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Critical Care General

Updated Guidance on Managing C. difficile Infection

Jul 26, 2021

“While the burden of diarrhea and colitis due to C. difficile infection (CDI) has decreased slightly in the United States, it is still responsible for nearly 500,000 cases, and 70,000 recurrent case...

Endovascular aortic repair for abdominal aortic injury complicated with bowel injury due to blunt abdominal trauma: A case report.

Jul 26, 2021

Blunt abdominal aortic injury (BAAI) resulting from blunt abdominal trauma is rare; therefore, there are no standard guidelines for its treatment. Herein, we report the successful treatment of BAAI vi...

Direct in vivo reprogramming with non-viral sequential targeting nanoparticles promotes cardiac regeneration.

Jul 26, 2021

microRNA-mediated direct cardiac reprogramming, directly converts fibroblasts into induced cardiomyocyte-like cells (iCMs), which holds great promise in cardiac regeneration therapy. However, effectiv...

Hematopoietic Stem Cell Transplantation For Patients With Autosomal Recessive Complete Interferon Gamma Receptor 2 Deficiency: Experience In Oman.

Jul 26, 2021

Autosomal recessive complete interferon- gamma receptor-2 (IFN-γR2) deficiency is a rare potentially fatal primary immune deficiency that predisposes to disseminated mycobacterial disease.Hematopoiet...

Aiming for a bull's-eye: Targeting antifungals to fungi with dectin-decorated liposomes.

Jul 26, 2021

Globally, there are several million individuals with life-threatening invasive fungal diseases such as candidiasis, aspergillosis, cryptococcosis, Pneumocystis pneumonia (PCP), and mucormycosis. The m...

Multimorbidity of chronic diseases of lifestyle among South African adults.

Jul 26, 2021

the prevalence of non-communicable and chronic diseases has been on the increase globally and has been a major factor responsible for high morbidity and mortality. Multimorbidity of the chronic diseas...

Complement dysregulation is associated with severe COVID-19 illness.

Jul 26, 2021

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) may manifest as thrombosis, stroke, renal failure, myocardial infarction, and thrombocytopenia, reminiscent of other complement-mediated di...

Association between antenatal corticosteroid use and perinatal mortality among preterm births in hospitals in Tanzania.

Jul 26, 2021

The primary aims of this study were to investigate if exposure to antenatal corticosteroids (ACS) was associated with lower rates of perinatal mortality (primary outcome) and other adverse perinatal o...

Mortality, Sepsis, and Organ Failure in Hospitalized Patients with Cirrhosis Vary by Type of Infection.

Jul 26, 2021

Infection is associated with substantial morbidity and mortality in cirrhosis, but presumably not all infections carry the same risk of mortality. We compared outcomes of different sites of infection ...

Covid-19 and Risk of Venous Thromboembolism in Ethnically Diverse Populations.

Jul 26, 2021

Limited existing data suggest the novel coronavirus disease 2019 (Covid-19) may increase risk for venous thromboembolism (VTE) but information from large, ethnically diverse populations with appropria...

First-Line Health Care Providers' Reported Knowledge of and Referrals to Speech-Language Pathologists for Clients With Mild Traumatic Brain Injury.

Jul 26, 2021

Purpose People with mild traumatic brain injury (mTBI) may experience deficits in cognition or communication that go unnoticed by first-line health care providers (FHPs). Speech-language pathologists ...

Orientation of Neurites Influences Severity of Mechanically-Induced Tau Pathology.

Jul 26, 2021

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repeated traumatic brain injury (TBI). CTE is a tauopathy, in which cognitive decline is accompanied by the accumu...

Astrocyte-derived CCL7 promotes microglia-mediated inflammation following traumatic brain injury.

Jul 26, 2021

Microglia are immune cells of the central nervous system that mediate neuroinflammation. It is widely known that microglia-mediated inflammation in the brain contribute to the widespread tissue damage...

Testosterone therapy and cardiovascular diseases.

Jul 26, 2021

Since it was first synthesised in 1935, testosterone (T) has been viewed as the mythical Fountain of Youth, promising rejuvenation, restoring sexual appetites, growing stronger muscles, and quicker th...

Increased Estimated Fat-free and Fat Mass Associated with Improved Clinical Outcome in Heart Failure.

Jul 26, 2021

Increased weight measured by body mass index is associated with better clinical outcomes in heart failure (HF). The effect of specific components of body mass on outcome is limited. We evaluated the i...

Partial Flap Loss in Gender Affirming Phalloplasty.

Jul 22, 2021

 Flaps used in phalloplasty are larger than described for other indications, with a design that is tubularized up to two times. While the incidence of partial flap loss (PFL) is well described, curr...

The effect of influenza and pneumococcal vaccination in the elderly on health service utilisation and costs: a claims data-based cohort study.

Jul 22, 2021

To date, cost-effectiveness of influenza and pneumococcal vaccinations was assumed in several health economic modelling studies, but confirmation by real-world data is sparse. The aim of this study is...

Automatic continuous EEG signal analysis for diagnosis of delirium in patients with sepsis.

Jul 22, 2021

In critical care, continuous EEG (cEEG) monitoring is useful for delirium diagnosis. Although visual cEEG analysis is most commonly used, automatic cEEG analysis has shown promising results in small s...

Clinical Features in a Large Cohort of Patients With 22q11.2 Deletion Syndrome.

Jul 22, 2021

To evaluate various clinical aspects, specifically regarding immune status, in a large cohort of patients with DGS.Data were collected of 98 patients with DGS treated at a tertiary medical center. Thi...

Genomic Insights into a Complete Deletion of the mgrB Locus in Colistin-Resistant Klebsiella pneumoniae ST2268 Isolated from a Human Infection.

Jul 22, 2021

The emergence of colistin-resistant Klebsiella pneumoniae (CoRKp) is a serious public health issue because colistin is the last line of defense against infections caused by multidrug-resistant Gram-ne...

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