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Critical Care General

Role of OPG/RANKL/RANK/TLR4 signaling pathway in sepsis-associated acute kidney injury.

Jun 24, 2024

Sepsis-associated acute kidney injury (SA-AKI) has high mortality rates. The osteoprotegerin (OPG)/receptor activator of nuclear factor-κB ligand (RANKL)/receptor activator of nuclear factor-κB (RAN...

Macrophage biomimetic nanoparticle-targeted functional extracellular vesicle micro-RNAs revealed via multiomics analysis alleviate sepsis-induced acute lung injury.

Jun 24, 2024

Patients who suffer from sepsis typically experience acute lung injury (ALI). Extracellular vesicles (EVs) contain miRNAs, which are potentially involved in ALI. However, strategies to screen more eff...

Machine Learning: A Potential Therapeutic Tool to Facilitate Neonatal Therapeutic Decision Making.

Jun 17, 2024

Bacterial infection is one of the major causes of neonatal morbidity and mortality worldwide. Finding rapid and reliable methods for early recognition and diagnosis of bacterial infections and early i...

Pediatric ultrasound practice in Italy: an exploratory survey.

Jun 10, 2024

The aim of this exploratory survey is to describe the current state of US (ultrasound) technique across different pediatric settings nationwide.A questionnaire was emailed to all members of the Italia...

Epidemiology of pediatric spinal trauma with neurological deficits in Catalonia: a 36-year experience.

Jun 10, 2024

Existing literature on pediatric traumatic spinal cord injury (PTSCI) demonstrates large variations in characteristics, incidence, time-periods and etiology, worldwide. Epidemiological studies address...

Concussion and the Sleeping Brain.

Jun 10, 2024

Emerging research has suggested sleep to be a modifier of the trajectory of concussion recovery in adolescent and adult populations. Despite the growing recognition of the relationship between sleep a...

Hypertonic Saline Reasonable Alternative to Mannitol for Intracranial Pressure Reduction in Patients With Traumatic Brain Injury

Jun 06, 2024

Controlling elevated intracranial pressure following brain injury with hyperosmolar agents is one of the mainstay treatments in traumatic brain injury patients. In this study, we compared the effects ...

Synaptic Damage Markers Acutely Elevated in Severe TBI, Predict Longterm Outcomes

Jun 05, 2024

Biomarkers of neuronal, glial cells and inflammation in traumatic brain injury (TBI) are available but they do not specifically reflect the damage to synapses, which represent the bulk volume of the b...

Enzyme-Linked Immunosorbent Assay Accurately Measures Regenerating Island-Derived Protein 3E in Canine Blood

Jun 03, 2024

Regenerating island-derived proteins (REG) are upregulated in people with sepsis, pancreatitis, and gastrointestinal diseases. One member of the REG family, namely REG3E, was recently identified in pa...

Impella support for refractory cardiogenic shock accompanied by diabetic ketoacidosis: a case report.

May 27, 2024

Sodium-glucose cotransporter 2 (SGLT2) inhibitors are strongly recommended in patients with heart failure, regardless of the presence of diabetes mellitus. A 74 year-old woman with a reduced left ven...

Hospital admission and mortality rates for ischemic heart disease in Thailand: 2012-2021.

May 20, 2024

To provide an update on the epidemiology of ischemic heart disease (IHD), including the age-standardized rates of hospital admission and mortality for IHD in Thailand from 2012 to 2021, using the Mini...

The incidence and factors associated with anemia in elective surgical patients admitted to a surgical intensive care unit: a retrospective cohort study.

May 20, 2024

Anemia is a frequently reported and commonly documented issue in intensive care units. In surgical intensive care units, more than 90% of patients are found to be anemic. It is a hematologic factor th...

The impact of inhalation injury on fluid resuscitation in major burn patients: a 10-year multicenter retrospective study.

May 13, 2024

It remains unclear whether additional fluid supplementation is necessary during the acute resuscitation period for patients with combined inhalational injury (INHI) under the guidance of the Third Mil...

Cefiderocol in Difficult-to-Treat Nf-GNB in ICU Settings.

May 13, 2024

The efficacy and safety of cefiderocol in ICU patients with difficult-to-treat resistance (DTR) non-fermenting Gram-negative bacteria (Nf-GNB) are not as well-established. Consequently, we conducted a...

Mapping dynamic molecular changes in hippocampal subregions after traumatic brain injury through spatial proteomics.

May 13, 2024

Traumatic brain injury (TBI) often results in diverse molecular responses, challenging traditional proteomic studies that measure average changes at tissue levels and fail to capture the complexity an...

Management of Anticoagulation and Antifibrinolytics in Catastrophic Antiphospholipid Syndrome.

May 06, 2024

Antiphospholipid syndrome (APS) is an autoimmune disorder that presents with hypercoagulability and results in a lab artifact of prolonged PTT. The most severe form is catastrophic antiphospholipid an...

Association of stress hyperglycemia ratio and mortality in patients with sepsis: results from 13,199 patients.

Apr 29, 2024

The stress hyperglycemia ratio (SHR), adjusted for average glycemic status, is suggested for assessing actual blood glucose levels. Its link with adverse outcomes is known in certain populations, yet ...

Short-term outcomes after liver resection with vascular reconstruction: Results from a study with the National Clinical Database of Japan.

Apr 29, 2024

Although curative resection with vascular reconstruction improves the prognosis of blood-invading locally advanced hepatobiliary tumors, the mortality and morbidity of the procedure remains unclear. T...

Short-term variation of the fetal heart rate as a marker of intraamniotic infection in pregnancies with preterm prelabor rupture of membranes: a historical cohort study.

Apr 29, 2024

Intraamniotic infection (IAI) and subsequent early-onset neonatal sepsis (EONS) are among the main complications associated with preterm prelabor rupture of membranes (PPROM). Currently used diagnosti...

Excessive fat expenditure in MCT-induced heart failure rats is associated with BMAL1/REV-ERBα circadian rhythmic loop disruption.

Apr 08, 2024

Fat loss predicts adverse outcomes in advanced heart failure (HF). Disrupted circadian clocks are a primary cause of lipid metabolic issues, but it's unclear if this disruption affects fat expenditure...

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