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Critical Care General

How to Best Prevent Central Line-Associated Bloodstream Infections

May 18, 2022

The following was originally posted to the University of Nebraska Medical Center Division of Infectious Diseases blog.     Dr. Rupp recently assisted in the creation of ne...

A standardized implementation of multicenter quality improvement program of very low birth weight newborns could significantly reduce admission hypothermia and improve outcomes.

May 16, 2022

Admission hypothermia (AH, < 36.5℃) remains a major challenge for global neonatal survival, especially in developing countries. Baseline research shows nearly 89.3% of very low birth weight (...

Innate immune signalling and immunothrombosis: New insights and therapeutic opportunities.

May 16, 2022

Activation of the coagulation cascade is a critical, evolutionarily conserved mechanism that maintains haemostasis by rapidly forming blood clots in response to blood-borne infections and damaged bloo...

The mortality predicting ability of chest X-ray severity scoring systems in Covid-19 pneumonia.

May 16, 2022

Although several chest X-ray (CXR) severity scoring systems are in use to assess Covid-19 pneumonia (CP), inhomogeneity has been observed among the assessment methodologies.To describe and validate se...

Protein kinase G phosphorylation of Chip protects ovariectomized females from myocardial infarction.

May 16, 2022

Proteotoxicity from insufficient clearance of misfolded/damaged proteins exacerbates cardiac functional decline following a myocardial infarction (MI). Estrogen is known to play a crucial role in the ...

Myeloid Expressed Epidermal Growth Factor Receptor (EGFR) is Critical to Heart Homeostasis and Limits Adverse Outcomes Following Ischemic Attack.

May 16, 2022

The healthy heart comprises immune cells, mainly macrophages of differing class and origin. While these myeloid cells remain an area of continuous investigation, we have come to appreciate that a subs...

Effectiveness of an Active and Continuous Surveillance Program for Intensive Care Units Infections Based on the EPIC III (Extended Prevalence of Infection in Intensive Care) Approach.

May 16, 2022

We evaluated the effectiveness of the Extended Prevalence of Infection in Intensive Care (EPIC) III data collection protocol as an active surveillance tool in the eight Intensive Care Units (ICUs) of ...

Rescue venovenous extracorporeal membrane oxygenation for the deterioration of acute respiratory distress syndrome in pediatric liver transplantation.

May 16, 2022

Twenty percent of pediatric patients with BA develop ACLF with increased mortality while awaiting LT. Respiratory complications are common in pediatric ACLF and are associated with increased morbidity...

Equity and Disparities in Diagnosis, Management, and Research of Post-Traumatic Headache.

May 16, 2022

There are notable health disparities and inequities in individuals with traumatic brain injury (TBI) and concussion by race, ethnicity, gender, socioeconomic status, and geography. This review will ev...

Prediabetes and insulin resistance in a population of patients with heart failure and reduced or preserved ejection fraction but without diabetes, overweight or hypertension.

May 16, 2022

The relationships between glucose abnormalities, insulin resistance (IR) and heart failure (HF) are unclear, especially regarding to the HF type, i.e., HF with reduced (HFrEF) or preserved (HFpEF) eje...

Clinical Outcomes of Early Vs. Late Tracheostomy in Coronavirus Disease Patients

May 11, 2022

From January 1, 2020, to December 1, 2021, Pubmed, Cochrane Library, Scopus, and Embase were searched to find relevant papers comparing outcomes of COVID-19 patients undergoing early and late tracheos...

Continuous-Wave Doppler Ultrasound Monitor & Echocardiography in Cardiac Postoperative Pediatric Patients

May 11, 2022

In the immediate post-operative course of young, congenital heart repaired patients, non-invasive cardiac output (CO) measurements were critical. In pediatric intensive care units (PICUs), the adoptio...

Glucose TIR in Diabetic & Non-Diabetic Patients and Mortality in Critically Ill Patients

May 11, 2022

For a study, researchers sought to link the proportion of time spent in different blood glucose ranges (TIR) and death in critically sick patients. Adult patients admitted to the ICU for at least 1 da...

Hospital Cost Reductions After Implementing Bedside Percutaneous Ultrasound Gastrostomy (PUG)

May 11, 2022

For a study, researchers sought to determine if introducing bedside percutaneous ultrasound gastrostomy (PUG) would improve efficiency and cost results in ICU patients when compared to traditional gas...

Effect of HFNC vs CPAP Therapy Following Extubation on Liberation From Respiratory Support

May 09, 2022

For a study, researchers sought to compare the time to release from respiratory support using high-flow nasal cannula (HFNC) treatment as the first-line form of noninvasive respiratory support followi...

Hypoxic mesenchymal stem cell-derived extracellular vesicles ameliorate renal fibrosis after ischemia-reperfusion injure by restoring CPT1A mediated fatty acid oxidation.

May 09, 2022

Renal fibrosis is a common pathological process of chronic kidney diseases induced by multiple factors. Hypoxic pretreatment of mesenchymal stem cells can enhance the efficacy of secreted extracellula...

Machine learning derivation of four computable 24-h pediatric sepsis phenotypes to facilitate enrollment in early personalized anti-inflammatory clinical trials.

May 09, 2022

Thrombotic microangiopathy-induced thrombocytopenia-associated multiple organ failure and hyperinflammatory macrophage activation syndrome are important causes of late pediatric sepsis mortality that ...

The Liverpool Heart And bRain Project (L-HARP): Protocol for an Observational Cohort Study of Cardiovascular Risk and Outcomes Following Stroke.

May 09, 2022

Further research is needed to refine risk prediction models for adverse cardiovascular outcomes following stroke in contemporary clinical practice, such as incident atrial fibrillation (AF), recurrent...

Association of immediate reinsertion of new catheters with subsequent mortality among patients with suspected catheter infection: a cohort study.

May 09, 2022

Central venous catheter (CVC) insertion complications are a prevalent and important problem in the intensive care unit (ICU), and source control by immediate catheter removal is considered urgent in p...

Upper Extremity Infections in the Transplant Population.

May 09, 2022

As the duration of lifetime survival after organ transplantation continues to increase, the consequences of long-term immunosuppression, such as opportunistic and rare infections, are a high-risk real...

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