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Critical Care General

Derivation of a clinical score for prediction of recurrence following evacuation of chronic subdural haematoma: A retrospective cohort study at a national referral centre.

Aug 05, 2021

Chronic subdural haematoma (cSDH) is a common pathology and recurrence is a common complication, which may be predicted by certain radiological and patient factors. Empiric radiological surveillance h...

Aberrant modulation of brain activity underlies impaired working memory following traumatic brain injury.

Aug 05, 2021

Impaired working memory is a common and disabling consequence of traumatic brain injury (TBI) that is caused by aberrant brain processing. However, little is known about the extent to which deficits a...

Integrated multiomics analysis identifies molecular landscape perturbations during hyperammonemia in skeletal muscle and myotubes.

Aug 05, 2021

Ammonia is a cytotoxic molecule generated during normal cellular functions. Dysregulated ammonia metabolism, which is evident in many chronic diseases such as liver cirrhosis, heart failure and chroni...

Adults at risk of pneumococcal disease in France.

Aug 05, 2021

Immunocompromised patients and those with certain underlying medical conditions are at risk of pneumococcal disease, but in France their vaccine coverage is largely unknown. We aimed to assess the num...

Trends, Predictors and Outcomes of Ischemic Stroke Among Patients Hospitalized with Takotsubo Cardiomyopathy.

Aug 02, 2021

This study assessed the temporal trends in the incidence of ischemic stroke among patients hospitalized with takotsubo cardiomyopathy (TCM) stratified by the subtypes of ischemic stroke (cardioembolic...

Dystrophin and metalloproteinase 9 in myocardial ischemia: A post-mortem immunohistochemical study.

Aug 02, 2021

The presented study evaluated the expression of dystrophin and MMP-9 in cases of sudden cardiac death (SCD) due to coronary atherosclerotic disease (CAD) in order to analyze the characteristics and th...

Feasibility study evaluating a veterinary point-of-care urine culture system for diagnosing septic peritonitis.

Aug 02, 2021

To evaluate the use of a veterinary point-of-care urine culture system (POCUCS) for the diagnosis of septic peritonitis.Prospective feasibility study performed between August 2017 and April 2018.Priva...

Sialic acid-conjugate modified doxorubicin nanoplatform for treating neutrophil-related inflammation.

Aug 02, 2021

Neutrophils, the most abundant leukocytes in human peripheral blood, are important effector cells that mediate the inflammatory response. During neutrophil dysfunction, excessive activation and uncont...

Systematic beach monitoring as a health assessment tool: cetacean morbillivirus under non-epizootic circumstances in stranded dolphins.

Aug 02, 2021

Cetacean morbillivirus (CeMV) was identified as the etiologic agent of several epizootic episodes worldwide. Most of these studies are based on unusual mortality events or identification of new viral ...

Bilateral lung transplantation during pregnancy after ECMO for influenza-A caused ARDS.

Aug 02, 2021

Pregnant women with influenza-A have an increased risk of developing acute respiratory distress syndrome (ARDS). Extracorporeal membrane oxygenation (ECMO) can be used as salvage therapy, with lung tr...

Impact of a computerized physician order entry (CPOE)-based antibiotic stewardship intervention on the treatment duration for pneumonia and COPD exacerbations.

Aug 02, 2021

In hospitalized patients, the duration of antibiotic therapy for uncomplicated pneumonia is often longer than recommended in clinical guidelines. Consequences include increased risk of Clostridioides ...

Intraoperative hypotension and its organ-related consequences in hypertensive subjects undergoing abdominal surgery: a cohort study.

Aug 02, 2021

. Intraoperative hypotension is associated with organ hypoperfusion, which is deleterious to vital organs. Little is known about the prevalence and consequences of intraoperative hypotension in subjec...

Rates, Predictors, and Impact of Smoking Cessation after Stroke or Transient Ischemic Attack: A Systematic Review and Meta-Analysis.

Aug 02, 2021

Smoking cessation after a first cardiovascular event reduces the risk of recurrent vascular events and mortality. This systematic review and meta-analysis aimed to summarize data on the rates, predict...

Extreme temperature exposure and acute myocardial infarction: Elevated risk within hours?

Aug 02, 2021

Day-to-day change in ambient temperature is associated with acute myocardial infarction (AMI) attacks, but evidence is scarce about the effects of extreme temperatures on the risk of AMI within hours ...

Locally developed external fixators as definitive treatment of open tibia diaphyseal fractures: a clinical prospective study conducted in Ivory Coast.

Aug 02, 2021

This study sought to evaluate the effectiveness of locally developed external fixators (LDEF) as definitive treatment for open tibia diaphyseal fractures (OTDF) in Ivory Coast.Gustilo I, II, and IIIA ...

Pancreatic damage in COVID-19: Why? How?

Aug 02, 2021

We aimed to evaluate the elevation of amylase and lipase enzymes in coronavirus disease 2019 (COVID-19) patients and their relationship with the severity of COVID-19.In this study, 1378 patients with ...

High presepsin concentrations in bile and its marked elevation in biliary tract diseases: A retrospective analysis.

Aug 02, 2021

Presepsin is a diagnostic and prognostic biomarker of both bacterial infection and sepsis; however, elevated presepsin levels have also been observed without sepsis. We conducted several analyses to e...

Development of prognostic models for Health-Related Quality of Life following traumatic brain injury.

Aug 02, 2021

Traumatic brain injury (TBI) is a leading cause of impairments affecting Health-Related Quality of Life (HRQoL). We aimed to identify predictors of and develop prognostic models for HRQoL following TB...

Brain Temperature Influences Intracranial Pressure and Cerebral Perfusion Pressure After Traumatic Brain Injury: A CENTER-TBI Study.

Aug 02, 2021

After traumatic brain injury (TBI), fever is frequent. Brain temperature (BT), which is directly linked to body temperature, may influence brain physiology. Increased body and/or BT may cause secondar...

Optimal Targets of the First 24-h Partial Pressure of Carbon Dioxide in Patients with Cerebral Injury: Data from the MIMIC-III and IV Database.

Aug 02, 2021

It is generally believed that hypercapnia and hypocapnia will cause secondary injury to patients with craniocerebral diseases, but a small number of studies have shown that they may have potential ben...

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