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Critical Care General

Alpha-ketoglutarate ameliorates pressure overload-induced chronic cardiac dysfunction in mice.

Aug 09, 2021

Increasing evidence indicates the involvement of myocardial oxidative injury and mitochondrial dysfunction in the pathophysiology of heart failure (HF). Alpha-ketoglutarate (AKG) is an intermediate me...

Astrocytes constitute the major TNF-α-producing cell population in the infarct cortex in dMCAO rats receiving intravenous MSC infusion.

Aug 05, 2021

Recent studies report that inhibiting TNF-α might be a novel therapeutic strategy for managing brain ischemia. Our previous study reported that mesenchymal stem cell (MSC) transplantation could suppr...

The protective effect of allicin on myocardial ischemia-reperfusion by inhibition of Ca overload-induced cardiomyocyte apoptosis via the PI3K/GRK2/PLC-γ/IP3R signaling pathway.

Aug 05, 2021

To investigate the protective effect and mechanism of allicin on myocardial ischemia-reperfusion (MI/R) injury.We investigated the mechanisms by which allicin attenuated the MI/R injury by focusing on...

Prescription Drug Overdose, Depression, and Other Mental Disorders in the Context of Kidney Disease.

Aug 05, 2021

Clinical Background: Mental disorders, especially depression, are associated with several comorbidities in the kidneys. Depression is the psychiatric disorder that mostly affects individuals with chro...

HSPA12A improves endothelial integrity to attenuate lung injury during endotoxemia through activating ERKs and Akt-dependent signaling.

Aug 05, 2021

Acute lung injury (ALI) is a critical manifestation of sepsis/septic shock. Disruption of endothelial barrier function is critical for ALI pathogenesis; however, the regulation of endothelial barrier ...

Sepsis and Kidney Injury.

Aug 05, 2021

Clinical Background: Clinical infections and its most severe forms sepsis and septic shock are commonly associated with changes in kidney function. This acute kidney injury (AKI) is associated with in...

Levels of pneumococcal conjugate vaccine coverage and indirect protection against invasive pneumococcal disease and pneumonia hospitalisations in Australia: An observational study.

Aug 05, 2021

There is limited empiric evidence on the coverage of pneumococcal conjugate vaccines (PCVs) required to generate substantial indirect protection. We investigate the association between population PCV ...

Pulmonary parenchymal changes in COVID-19 survivors.

Aug 05, 2021

As the COVID-19 pandemic moves into the survivorship phase, questions regarding long-term lung damage remain unanswered. Previous histopathological studies are limited to autopsy reports. We studied l...

COVID-19 and the Kidney: Should Nephrologists Care about COVID-19 rather than Maintaining Their Focus on Renal Patients?

Aug 05, 2021

Clinical Background: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly spread globally from late 2019, reaching pandemic proportions. Epidemiology: The related disease, CO...

Nurse-based secondary preventive follow-up by telephone reduced recurrence of cardiovascular events: a randomised controlled trial.

Aug 05, 2021

Enhanced follow-up is needed to improve the results of secondary preventive care in patients with established cardiovascular disease. We examined the effect of long-term, nurse-based, secondary preven...

Epidemiology of clinically suspected and laboratory-confirmed bloodstream infections at a South African neonatal unit.

Aug 05, 2021

Data from Africa reporting the epidemiology of infection in hospitalised neonates are limited.A prospective study with convenience sampling was conducted to characterise neonates investigated with blo...

Neonatal multidrug-resistant bacterial meningitis: a 29-year study from a tertiary hospital in Thailand.

Aug 05, 2021

This study aimed to compare the risks and case fatality rate (CFR) between neonatal multidrug-resistant (MDR) and non-MDR meningitis.a secondary analysis of a case-control studies in a Thai neonatal i...

C-Reactive Protein, Interleukin-6, and Procalcitonin in Diagnosis of Late-Onset Bloodstream Infection in Very Preterm Infants.

Aug 05, 2021

Late-onset bloodstream infection (LOBSI) is common in very preterm infants. Early and accurate diagnosis is crucial for prognosis and outcome. We aimed to analyze the accuracy of routinely used inflam...

Neuroprotective effects of low-intensity transcranial ultrasound stimulation combined with Baicalin intervention on traumatic brain injury in animals.

Aug 05, 2021

Low-intensity transcranial ultrasound stimulation (LITUS) can improve the inflammatory reaction after traumatic brain injury (TBI), and Baicalin also has a good protective effect on TBI. The purpose o...

Derivation of a clinical score for prediction of recurrence following evacuation of chronic subdural haematoma: A retrospective cohort study at a national referral centre.

Aug 05, 2021

Chronic subdural haematoma (cSDH) is a common pathology and recurrence is a common complication, which may be predicted by certain radiological and patient factors. Empiric radiological surveillance h...

Aberrant modulation of brain activity underlies impaired working memory following traumatic brain injury.

Aug 05, 2021

Impaired working memory is a common and disabling consequence of traumatic brain injury (TBI) that is caused by aberrant brain processing. However, little is known about the extent to which deficits a...

Integrated multiomics analysis identifies molecular landscape perturbations during hyperammonemia in skeletal muscle and myotubes.

Aug 05, 2021

Ammonia is a cytotoxic molecule generated during normal cellular functions. Dysregulated ammonia metabolism, which is evident in many chronic diseases such as liver cirrhosis, heart failure and chroni...

Adults at risk of pneumococcal disease in France.

Aug 05, 2021

Immunocompromised patients and those with certain underlying medical conditions are at risk of pneumococcal disease, but in France their vaccine coverage is largely unknown. We aimed to assess the num...

Trends, Predictors and Outcomes of Ischemic Stroke Among Patients Hospitalized with Takotsubo Cardiomyopathy.

Aug 02, 2021

This study assessed the temporal trends in the incidence of ischemic stroke among patients hospitalized with takotsubo cardiomyopathy (TCM) stratified by the subtypes of ischemic stroke (cardioembolic...

Dystrophin and metalloproteinase 9 in myocardial ischemia: A post-mortem immunohistochemical study.

Aug 02, 2021

The presented study evaluated the expression of dystrophin and MMP-9 in cases of sudden cardiac death (SCD) due to coronary atherosclerotic disease (CAD) in order to analyze the characteristics and th...

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