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Critical Care General

Complement dysregulation is associated with severe COVID-19 illness.

Jul 26, 2021

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) may manifest as thrombosis, stroke, renal failure, myocardial infarction, and thrombocytopenia, reminiscent of other complement-mediated di...

Association between antenatal corticosteroid use and perinatal mortality among preterm births in hospitals in Tanzania.

Jul 26, 2021

The primary aims of this study were to investigate if exposure to antenatal corticosteroids (ACS) was associated with lower rates of perinatal mortality (primary outcome) and other adverse perinatal o...

Mortality, Sepsis, and Organ Failure in Hospitalized Patients with Cirrhosis Vary by Type of Infection.

Jul 26, 2021

Infection is associated with substantial morbidity and mortality in cirrhosis, but presumably not all infections carry the same risk of mortality. We compared outcomes of different sites of infection ...

Covid-19 and Risk of Venous Thromboembolism in Ethnically Diverse Populations.

Jul 26, 2021

Limited existing data suggest the novel coronavirus disease 2019 (Covid-19) may increase risk for venous thromboembolism (VTE) but information from large, ethnically diverse populations with appropria...

First-Line Health Care Providers' Reported Knowledge of and Referrals to Speech-Language Pathologists for Clients With Mild Traumatic Brain Injury.

Jul 26, 2021

Purpose People with mild traumatic brain injury (mTBI) may experience deficits in cognition or communication that go unnoticed by first-line health care providers (FHPs). Speech-language pathologists ...

Orientation of Neurites Influences Severity of Mechanically-Induced Tau Pathology.

Jul 26, 2021

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repeated traumatic brain injury (TBI). CTE is a tauopathy, in which cognitive decline is accompanied by the accumu...

Astrocyte-derived CCL7 promotes microglia-mediated inflammation following traumatic brain injury.

Jul 26, 2021

Microglia are immune cells of the central nervous system that mediate neuroinflammation. It is widely known that microglia-mediated inflammation in the brain contribute to the widespread tissue damage...

Testosterone therapy and cardiovascular diseases.

Jul 26, 2021

Since it was first synthesised in 1935, testosterone (T) has been viewed as the mythical Fountain of Youth, promising rejuvenation, restoring sexual appetites, growing stronger muscles, and quicker th...

Increased Estimated Fat-free and Fat Mass Associated with Improved Clinical Outcome in Heart Failure.

Jul 26, 2021

Increased weight measured by body mass index is associated with better clinical outcomes in heart failure (HF). The effect of specific components of body mass on outcome is limited. We evaluated the i...

Partial Flap Loss in Gender Affirming Phalloplasty.

Jul 22, 2021

 Flaps used in phalloplasty are larger than described for other indications, with a design that is tubularized up to two times. While the incidence of partial flap loss (PFL) is well described, curr...

The effect of influenza and pneumococcal vaccination in the elderly on health service utilisation and costs: a claims data-based cohort study.

Jul 22, 2021

To date, cost-effectiveness of influenza and pneumococcal vaccinations was assumed in several health economic modelling studies, but confirmation by real-world data is sparse. The aim of this study is...

Automatic continuous EEG signal analysis for diagnosis of delirium in patients with sepsis.

Jul 22, 2021

In critical care, continuous EEG (cEEG) monitoring is useful for delirium diagnosis. Although visual cEEG analysis is most commonly used, automatic cEEG analysis has shown promising results in small s...

Clinical Features in a Large Cohort of Patients With 22q11.2 Deletion Syndrome.

Jul 22, 2021

To evaluate various clinical aspects, specifically regarding immune status, in a large cohort of patients with DGS.Data were collected of 98 patients with DGS treated at a tertiary medical center. Thi...

Genomic Insights into a Complete Deletion of the mgrB Locus in Colistin-Resistant Klebsiella pneumoniae ST2268 Isolated from a Human Infection.

Jul 22, 2021

The emergence of colistin-resistant Klebsiella pneumoniae (CoRKp) is a serious public health issue because colistin is the last line of defense against infections caused by multidrug-resistant Gram-ne...

Characteristics and Outcomes of Children With Necrotizing Pneumonia.

Jul 22, 2021

In this study, we describe the characteristics and outcomes of pediatric necrotizing pneumonia in the United States.A retrospective analysis of the Healthcare Cost and Utilization Project 2016 Kids In...

Association of Iso-Osmolar vs Low-Osmolar Contrast Media With Major Adverse Renal or Cardiovascular Events in Patients at High Risk for Acute Kidney Injury Undergoing Endovascular Abdominal Aortic Aneurysm Repair.

Jul 22, 2021

The purpose of this analysis was to examine the association of iso-osmolar contrast media (IOCM) vs low-osmolar contrast media (LOCM) with major adverse renal or cardiovascular events (MARCE) in patie...

Outcomes of Carotid Revascularization in the Treatment of Restenosis After Prior Carotid Endarterectomy.

Jul 22, 2021

Restenosis after carotid endarterectomy (CEA) is associated with an increased risk of ipsilateral stroke. The optimal procedural modality for this indication has yet to be determined. Here, we evaluat...

Traces of SARS-CoV-2 RNA in Peripheral Blood Cells of Patients with COVID-19.

Jul 22, 2021

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the third virus that caused coronavirus-related outbreaks over the past 20 years. The outbreak was first reported in December 2019 i...

Albumin Infusion in Critically Ill COVID-19 Patients: Hemodilution and Anticoagulation.

Jul 22, 2021

Hypercoagulation is one of the major risk factors for ICU treatment, mechanical ventilation, and death in critically ill patients infected with SARS-CoV-2. At the same time, hypoalbuminemia is one ris...

Aptamer-based biosensors for the diagnosis of sepsis.

Jul 22, 2021

Sepsis, the syndrome of infection complicated by acute organ dysfunction, is a serious and growing global problem, which not only leads to enormous economic losses but also becomes one of the leading ...

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