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Critical Care General

Prediction of Early (4-week) Mortality in Acute Myeloid Leukemia with Intensive Chemotherapy.

Nov 01, 2021

The progress with intensive chemotherapy and supportive care measures has improved survival in patients with newly diagnosed acute myeloid leukemia (AML). Given the recent development of effective low...

Assessment of Stimulant Use and Cardiovascular Event Risks Among Older Adults.

Nov 01, 2021

Use of stimulants continues to increase among older adults for a variety of indications. An association between stimulant use and increased risk of cardiovascular (CV) events has been established amon...

Role of Modified Frailty Index in Predicting Oncologic Outcomes From Moderately Hypofractionated Radiotherapy for Patients with Stage I-IIB Non-Small Cell Lung Cancer.

Nov 01, 2021

Moderately hypofractionated regimens have emerged as an alternative to stereotactic body radiotherapy for patients with central/ultracentral non-small cell lung cancer (NSCLC) who are medically inoper...

A comprehensive review of IL-26 to pave a new way for a profound understanding of the pathobiology of cancer, inflammatory diseases, and infections.

Nov 01, 2021

Cytokines are considered vital mediators of the immune system. Down- or upregulation of these mediators is linked to several inflammatory and pathologic situations. IL-26 is referred to as an identifi...

Community-acquired methicillin-resistant Staphylococcus aureus provoked cytokine storm causing severe infection on BALB/c mice.

Nov 01, 2021

Methicillin-resistant Staphylococcus aureus (MRSA) has become the most important pathogen of hospital-acquired (HA) or community-acquired (CA) infections. However, it is unclear of the cytokines respo...

HIPTCN: Prospective Observational Study of Hypocoagulated Head Trauma Patients with Normal Admission Computed Tomography Scan.

Nov 01, 2021

Our national protocol for traumatic brain injury dictates that hypocoagulated patients with mild trauma and initial tomography scan with no intracranial traumatic changes must be hospitalized for 24 ...

Systematic review and meta-analysis of preclinical studies testing mesenchymal stromal cells for traumatic brain injury.

Nov 01, 2021

Mesenchymal stromal cells (MSCs) are widely used in preclinical models of traumatic brain injury (TBI). Results are promising in terms of neurological improvement but are hampered by wide variability ...

Effects of Acute Pump Speed Changes on Cerebral Hemodynamics in Patients With an Implantable Continuous-Flow Left Ventricular Assist Devices.

Nov 01, 2021

Mechanical circulatory support (MCS) with an implantable left ventricular assist device (LVAD) is an established therapeutic option for advanced heart failure. Most of the currently used LVADs generat...

Immune B cell responsiveness to single-dose intradermal vaccination against Mycoplasma hyopneumoniae.

Oct 25, 2021

Mycoplasma hyopneumoniae is a major pathogen affecting pig herds and vaccination is the most utilized approach, despite providing partial protection. Age at vaccination, the delivery route, and vaccin...

The impact of obesity on postoperative outcomes in colorectal cancer patients: a retrospective database study.

Oct 25, 2021

Obesity is an independent risk factor for worse outcomes in various surgical settings. Whether obesity is a prognostic factor for postoperative morbidity and mortality of colorectal cancer (CRC) is in...

Culture independent detection systems for bloodstream infection.

Oct 25, 2021

Sepsis and bloodstream infection are associated with significant morbidity and mortality, and early effective antimicrobial therapy has been demonstrated to improve patient outcomes. Traditional cultu...

Extracellular vesicles in cardiovascular disease: Biological functions and therapeutic implications.

Oct 25, 2021

Extracellular vesicles (EVs), including exosomes and microvesicles, are lipid bilayer particles naturally released from the cell. While exosomes are formed as intraluminal vesicles (ILVs) of the multi...

Risk factors for invasive candida infection in critically ill patients - a systematic review and meta-analysis.

Oct 25, 2021

Current guidelines recommend empiric antifungal therapy in sepsis patients with high risk of invasive Candida infection. However, many different risk factors have been derived from multiple studies. T...

Conference Highlights: CHEST 2021

Oct 22, 2021

New research was presented at CHEST 2021, the virtual Annual International Scientific Assembly of the American College of Chest Physicians, from October 17-20. The features below highlight some of the...

The enteroinsular axis during hospitalization in newborn foals.

Oct 18, 2021

The enteroinsular axis (EIA) is an energy regulatory system that modulates insulin secretion through the release of enteroendocrine factors (incretins). Despite the importance of energy homeostasis in...

Effectiveness of Chest CT in Children: CT Findings in Relation to the Clinical Question.

Oct 18, 2021

 To estimate the effectiveness and efficiency of chest CT in children based on the suspected diagnosis in relation to the number of positive, negative, and inconclusive CT results. In this monocen...

METTL3 improves cardiomyocyte proliferation upon myocardial infarction via upregulating miR-17-3p in a DGCR8-dependent manner.

Oct 18, 2021

Myocardial infarction (MI), one of the most severe types of heart attack, exerts a strong negative effect on heart muscle by causing a massive and rapid loss of cardiomyocytes. However, the existing t...

Clinical presentation of simple and combined or syndromic arteriovenous malformations.

Oct 18, 2021

Arteriovenous malformations of the lower extremities (AVM) can present as simple or complex combined or syndromic forms (e.g. Parkes Weber Syndrome). We aimed to characterize the differences in clinic...

Decompressive Craniectomy After Traumatic Brain Injury: Incorporating Patient Preferences into Decision Making.

Oct 18, 2021

Decompressive craniectomy (DC) is highly effective in relieving intracranial hypertension, however patient selection, intracranial pressure threshold, timing, and long-term functional outcomes, are al...

Mega-dose 90Y-Ibritumomab tiuxetan prior to allogeneic transplantation is effective for aggressive large B-cell lymphoma.

Oct 18, 2021

Allogeneic hematopoietic cell transplantation (allo-HCT) can be curative for relapsed or refractory B-cell lymphomas (BCL), though outcomes are worse in aggressive disease and most patients will still...

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