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Critical Care General

Association of trimethylamine-N-oxide levels with risk of cardiovascular disease and mortality among elderly subjects: a systematic review and meta-analysis.

Dec 20, 2021

Trimethylamine-N-Oxide (TMAO) is a microbiome-related metabolite that has been linked to cardiovascular and renal function. This study has reviewed and analyzed the relationship between TMAO and all-c...

Comprehensive Analysis of Bortezomib-Induced Adverse Events Using the Japanese Real-World Database.

Dec 20, 2021

Bortezomib is used as first-line therapy for multiple myeloma. Observational studies based on the FDA Adverse Event Reporting System (FAERS) database analysis and systematic reviews indicate that the ...

Diagnosing capillary leak in critically ill patients: development of an innovative scoring instrument for non-invasive detection.

Dec 20, 2021

The concomitant occurrence of the symptoms intravascular hypovolemia, peripheral edema and hemodynamic instability is typically named Capillary Leak Syndrome (CLS) and often occurs in surgical critica...

The effect of the volemic and cardiac status on brain oxygenation in patients with subarachnoid hemorrhage: a bi-center cohort study.

Dec 20, 2021

Fluid management in patients after subarachnoid hemorrhage (SAH) aims at the optimization of cerebral blood flow and brain oxygenation. In this study, we investigated the effects of hemodynamic mana...

A phenomenological analysis of the experience of taking medication to prevent a further heart attack.

Dec 13, 2021

Following an acute myocardial infarction, patients are prescribed a regime of cardio-protective medication to prevent recurrent cardiovascular events and mortality. Adherence to medication is poor in ...

Electrocardiographic predictors of atrial fibrillation in patients with cryptogenic stroke.

Dec 06, 2021

Empiric anticoagulation is not routinely indicated in patients with cryptogenic stroke without documentation of atrial fibrillation (AF). Therefore, identification of patients at increased risk of AF ...

A cohort study investigating the occurrence of differences in care provided to men and women in an intensive care unit.

Dec 06, 2021

It has been reported that there are differences in the care given within the intensive care unit (ICU) between men and women. The aim of this study is to investigate if any differences still exist bet...

[Design and Application of Intelligent Management System of Artificial Airway Airbag Pressure in Intensive Care].

Dec 06, 2021

In order to solve the problem of continuous monitoring and automatic regulation of patient airbag pressure in intensive care unit, the study designed an intelligent management system of artificial air...

Detecting Myositis as a Cause of Unexplained Dysphagia: Proposal of a Diagnostic Algorithm.

Dec 06, 2021

Idiopathic Inflammatory Myopathy (IIM) can present with dysphagia as leading or only symptom. In such cases, diagnostic evaluation may be difficult, especially if serological and electromyographical f...

The "vestibular neuromatrix": A proposed, expanded vestibular network from graph theory in post-concussive vestibular dysfunction.

Dec 06, 2021

Convergent clinical and neuroimaging evidence suggests that higher vestibular function is subserved by a distributed network including visuospatial, cognitive-affective, proprioceptive, and integrativ...

Results of surgical treatment in chronic anal fissure complicated by abscess or fistula in a retrospective cohort of patients.

Nov 29, 2021

We report the results of the surgical treatment of anal fissures complicated by abscess or fistula and formulate hypotheses about their nature. Among patients operated between 2012 and 2020 for anal f...

Race and sex based disparities in sepsis.

Nov 29, 2021

Studies of sepsis evaluating sex- and race-related disparities in treatment and outcome have been limited by using administrative databases, which may not adequately capture sepsis diagnosis, used lim...

Mind the Difference: Characterizing the Impact of Behavioral Health Disorders on Facial Trauma.

Nov 29, 2021

Patients with psychiatric diagnoses are at greater risk for traumatic injury than the general population. Current literature fails to characterize how premorbid behavioral health disorders (BHDs) comp...

Nuclear Receptors in Myocardial and Cerebral Ischemia-Mechanisms of Action and Therapeutic Strategies.

Nov 29, 2021

Nearly 18 million people died from cardiovascular diseases in 2019, of these 85% were due to heart attack and stroke. The available therapies although efficacious, have narrow therapeutic window and l...

Development of Liposome-Based Immunoassay for the Detection of Cardiac Troponin I.

Nov 29, 2021

Cardiovascular diseases (CVDs) are one of the foremost causes of mortality in intensive care units worldwide. The development of a rapid method to quantify cardiac troponin I (cTnI)-the gold-standard ...

Is early activity resumption after paediatric concussion safe and does it reduce symptom burden at 2 weeks post injury? The Pediatric Concussion Assessment of Rest and Exertion (PedCARE) multicentre randomised clinical trial.

Nov 29, 2021

Investigate whether resuming physical activity (PA) at 72 hours post concussion is safe and reduces symptoms at 2 weeks, compared with resting until asymptomatic.Real-life conditions, multicentre, s...

Traumatic brain injury in the presence of Aβ pathology affects neuronal survival, glial activation and autophagy.

Nov 29, 2021

Traumatic brain injury (TBI) presents a widespread health problem in the elderly population. In addition to the acute injury, epidemiological studies have observed an increased probability and earlier...

Relation between brain natriuretic peptide and delayed cerebral ischemia in patients with aneurysmalsubarachnoid hemorrhage.

Nov 29, 2021

Brain natriuretic peptide (BNP), often used to evaluate degree of heart failure, has been implicated in fluid dysregulation and inflammation in critically-ill patients. Twenty to 30% of patients with ...

A multivariate model for successful publication of intensive care medicine randomized controlled trials in the highest impact factor journals: the SCOTI score.

Nov 29, 2021

Critical care randomized controlled trials (RCTs) are often published in high-impact journals, whether general journals [the New England Journal of Medicine (NEJM), The Lancet, the Journal of the Amer...

In vitro synergistic effect of minocycline combined with antifungals against Cryptococcus neoformans.

Nov 22, 2021

Cryptococcus neoformans infections occur in immunocompromised patients, especially those with HIV infection, chemoradiotherapy after cancer, and organ transplantation. Infection can cause pneumonia an...

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