.This study examines wh...

β-alanine and L-histidine supplementation associated with combined training increased functional capacity and maximum strength in heart failure rats.

Mar 04, 2020

Combined training (CT) has been associated with positive responses in the clinical status of patients with chronic heart failure (CHF). Other non-pharmacological tools, such as amino acid supplementat...

Clinical profile of aetiological and risk factors of young adults with ischemic stroke in West China.

Mar 04, 2020

Our study aimed to present the clinical characteristics of aetiological and risk factors of ischemic stroke (IS) in young adults in order to provide reference to the early prevention and management.Da...

Iron Sucrose as MRI Contrast Agent in Ischemic Stroke Model.

Mar 02, 2020

Despite the growing concern about the safety of gadolinium-based contrast agents (GBCAs), they are still the most commonly used. Ferumoxytol, as an off-label alternative MRI contrast agent, cannot be ...

Musk ketone induces neural stem cell proliferation and differentiation in cerebral ischemia via activation of the PI3K/Akt signaling pathway.

Mar 02, 2020

Traditional Chinese medicine has been reported to influence the proliferation and differentiation of neural stem cells (NSCs) that may be protective against nervous system diseases. Recent evidence in...

Neuroprotective effects of saffron on the late cerebral ischemia injury through inhibiting astrogliosis and glial scar formation in rats.

Mar 02, 2020

This study is to explore the neuroprotective effects and involved glial scar of saffron (Crocus sativus L.) on the late cerebral ischemia in rats. Focal cerebral ischemia was induced by middle cerebra...

Zebrafish GSDMEb Cleavage-Gated Pyroptosis Drives Septic-Acute Kidney Injury In Vivo.

Mar 02, 2020

The bacteria LPS is one of the leading endotoxins responsible for sepsis; its sensing pathway-induced pyroptosis plays an important role in innate immunity. However, excessive pyroptosis might cause i...

Gradient acoustic focusing of sub-micron particles for separation of bacteria from blood lysate.

Mar 02, 2020

Handling of submicron-sized objects is important in many biochemical and biomedical applications, but few methods today can precisely manipulate this range of particles. We present gradient acoustic f...

All change in the prostate cancer diagnostic pathway.

Mar 02, 2020

Following detection of high levels of serum prostate-specific antigen, many men are advised to have transrectal ultrasound-guided biopsy in an attempt to locate a cancer. This nontargeted approach lac...

Sepsis in Burned Adult Patients: Study of Serie of Cases in Brazil.

Mar 02, 2020

Sepsis is currently the leading cause of death in burned patients. There are few studies on sepsis in burned patients at Intensive Care Unit (ICU).To determine demographic profile, clinical presentati...

IL-17 production by tissue-resident MAIT cells is locally induced in children with pneumonia.

Mar 02, 2020

Community-acquired pneumonia (CAP) contributes substantially to morbidity and mortality in children under the age of 5 years. In examining bronchoalveolar lavages (BALs) of children with CAP, we found...

Long-term swallowing, trismus, and speech outcomes after combined chemoradiotherapy and preventive rehabilitation for head and neck cancer; 10-year plus update.

Mar 02, 2020

The objective of this study was to explore the 10-year plus outcomes of Intensity Modulated Radiotherapy with concomitant chemotherapy (CRT) combined with preventive swallowing rehabilitation (CRT+) f...

Nepal: country report on children's environmental health.

Mar 02, 2020

Although Nepal is a country rich in natural beauty, along with an abundance of natural resources, the children of this diverse nation still face several serious health issues arising from their own en...

Characteristics of COVID-19 infection in Beijing.

Mar 02, 2020

Since the first case of a novel coronavirus (COVID-19) infection pneumonia was detected in Wuhan, China, a series of confirmed cases of the COVID-19 were found in Beijing. We analyzed the data of 262 ...

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