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Critical Care General

Effects of hyperoxemia in patients with sepsis - A post-hoc analysis of a multicentre randomized clinical trial.

Mar 13, 2023

Administration of supplemental oxygen is a life-saving treatment in critically ill patients. Still, optimal dosing remains unclear during sepsis. The aim of this post-hoc analysis was to assess the as...

Knockdown of adenosine A2A receptors in hippocampal neurons prevents post-TBI fear memory retrieval.

Mar 13, 2023

The formation of fear memory is crucial in emotional disorders such as PTSD and anxiety. Traumatic brain injury (TBI) can cause emotional disorders with dysregulated fear memory formation; however, th...

Beyond uncal herniation: An updated diagnostic reappraisal of ipsilateral hemiparesis and the Kernohan-Woltman notch phenomenon.

Mar 13, 2023

This works comprehensively analyses a modern cohort of patients with ipsilateral hemiparesis (IH) and discusses the pathophysiological theories elaborated to explain this paradoxical neurological sign...

Diagnostic Pathways to Wild-Type Transthyretin Amyloid Cardiomyopathy: a Multicenter Network Study.

Mar 13, 2023

Epidemiology of wild-type transthyretin cardiac amyloidosis (ATTRwt-CA) remains poorly defined. A better characterization of pathways leading to ATTRwt-CA diagnosis is of key importance, and potential...

Critically ill severe hypothyroidism: a retrospective multicenter cohort study.

Mar 13, 2023

Severe hypothyroidism (SH) is a rare but life-threatening endocrine emergency. Only a few data are available on its management and outcomes of the most severe forms requiring ICU admission. We aimed t...

Limitations of Breath-by-Breath P0.1 Measurement on Quasi-occlusion through Hamilton C6: Underestimation of Inspiratory Effort and Respiratory Drive

Mar 10, 2023

The following is the summary of “Breath-by-breath P0.1 measured on quasi-occlusion via Hamilton C6 may result in underestimation of respiratory drive and inspiratory effort” published in the Decem...

Assessment and Rate of Muscle Wasting During Illness

Mar 09, 2023

The following is the summary of “Rate and assessment of muscle wasting during critical illness: a systematic review and meta-analysis” published in the January 2023 issue of Critical care by Fazzi...

GCSE Adjuvant Treatment in Valproic Acid During Clinical Trial

Mar 07, 2023

The following is the summary of “Valproic acid as adjuvant treatment for convulsive status epilepticus: a randomised clinical trial” published in the January 2023 issue of Critical care by Sharsha...

Baricitinib's Effectiveness and Safety in Treating Hospitalized Adults with Severe COVID-19

Mar 06, 2023

The following is the summary of “Efficacy and safety of baricitinib in hospitalized adults with severe or critical COVID-19 (Bari-SolidAct): a randomized, double-blind, placebo-controlled phase 3 tr...

Subcutaneous implantable cardioverter-defibrillator therapy in Poland: Results of the Polish S-ICD Registry.

Mar 06, 2023

The use of a subcutaneous implantable cardioverter-defibrillator (S-ICD) has been expanding in Poland since 2014. The Polish Registry of S-ICD Implantations was held by the Heart Rhythm Section of the...

Intensification of treatment with vinca alkaloid does not improve outcomes in pediatric patients with Langerhans cell histiocytosis: results from the JPLSG LCH-12 study.

Mar 06, 2023

Chemotherapy with cytarabine, vincristine (VCR), and prednisolone has achieved low mortality rates in pediatric patients with Langerhans cell histiocytosis (LCH). However, relapse rates remain high, m...

Identification and quantification of nine compounds in fangwen jiuwei decoction by liquid chromatography-mass spectrometry.

Mar 06, 2023

Fangwen Jiuwei Decoction is a traditional Chinese medicine preparation for the treatment of pneumonia developed by Shenzhen Bao'an Chinese Medicine Hospital, which shows remarkable clinical responses....

Extremely high unbound flucloxacillin concentrations in a patient with acute septic renal failure during continuous venovenous hemofiltration: Therapeutic drug monitoring to optimize treatment.

Mar 06, 2023

A 75-year-old female orthopedic patient with spondylodiscitis was admitted to the intensive care unit, where she developed severe acute renal injury (AKI) due to a bloodstream infection. Continuous v...

Association between gut microbiota and delirium in acutely ill older adults.

Mar 06, 2023

Our aim was to investigate the association between gut microbiota and delirium occurrence in acutely ill older adults. We included 133 participants 65+ years consecutively admitted to the emergency de...

Trends in Traumatic Brain Injury Among U.S. Service Members Deployed in Iraq and Afghanistan, 2002-2016.

Mar 06, 2023

Traumatic brain injury (TBI) is a major health issue for service members deployed and is more common in recent conflicts; however, a thorough understanding of risk factors and trends is not well descr...

Colorectal Cancer-Related Enterostomy Patients' Psychological Distress

Mar 03, 2023

The following is a summary of "Predictors of Psychological Distress among Patients with Colorectal Cancer-Related Enterostomy: A Cross-sectional Study," published in the February 2023 issue of Critica...

Clinical Outcomes of COPD During Continuous Monitoring of Pulse Oximetry

Mar 02, 2023

The following is the summary of “Continuous Monitoring of Pulse Oximetry During the 6-Minute Walk Test Improves Clinical Outcomes Prediction in COPD” published in the January 2023 issue of Respira...

Corticosteroids' Effectiveness and Safety in Cardiac Arrest

Mar 01, 2023

The following is the summary of “Efficacy and safety of corticosteroids in cardiac arrest: a systematic review, meta-analysis and trial sequential analysis of randomized control trials” published ...

Bundle of ‘THE MANTLE’ to Minimize Cerebral Hypoxia in Severe Traumatic Brain Injury

Feb 28, 2023

The following is the summary of “THE MANTLE” bundle for minimizing cerebral hypoxia in severe traumatic brain injury” published in the January 2023 issue of Critical care by Godoy, et al. ...

Comparing Prolonged Sedation With IV Sedation and Sevoflurane in Critically Ill Patients

Feb 27, 2023

The following is the summary of “Prolonged sedation with sevoflurane in comparison to intravenous sedation in critically ill patients – A randomized controlled trial” published in the January 20...

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