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Critical Care General

Differential Effects of MitoVitE, α-Tocopherol and Trolox on Oxidative Stress, Mitochondrial Function and Inflammatory Signalling Pathways in Endothelial Cells Cultured under Conditions Mimicking Sepsis.

Mar 02, 2020

Sepsis is a life-threatening response to infection associated with inflammation, oxidative stress and mitochondrial dysfunction. We investigated differential effects of three forms of vitamin E, which...

Analytical Evaluation of the New Beckman Coulter Access Procalcitonin (PCT) Chemiluminescent Immunoassay.

Mar 02, 2020

This study was designed to evaluate the analytical performance of the recently commercialized Beckman Coulter Access procalcitonin (PCT) chemiluminescent test on the Access immunoassay system. The ana...

Pre-treatment with IL2 gene therapy alleviates Staphylococcus aureus arthritis in mice.

Mar 02, 2020

Staphylococcus aureus (S. aureus) arthritis is one of the most detrimental joint diseases known and leads to severe joint destruction within days. We hypothesized that the provision of auxiliary immun...

Anti-pituitary and anti-hypothalamus autoantibody associations with inflammation and hypogonadotropic hypogonadism in men with traumatic brain injury.

Mar 02, 2020

Traumatic brain injury (TBI) and can lead to persistent hypogonadotropic hypogonadism (PHH) and poor outcomes. We hypothesized that autoimmune and inflammatory mechanisms contribute to PHH pathogenesi...

Is Pediatric Traumatic Brain Injury Associated with Adult Alcohol Misuse?

Mar 02, 2020

Evidence suggests that pediatric traumatic brain injury (TBI) may be causally related to alcohol misuse later in life; however, the nature and extent of the association has not been well described. Th...

Head injury and helmet usage trends for alpine skiers and snowboarders in western Canada during the decade 2008-9 to 2017-18.

Mar 02, 2020

This research explores snowsport head injury trends in western Canadian resorts over the decade 2008-2018.Ecological study.Head-injury and participation data on alpine skiing and snowboarding (snowspo...

Necrostatin-1 prevents the proapoptotic protein Bcl-2/adenovirus E1B 19-kDa interacting protein 3 from integration into mitochondria.

Mar 02, 2020

Necrostatin-1 (Nec-1) has previously been shown to protect neurons from death in traumatic and ischemic brain injuries. The present study tests the hypothesis that Nec-1 protects neural cells against ...

Alcohol Use Disorders and the Brain.

Mar 02, 2020

A diagnosis of alcohol use disorder is associated with a higher risk of dementia but a dose-response relationship between alcohol intake consumption and cognitive impairment remains unclear. Alcohol i...

Copeptin - a new diagnostic and prognostic biomarker in neurological and cardiovascular diseases.

Mar 02, 2020

Copeptin, arginine vasopressin (AVP)-associated 39 aminoacid glycopeptide, is a C-terminal part of pro-AVP. AVP acts through V1a, V1b, and V2 receptors. The effect on V1a receptors is connected with ...

INCREASED RISK OF SEVERE MATERNAL MORBIDITY AMONG INFERTILE WOMEN: ANALYSIS OF US CLAIMS DATA.

Mar 02, 2020

Severe maternal morbidity continues to be an issue of national and global concern and is increasing in incidence. The incidence of infertility is also on the rise, and infertile women experience a hig...

Dihydromyricetin alleviates doxorubicin-induced cardiotoxicity by inhibiting NLRP3 inflammasome through activation of SIRT1.

Mar 02, 2020

Doxorubicin (DOX) is a powerful anthracycline antineoplastic drug whose clinical application is limited by serious cardiotoxic side effects. Dihydromyricetin (DHM), a flavonoid compound extracted from...

Nasal colonization with Staphylococcus aureus is a risk factor for ventricular assist device infection in the first year after implantation: a prospective, single-centre, cohort study.

Mar 02, 2020

To assess, whether S. aureus nasal colonization is a risk factor for infections in patients with durable ventricular assist device (VAD).Prospective, single-centre, cohort study (i) ascertaining S. au...

Case of internal jugular vein thrombosis and fever: Lemierre's syndrome or Trousseau's syndrome?

Mar 02, 2020

Internal jugular vein thrombosis is a rare critical cardiovascular emergency, which has potential catastrophic clinical outcomes by resulting in stroke and pulmonary embolism. Several etiologies have ...

Rivaroxaban versus warfarin in patients with nonvalvular atrial fibrillation and stage IV-V chronic kidney disease.

Mar 02, 2020

There is limited evidence on the effectiveness and safety of direct-acting oral anticoagulants in patients with nonvalvular atrial fibrillation (NVAF) and advanced chronic kidney disease (CKD). This s...

Ischemic postconditioning exerts neuroprotective effect through negatively regulating PI3K/Akt2 signaling pathway by microRNA-124.

Mar 02, 2020

Ischemic stroke is a serious threat to human life and health, which is often accompanied by cerebral ischemia-reperfusion (I/R) injury in clinic. Ischemic postconditioning (IPostC) is a short period o...

Predicting long-term cardiovascular outcomes of patients with acute myocardial infarction using soluble ST2.

Mar 02, 2020

Background The increase in soluble suppression of tumorigenicity 2 (sST2) both in the diagnosis and prognosis of heart failure is well established; however, existing data regarding sST2 values as the ...

EXTRA-CORPOREAL MEMBRANE OXYGENATION FOR NEONATAL RESPIRATORY SUPPORT.

Mar 02, 2020

To review our experience with Extra-Corporeal Membrane Oxygenation (ECMO) for respiratory support in neonates. From 1989 to 2018 2,114 patients underwent respiratory ECMO support, with 764(36%) neonat...

The effect of the economic collapse in Iceland on the probability of cardiovascular events.

Feb 28, 2020

After several years of a booming economy in Iceland, the economic bubble burst in 2008 and affected most Icelanders in one way or another. We explore whether the economic collapse in 2008 and subseque...

Prevalence and Prognostic Impact of Hypernatremia in Sepsis and Septic Shock Patients in the Intensive Care Unit: A Single Centre Experience.

Feb 28, 2020

Hypernatremia is a commonly associated electrolyte disturbance in sepsis and septic shock patients in the ICU. The objective of this study was to identify the prognostic value of hypernatremia in seps...

CircPRKCI relieves lipopolysaccharide-induced HK2 cell injury by upregulating the expression of miR-545 target gene ZEB2.

Feb 28, 2020

The aim of this study was to investigate the possible influences of circPRKCI abnormal expression on lipopolysaccharide (LPS)-induced HK2 cell injury and its mechanism. The circPRKCI level was identif...

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