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Critical Care General

Out-of-hospital sepsis recognition by paramedics improves the course of disease and mortality: A single center retrospective study.

Aug 23, 2021

Early recognition of sepsis and a prompt initiation of goal-directed therapy is important for sepsis survival. Little is known about the impact of early recognition of sepsis in the out-of-hospital se...

A rare case of pulmonary nocardiosis comorbid with Sjogren's syndrome.

Aug 23, 2021

Nocardia is an opportunistic pathogen, which occurs in patients with autoimmune diseases and immune dysfunction, and can cause bacteremia and other life-threatening complications. The clinical manifes...

Secondary infections after diagnosis of severe radiation pneumonitis (SRP) among non-small cell lung cancer patients: pathogen distributions, choice of empirical antibiotics and the value of empirical antifungal treatment.

Aug 23, 2021

To assess pathogen distributions and antimicrobial sensitivity characteristics in non-small cell lung cancer (NSCLC) patients diagnosed with severe radiation pneumonitis with secondary infections.Data...

Monocyte human leukocyte antigen-DR but not β-D-glucan may help early diagnosing invasive Candida infection in critically ill patients.

Aug 23, 2021

Precision medicine risk stratification is desperately needed to both avoid systemic antifungals treatment delay and over prescription in the critically ill with risk factors. The aim of the present st...

Retrospective evaluation of the prognostic utility of quick sequential organ failure assessment scores in dogs with surgically treated sepsis (2011-2018): 204 cases.

Aug 23, 2021

To assess the prognostic utility of admission quick Sequential Organ Failure Assessment (qSOFA) scores for in-hospital mortality in a population of dogs with surgically treated sepsis.Retrospective co...

Time course of coagulation and fibrinolytic parameters in pediatric traumatic brain injury.

Aug 23, 2021

Coagulopathy is a well-recognized risk factor for poor outcomes in patients with traumatic brain injury (TBI). Differences in the time courses of coagulation and fibrinolytic parameters between pediat...

Mortality from mental disorders and suicide in male professional American football and soccer players: A meta-analysis.

Aug 23, 2021

To determine the risk of mortality from mental disorders and suicide in professional sports associated with repeated head impacts.A systematic search was performed in PubMed, Web of Science, Scopus, a...

Effect of repetitive transcranial magnetic stimulation on depression and cognition in individuals with traumatic brain injury: a systematic review and meta-analysis.

Aug 23, 2021

Repetitive transcranial magnetic stimulation (rTMS) is an FDA-approved therapy in major depressive disorder. However, its treatment efficacy on depression after traumatic brain injury (TBI) remains in...

Pharmacovigilance analysis of cardiac toxicities associated with targeted therapies for metastatic non-small cell lung carcinoma.

Aug 23, 2021

Targeted therapies have transformed treatment of driver-mutated metastatic non-small cell lung carcinoma (NSCLC). We compared cardiovascular adverse events between and within targeted therapy classes....

Medical and Surgical Management of Left Ventricular Assist Device-Associated Intracranial Hemorrhage.

Aug 23, 2021

Management of left ventricular assist device (LVAD)-associated intracranial hemorrhage (ICH) is complicated by the competing concerns of hematoma expansion and the risk of thrombosis. Strategies inclu...

Lactate is associated with mortality in very old intensive care patients suffering from COVID-19: results from an international observational study of 2860 patients.

Aug 23, 2021

Lactate is an established prognosticator in critical care. However, there still is insufficient evidence about its role in predicting outcome in COVID-19. This is of particular concern in older patien...

Experts Share Facts About Physician Suicide

Aug 20, 2021

By Carolyn Crist Suicide is the only cause of death that is higher among doctors than the general population, according to two Canadian physicians who coauthored an information sheet about physicia...

Protection of the enhanced Nrf2 deacetylation and its downstream transcriptional activity by SIRT1 in myocardial ischemia/reperfusion injury.

Aug 19, 2021

Nrf2, the master gene transcriptor of antioxidant proteins, and SIRT1, the unique Class III histone deacetylase of sirtuins, have been involved in protecting myocardial ischemia/reperfusion (MI/R) inj...

The coronary artery calcification severity on postmortem CT could be a clue for the diagnosis of sudden cardiac death.

Aug 19, 2021

About two-thirds of sudden deaths are sudden cardiac deaths (SCD), and ischemic heart disease (IHD) accounts for 60% of these. Although an autopsy needs to be performed to prove SCD, the forensic auto...

Design, synthesis, and SAR study of novel 4,5-dihydropyrazole-Thiazole derivatives with anti-inflammatory activities for the treatment of sepsis.

Aug 19, 2021

Systemic inflammatory response syndrome is a major feature of sepsis which is one of the major causes of death worldwide. It has been reported that 3,5-diaryl-4,5-dihydropyrazole and thiazole derivati...

Kidney allograft biopsy findings after COVID-19.

Aug 19, 2021

COVID-19 has been associated with acute kidney injury and published reports of native kidney biopsies have reported diverse pathologies. Case series directed specifically to kidney allograft biopsy fi...

Clinical Impact of Surgical Lung Biopsy for Interstitial Lung Disease in a Reference Center.

Aug 19, 2021

Diagnosis of interstitial lung disease is based on the analysis of clinical, biological, radiological and pathological findings during a multidisciplinary discussion (MDD). When a definitive diagnosis...

Systemic Inflammation after Uniport, Multiport, or Hybrid VATS Lobectomy for Lung Cancer.

Aug 19, 2021

 Different video-assisted thoracic surgery (VATS) approaches can be adopted to perform lobectomy for non-small cell lung cancer. Given the hypothetical link existing between postoperative inflammati...

1-Year Results From a Prospective Experience on CAS Using the CGuard Stent System: The IRONGUARD 2 Study.

Aug 19, 2021

The aim of this study was to evaluate the 1-year safety and efficacy of a dual-layered stent (DLS) for carotid artery stenting (CAS) in a multicenter registry.DLS have been proved to be safe and effic...

Pre-Diagnosis Exercise and Cardiovascular Events in Primary Breast Cancer: Women's Health Initiative.

Aug 19, 2021

The purpose of this study was to investigate whether pre-diagnosis exercise reduces the risk of subsequent cardiovascular events (CVEs) in women with primary breast cancer.Cardiovascular disease (CVD)...

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