Nov 08, 2021

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Sestrin2 (SESN2), a highly evolutionarily conserved protein, is critically involved in the ...

Nov 08, 2021

Rehabilitation is key to improving outcomes and quality of life after traumatic brain injury (TBI). However, individuals experiencing homelessness are rarely represented in research that informs evide...

Nov 08, 2021

The effect of severe hypoglycemia on the incidence of heart failure (HF) is unclear.We evaluated the association of severe hypoglycemia with incident HF among individuals with type 2 diabetes.We inclu...

Nov 03, 2021

Early antibiotic therapy has been shown to improve outcomes in sepsis, but patients often present with vague symptoms, making it difficult to recognize the condition early. Treatment delays can occur ...

Nov 01, 2021

Developmental and epileptic encephalopathies (DEE) constitute an expanding group of severely disabling and, most frequently, drug-resistant disorders starting in the first year of life. Among them, th...

Nov 01, 2021

The presence of pharmaceuticals and personal care products (PPCPs) in the environment is primarily the result of discharge of waste, including from onsite wastewater treatment systems (OWTSs) which ar...

Nov 01, 2021

The progress with intensive chemotherapy and supportive care measures has improved survival in patients with newly diagnosed acute myeloid leukemia (AML). Given the recent development of effective low...

Nov 01, 2021

Use of stimulants continues to increase among older adults for a variety of indications. An association between stimulant use and increased risk of cardiovascular (CV) events has been established amon...

Nov 01, 2021

Moderately hypofractionated regimens have emerged as an alternative to stereotactic body radiotherapy for patients with central/ultracentral non-small cell lung cancer (NSCLC) who are medically inoper...

Nov 01, 2021

Cytokines are considered vital mediators of the immune system. Down- or upregulation of these mediators is linked to several inflammatory and pathologic situations. IL-26 is referred to as an identifi...

Nov 01, 2021

Methicillin-resistant Staphylococcus aureus (MRSA) has become the most important pathogen of hospital-acquired (HA) or community-acquired (CA) infections. However, it is unclear of the cytokines respo...

Nov 01, 2021

Our national protocol for traumatic brain injury dictates that hypocoagulated patients with mild trauma and initial tomography scan with no intracranial traumatic changes must be hospitalized for 24 ...

Nov 01, 2021

Mesenchymal stromal cells (MSCs) are widely used in preclinical models of traumatic brain injury (TBI). Results are promising in terms of neurological improvement but are hampered by wide variability ...

Nov 01, 2021

Mechanical circulatory support (MCS) with an implantable left ventricular assist device (LVAD) is an established therapeutic option for advanced heart failure. Most of the currently used LVADs generat...

Oct 25, 2021

Mycoplasma hyopneumoniae is a major pathogen affecting pig herds and vaccination is the most utilized approach, despite providing partial protection. Age at vaccination, the delivery route, and vaccin...

Oct 25, 2021

Obesity is an independent risk factor for worse outcomes in various surgical settings. Whether obesity is a prognostic factor for postoperative morbidity and mortality of colorectal cancer (CRC) is in...

Oct 25, 2021

Sepsis and bloodstream infection are associated with significant morbidity and mortality, and early effective antimicrobial therapy has been demonstrated to improve patient outcomes. Traditional cultu...

Oct 25, 2021

Extracellular vesicles (EVs), including exosomes and microvesicles, are lipid bilayer particles naturally released from the cell. While exosomes are formed as intraluminal vesicles (ILVs) of the multi...

Oct 25, 2021

Current guidelines recommend empiric antifungal therapy in sepsis patients with high risk of invasive Candida infection. However, many different risk factors have been derived from multiple studies. T...

Oct 22, 2021

New research was presented at CHEST 2021, the virtual Annual International Scientific Assembly of the American College of Chest Physicians, from October 17-20. The features below highlight some of the...