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Critical Care General

Complement interactions with the pathogenic Neisseriae: clinical features, deficiency states and evasion mechanisms.

Feb 18, 2020

Neisseria gonorrhoeae causes the sexually transmitted infection gonorrhea, while Neisseria meningitidis is an important cause of bacterial meningitis and sepsis. Complement is a central arm of innate ...

Peri- and Post-operative Amplitude-integrated Electroencephalography in Infants with Congenital Heart Disease.

Feb 18, 2020

To identify the factors influencing brain injury in infants with congenital heart disease (CHD) after cardiac surgery.This retrospective study investigated 103 infants with CHD undergoing cardiac surg...

[Treatment strategies and outcomes for injection-associated inguinal perivascular abscesses in intravenous drug addicts].

Feb 18, 2020

Long-term drug users regularly present with deep inguinal vascular-associated abscesses due to continued drug injections utilizing superficial veins. The treatment of these complications continues to ...

Effects of RO27-3225 on neurogenesis, PDGFRβ cells and neuroinflammation after cerebral infarction.

Feb 18, 2020

Cerebral infarction causes severe social and economic burdens to patients due to its high morbidity and mortality rates, and the available treatments are limited. RO27-3225 is a highly selective melan...

Occupant injuries in light passenger vehicles-A NASS study to enable priorities for development of injury prediction capabilities of human body models.

Feb 18, 2020

To prioritize how the development of mathematical human body models for injury prediction in crash safety analysis should be made, the most frequent injuries in the NASS CDS data from 2000 to 2015 wer...

Differential Expression of Circulating Inflammatory Proteins Following Sport-Related Traumatic Brain Injury.

Feb 18, 2020

Sport-related traumatic brain injury (TBI) elicits a multifaceted inflammatory response leading to brain injury and morbidity. This response could be a predictive tool for the progression of TBI and t...

Changes in macrophage inflammatory protein-1 (MIP-1) family members expression induced by traumatic brain injury in mice.

Feb 18, 2020

A deep knowledge of the profound immunological response induced by traumatic brain injury (TBI) raises the possibility of novel therapeutic interventions. Existing studies have highlighted the importa...

Serum Amyloid A is Expressed in the Brain After Traumatic Brain Injury in a Sex-Dependent Manner.

Feb 18, 2020

Serum amyloid A (SAA) is an acute phase protein upregulated in the liver after traumatic brain injury (TBI). So far, it has not been investigated whether SAA expression also occurs in the brain in res...

Short-term effects of low-dose tolvaptan in acute decompensated heart failure patients with severe aortic stenosis: The LOHAS registry.

Feb 18, 2020

Tolvaptan exerts potent diuretic effects in heart failure patients without hemodynamic instability. Nonetheless, its clinical efficacy for acute decompensated heart failure (ADHF) due to severe aortic...

Mechanisms of left ventricular dyssynchrony: A multinational SPECT study of patients with bundle branch block.

Feb 18, 2020

To better understand the mechanisms of left ventricular (LV) mechanical dyssynchrony (LVMD), we explored the relative contributions of QRS duration (QRSd), LV ejection fraction (EF), volumes and scar ...

Incremental value of myocardial wall motion and thickening to perfusion alone by gated SPECT myocardial perfusion imaging for viability assessment in patients with ischemic heart failure.

Feb 18, 2020

The objective of this study was to assess the incremental value of myocardial wall motion and thickening compared with perfusion alone obtained from gated single-photon emission computed tomography (S...

Inpatient Mortality and 30-Day Readmission Rates Associated with Troponin Testing in Patients without Acute Myocardial Infarction.

Feb 18, 2020

Troponin values above the threshold established to diagnose acute myocardial infarction (AMI; >99 percentile) are commonly detected in patients with diagnoses other than AMI. The objective of this stu...

Cardiac protection of Bauhinia championii against reperfusion injury.

Feb 18, 2020

This study aims to investigate the protective effects of the Bauhinia championii (BC) against ischemia/reperfusion (I/R)-induced injury in an isolated heart model. Langendorff-perfused C57BL/6JNarl mi...

Data-driven discovery of changes in clinical code usage over time: a case-study on changes in cardiovascular disease recording in two English electronic health records databases (2001-2015).

Feb 18, 2020

To demonstrate how data-driven variability methods can be used to identify changes in disease recording in two English electronic health records databases between 2001 and 2015.Repeated cross-sectiona...

The First Disease X is Caused by a Highly Transmissible Acute Respiratory Syndrome Coronavirus.

Feb 18, 2020

Based on the announcement of the World Health Organization (WHO) in 2018, the Wuhan pneumonia caused by an unknown etiology should be recognized as the first Disease X. Later, the pathogen was identif...

Prophylactic use of acid suppressants in adult acutely ill hospitalised patients: a systematic review with meta-analysis and trial sequential analysis.

Feb 18, 2020

Acutely ill patients are at risk of stress-related gastrointestinal bleeding and prophylactic acid suppressants are frequently used. In this systematic review, we assessed the effects of stress ulcer ...

[Inhibitors of RAS Might Be a Good Choice for the Therapy of COVID-19 Pneumonia].

Feb 18, 2020

The novel coronavirus 2019 (COVID-19) infected patients by binding human ACE2, leading to severe pneumonia and highly mortality rate in patients. At present, there is no definite and effective treatme...

The Dutch influenza vaccination policy and medication use, outpatient visits, hospitalization and mortality at age 65.

Feb 17, 2020

Our objective was to obtain estimates of the impact of the Dutch vaccination programme on medication use, outpatient visits, hospitalization and mortality at age 65.We linked population-wide mortality...

[Clinical features of 2019 novel coronavirus pneumonia in the early stage from a fever clinic in Beijing].

Feb 17, 2020

To summarize and analyze the clinical and imaging characteristics of patients with 2019 novel coronavirus pneumonia in the early stage in Beijing. A retrospective analysis of clinical and imaging da...

Hyperbaric oxygen (HBO) therapy as an effective approach to the treatment of patients with severe idiopathic sudden sensorineural hearing loss.

Feb 13, 2020

The potential etiology of idiopathic sudden sensorineural hearing loss (ISSNHL) is cochlear ischemia, therefore, hyperbaric oxygen (HBO) therapy is a promising treatment, particularly in patients wit...

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