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Critical Care General

Zinc ionophores isolated from Terminalia bellirica fruit rind extract protect against cardiomyocyte hypoxia/reoxygenation injury.

Sep 13, 2021

The study aimed to isolate and characterize zinc ionophores from Terminalia bellirica fruit using a liposome assay and test its utility in H9c2 rat cardiomyoblasts cells subjected to hypoxia/reoxygena...

Cardiac steroid ouabain transcriptionally increases human leukocyte antigen DR expression on monocytes.

Sep 13, 2021

Sepsis is a life-threatening disease characterized by acute multiple organ dysfunction and immunosuppression that is also called as immunoparalysis. Increasing evidence suggests that immunoparalysis l...

Interleukin-35 inhibits lipopolysaccharide-induced endothelial cell activation by downregulating inflammation and apoptosis.

Sep 13, 2021

Inflammation is an essential factor contributing to sepsis-induced endothelial cell (EC) activation. Interleukin-35 (IL-35) is an anti-inflammatory/immunosuppressive cytokine that exerts protective ef...

Amyand's hernia a case report.

Sep 13, 2021

Amyand's hernia (AH) is a form of inguinal hernia which is consider as very rare and this type of hernia occurred up to 1% of all inguinal hernia cases. In this type of inguinal hernia, the content of...

Diverse effects of clarithromycin and proposal of its clinical application for treating COVID-19 as a repurposing drug.

Sep 13, 2021

Outbreak of SARS-CoV-2 has been declared a pandemic, which is a serious threat to human health. The disease was named coronavirus disease 2019 (COVID-19). Until now, several vaccines and a few drugs h...

Esophageal cancer epidemiology, diagnosis, and management in Sudan - A review.

Sep 13, 2021

In Sudan, cancer a common health challenge, is the leading cause of death after malaria and viral pneumonia. The aim of the review is to determine the risk factors associated with esophageal cancer (E...

Guillain Barre Syndrome associated with COVID-19 Infection: A Case Report.

Sep 13, 2021

Coronavirus Disease has become a global pandemic after its emergence at the end of 2019 as a cluster of pneumonia. Apart from respiratory symptoms, neurologic complications are also common, mostly in ...

Sodium-glucose co-transporter2 expression and inflammatory activity in diabetic atherosclerotic plaques: effects of sodium-glucose co-transporter2 inhibitor treatment.

Sep 13, 2021

We evaluated sodium-glucose co-transporter2 (SGLT2) expression and the effect of SGLT2 inhibitor (SGLT2i) therapies on carotid plaques of asymptomatic diabetic and patients without diabetes.Plaques we...

Outcomes of Transfemoral Carotid Artery Stenting and Transcarotid Artery Revascularization for Restenosis after Prior Ipsilateral Carotid Endarterectomy.

Sep 13, 2021

Restenosis after carotid endarterectomy (CEA) poses unique therapeutic challenges, with no specific guidelines on operative approach. Traditionally, transfemoral carotid artery stenting (TfCAS) has be...

Cardiovascular risk associated with allopurinol vs. benzbromarone in patients with gout.

Sep 13, 2021

With the high prevalence of gout and associated cardiovascular (CV) diseases, information on the comparative CV safety of individual urate-lowering drugs becomes increasingly important. However, few s...

Group A Streptococcus puerperal sepsis with invasive neonatal infection: A fatal case.

Sep 13, 2021

Neonatal invasive Group A Streptococcus (GAS) infection is a rare occurrence nowadays. Prior maternal vaginal colonization is an important factor in early neonatal disease. We report a case of invasiv...

Rupture Uterus in a Tertiary Care Centre: A Descriptive Cross-sectional Study.

Sep 13, 2021

Rupture uterus is an obstetric catastrophe with poor maternal and fetal outcome. The objective of the study is to determine the prevalence of rupture uterus in pregnancy.This was a descriptive cross s...

Cesarean Section in a Maternity Unit of a Tertiary Care Center of Nepal: A Descriptive Cross-sectional Study.

Sep 13, 2021

Cesarean section is a common obstetric procedure which is done to reduce complications in high risk pregnancies. The aim of study was to find out the prevalence of cesarean section in a maternity unit...

Mutation of a ubiquitin carboxy terminal hydrolase L1 lipid binding site alleviates cell death, axonal injury, and behavioral deficits after traumatic brain injury in mice.

Sep 13, 2021

Ubiquitin carboxy terminal hydrolase L1 (UCHL1) is a protein highly expressed in neurons that may play important roles in the ubiquitin proteasome pathway in neurons, axonal integrity, and motor funct...

Repeated mild traumatic brain injuries perturb the mitochondrial biogenesis via DNA methylation in the hippocampus of rat.

Sep 13, 2021

Mitochondrial biogenesis in the brain is impaired in various neurological disorders including traumatic brain injury (TBI). The long-lasting effects of TBI may be, in part, attributed to epigenetic me...

The role of neck muscle co-contraction and postural changes in head kinematics after safe head impacts: Investigation of head/neck injury reduction.

Sep 13, 2021

Concerns surrounding concussions from impacts to the head necessitate research to generate new knowledge about ways to prevent them and reduce risk. In this paper, we report the relative temporal char...

Using machine learning to reduce unnecessary rehospitalization of cardiovascular patients in Saudi Arabia.

Sep 13, 2021

Patient readmission is a costly and preventable burden on healthcare systems. The main objective of this study was to develop a machine-learning classification model to identify cardiovascular patient...

Expression levels of serum circulating microRNAs in pediatric patients with ventricular and supraventricular arrhythmias.

Sep 13, 2021

Aberrant expression of various miRNA species has been implicated in numerous cardiac diseases, e.g., heart failure, hypertrophy, conduction disturbances, and arrhythmogenesis. The aim of this study wa...

Mass Critical Care Surge Response during COVID-19: Implementation of Contingency Strategies A Preliminary Report of findings from the Task Force for Mass Critical Care.

Sep 13, 2021

Following the publication of 2014 consensus statement regarding mass critical care during public health emergencies, much has been learned about surge responses and the care of overwhelming numbers of...

Rationing with Respect to Age during a Pandemic: A Comparative Analysis of State Pandemic Preparedness Plans.

Sep 13, 2021

Faced with possible shortages due to COVID-19, many states updated or rapidly developed Crisis Standards of Care (CSCs) and other pandemic preparedness plans (PPPs) for rationing resources, particular...

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