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Critical Care General

Exosomal microRNA-16-5p from adipose mesenchymal stem cells promotes TLR4-mediated M2 macrophage polarization in septic lung injury.

Jul 01, 2021

Reports on septic lung injury have implicated the protective effects of adipose mesenchymal stem cells-derived Exos (ADSCs-Exos). At present, we tried to explain the mechanism of ADSCs-Exos-loaded mic...

Impact of COVID-19 on a brain damage unit.

Jul 01, 2021

To report on the impact of COVID-19 on a brain damage unit.We reviewed the records of all patients admitted to our brain damage unit. The study included all the significant clinical events from the fi...

COVID-19 and Candida duobushaemulonii superinfection: A case report.

Jul 01, 2021

Critically ill COVID-19 patients are at high risk for nosocomial bacterial and fungal infections due to several predisposing factors such as intensive care unit stay, mechanical ventilation, and broad...

Cardiac phospholipidome is altered during ischemia and reperfusion in an ex vivo rat model.

Jul 01, 2021

Acute myocardial infarction (AMI) is the leading cause of death, morbidity, and health costs worldwide. In AMI, a sudden blockage of blood flow causes myocardial ischemia and cell death. Reperfusion a...

Acute myocardial infarction on YouTube - Is it all fake news?

Jul 01, 2021

The Internet is a fundamental aspect of health information. However, the absence of quality control encourages misinformation. We aim to assess the relevance and quality of acute myocardial infarction...

Bacterial infections in people who inject psychoactive substances: An observational study in a French university hospital.

Jul 01, 2021

To describe bacterial infections in injection drug users (IDUs) hospitalized at Montpellier University Hospital, France, and to identify factors that might influence the development of local or system...

[Utility of C-reactive protein in early neonatal sepsis].

Jul 01, 2021

The low sensitivity and specificity of diagnostic aids and the low isolation in cultures make it difficult to recognize early-onset bacterial sepsis in neonates.Determine the diagnostic validity of C ...

Antibiotic Timing and Progression to Septic Shock Among Emergency Department Patients with Suspected Infection.

Jul 01, 2021

Recent medical society opinions have questioned the use of early antimicrobials in patients with sepsis, but without septic shock.Is time from Emergency Department (ED) presentation to administration ...

A phase transition enhances the catalytic activity of SARM1, an NAD glycohydrolase involved in neurodegeneration.

Jul 01, 2021

Sterile alpha and toll/interleukin receptor (TIR) motif-containing protein 1 (SARM1) is a neuronally expressed NAD glycohydrolase whose activity is increased in response to stress. NAD depletion trigg...

Incidence of sports-related concussion in elite para athletes - a 52-week prospective study.

Jul 01, 2021

: To assess the 52-week incidence proportion and incidence rate of sports-related concussion (SRC) among elite Para athletes, and to analyze the injury mechanisms. In total, 70 male and 37 female Swed...

Diagnosis, Management and Return to Sport of a 16-year-old Patient with a Chiari I Malformation: A Case Report and Literature Review.

Jul 01, 2021

This CASE report presents a 16-year-old female volleyball, basketball and track & field athlete who was diagnosed with a Chiari I Malformation following a concussion. Surgical decompression was re...

Sympathoinhibitory effect of sacubitril-valsartan in heart failure with reduced ejection fraction: A pilot study.

Jul 01, 2021

Chronic sympathetic nervous system (SNS) overactivity, characteristic of heart failure (HF) with reduced ejection fraction (HFrEF), is associated with poor prognosis and contributes to increased morta...

Self-management on heart failure: A meta-analysis.

Jul 01, 2021

Heart failure (HF) is a severe public health problem all over the World. Self-management is an effective method to progress self-care ability. However, the role of self-management in heart failure has...

SICQ coping and the health-related quality of life and recovery of critically ill ICU patients: A prospective cohort study.

Jul 01, 2021

The coping styles of the Sickness Insight in Coping Questionnaire (SICQ; positivism, redefinition, toughness, fighting spirit, non-acceptance) may affect the health and recovery of hospitalized critic...

Trillium tschonoskii rhizomes' saponins induces oligodendrogenesis and axonal reorganization for ischemic stroke recovery in rats.

Jun 28, 2021

Trillium tschonoskii Maxim. is one of traditional Chinese medical herbs that has been utilized to treat brain damages and cephalalgia. The neuroprotective effect of total saponins from Trillium tschon...

TRP channels in COVID-19 disease: Potential targets for prevention and treatment.

Jun 28, 2021

Coronavirus disease 2019 [COVID-19] is a global health threat caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV2] that requires two proteins for entry: angiotensin-converting enzyme ...

A Novel 29-Messenger RNA Host-Response Assay From Whole Blood Accurately Identifies Bacterial and Viral Infections in Patients Presenting to the Emergency Department With Suspected Infections: A Prospective Observational Study.

Jun 28, 2021

The rapid diagnosis of acute infections and sepsis remains a serious challenge. As a result of limitations in current diagnostics, guidelines recommend early antimicrobials for suspected sepsis patien...

Evaluation of leukopenia during sepsis as a marker of sepsis-defining organ dysfunction.

Jun 28, 2021

Although both leukocytosis and leukopenia have been considered Systemic Inflammatory Response Syndrome criteria, leukopenia is not generally considered a normal response to infection. We sought to eva...

The combination of CipA and PBP-7/8 proteins contribute to the survival of C57BL/6 mice from sepsis of Acinetobacter baumannii.

Jun 28, 2021

Due to the emergence of multi-drug resistant Acinetobacter baumannii strains, there is an urgent need to develop several new strategies to control this bacterium. In this context, vaccination may be t...

Heterogeneity in blood biomarker trajectories after mild TBI revealed by unsupervised learning.

Jun 28, 2021

Concussions, also known as mild traumatic brain injury (mTBI), are a growing health challenge. Approximately four million concussions are diagnosed annually in the United States. Concussion is a heter...

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