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Critical Care General

HIF-1α aggravated traumatic brain injury by NLRP3 inflammasome-mediated pyroptosis and activation of microglia.

Jun 28, 2021

Hypoxia inducible factor 1 alpha (HIF-1α) is involved in regulating the biological functions of neuronal death after traumatic brain injury (TBI), and attaches importance in the inflammatory response...

Traumatic brain injury related paediatric mortality and morbidity in low- and middle-income countries: a systematic review.

Jun 28, 2021

The burden of paediatric traumatic brain injury (pTBI) in low-and-middle-income countries (LMICs) is unknown. To fill this gap, we conducted a review that aimed to characterise the causes of pTBI in L...

ADL-dependent older adults were identified in medico-administrative databases.

Jun 28, 2021

. We aimed to develop an algorithm for the identification of basic Activities of Daily Living (ADL)-dependency in health insurance databases.. We used the AMI (Aging Multidisciplinary Investigation) p...

The Impact of Depression on Outcomes in Patients with Heart Failure and Reduced Ejection Fraction Treated in the GUIDE-IT Trial.

Jun 28, 2021

It remains unclear why depression is associated with adverse outcomes in heart failure (HF) patients. We examine the relationship between depression and clinical outcomes among patients with HF and re...

IL-38 as an early predictor of the ischemic stroke prognosis.

Jun 24, 2021

Ischemic stroke is caused by a sudden neurological defect following a vascular occlusion and elicits a local and systemic inflammation in brain tissue. Interleukin-38 is an anti-inflammatory cytokine ...

Outcomes for Infants Born in Perinatal Centers Performing Fewer Surgical Ligations for Patent Ductus Arteriosus: A Swiss Population-Based Study.

Jun 24, 2021

To assess patent ductus arteriosus (PDA) treatment variation between Swiss perinatal centers and to determine its effect on outcome in a population-based setting.Retrospective cohort study of infants ...

A case report on non-specific synovitis of the knee due to septic foreign body in the Hoffa fat pad causing diagnostic dilemma.

Jun 24, 2021

Recurrent chronic synovitis due to foreign body is a rare entity and it may progress into chronic septic arthritis. Chronic recurrent synovitis or septic arthritis may leave permanent damage to the ar...

Maintenance treatment in relapsed canine lymphoma after a short L-CHOP protocol.

Jun 24, 2021

A number of different rescue protocols for relapsed canine multicentric large-cell lymphoma have been described. The aim of this pilot study was to evaluate the efficacy of a maintenance treatment in ...

The Risk Factors of Psychological Responses for Chinese University Students on COVID-19 Outbreak: A Cross-Sectional Online Survey Study.

Jun 24, 2021

The novel coronavirus pneumonia (COVID-19) is a highly contagious and highly pathogenic disease caused by a novel coronavirus(SARS-CoV-2)and has become a pandemic. As a vulnerable population, univ...

Association of rare predicted loss-of-function variants of influenza-related type I IFN genes with critical COVID-19 pneumonia. Reply.

Jun 24, 2021

The authors reply: We appreciate the interest of Dr. Zhang and colleagues in our manuscript. The main difference between our publication and that of Zhang et al. (1), was that we assessed all rare pre...

A New Parameter For Predict The Clinical Outcome of Patients With Covid-19 Pneumonia: The Direct/Total Bilirubin Ratio.

Jun 24, 2021

An urgent need to define clinical and laboratory parameters to predict progression to the severe and lethal forms of Coronavirus Disease 2019 (COVID 19). To investigate the direct/total bilirubin rati...

Contemporary Results of Carotid Artery Stenting Using Low-Profile Dual-Metal Layer Nitinol Micromesh Stents in Relation to Single-Layer Carotid Stents.

Jun 24, 2021

To evaluate patients characteristics, procedural details, perioperative outcomes, and midterm results of carotid artery stenting (CAS) performed with the Roadsaver/Casper stent (Terumo Corp, Tokyo, Ja...

Neutrophil Counts Help Predict Free Wall Rupture Following St-elevation Myocardial Infarction.

Jun 24, 2021

Free wall rupture (FWR) is a lethal complication after acute myocardial infarction; however, the un-derlying mechanisms of FWR are unclear. This study analyzes the relationship between neutrophil coun...

Intraoperative gram staining of bile for the prevention of infectious complications in pancreaticoduodenectomy.

Jun 24, 2021

Infectious complications play a prominent role in pancreaticoduodenectomy. Their incidence increases in cases with preoperative biliary drainage (PBD), due to the higher risk of bacterobilia. The aim ...

Appropriateness of empirical antibiotic therapy and added value of adjunctive gentamicin in patients with septic shock: a prospective cohort study in the ICU.

Jun 24, 2021

To determine the appropriateness of empiric antibiotic therapy and the possible benefit of adding short-course gentamicin in septic shock patients with abdominal, urogenital, or an unknown focus. Seco...

Long-term Outcomes after Seton Placement for Perianal Fistulae with and without Crohn's Disease.

Jun 24, 2021

Perianal sepsis in Crohn's fistulae is managed with antibiotics and surgical drainage; a non-cutting seton is used for an identified trans-sphincteric fistula tract. Optimal management following seton...

Sensitivity and specificity of the INECO frontal screening (IFS) in the detection of patients with traumatic brain injury presenting executive deficits.

Jun 24, 2021

Executive dysfunction (EF) is a common feature of adult traumatic brain injury (TBI), especially in moderate to severe cases. Assessing EF usually requires the administration of an extensive neuropsyc...

A meta-analysis of cohort studies: Traumatic brain injury and risk of Alzheimer's Disease.

Jun 24, 2021

Recently, some epidemiological studies have reported that cognitive disorders in elderly people is accelerated with traumatic brain injury. But the causal relationship between traumatic brain injury a...

The timeframe for safe resumption of high-level mobility following traumatic brain injury is currently unknown: a systematic review.

Jun 24, 2021

To examine the safety of high-level mobility (HLM) prescription in the early sub-acute phase of recovery following moderate-to-extremely severe traumatic brain injury (TBI) with specific focus on prov...

Statin associated lower cancer risk and related mortality in patients with heart failure.

Jun 24, 2021

Patients with heart failure (HF) have an increased risk of incident cancer. Data relating to the association of statin use with cancer risk and cancer-related mortality among patients with HF are spar...

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