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Critical Care General

The Role of Thyroid Hormone in Neuronal Protection.

Jun 03, 2021

Thyroid hormone is essential for brain development and brain function in the adult. During development, thyroid hormone acts in a spatial and temporal-specific manner to regulate the expression of gen...

The relationship between brain injury criteria and brain strain across different types of head impacts can be different.

Jun 03, 2021

Multiple brain injury criteria (BIC) are developed to quickly quantify brain injury risks after head impacts. These BIC originated from different head impact types (e.g. sports and car crashes) are wi...

Wakefulness-promoting effects of lateral hypothalamic area deep brain stimulation in traumatic brain injury-induced comatose rats: Upregulation of α1-adrenoceptor subtypes and downregulation of gamma-aminobutyric acid b receptor expression via the orexins pathway.

Jun 03, 2021

Previous studies have shown that deep brain stimulation can improve the levels of consciousness of comatose patients with traumatic brain injuries (TBIs). However, the most suitable targets for deep b...

Complex functionality of protein phosphatase 1 isoforms in the heart.

Jun 03, 2021

Protein phosphatase 1(PP1) is a key regulator of cardiac function through dephosphorylating serine/threonine residues within target proteins to oppose the function of protein kinases. Studies from fai...

Non-alcoholic Steatohepatitis and HCC in a Hyperphagic Mouse Accelerated by Western Diet.

Jun 03, 2021

How benign liver steatosis progresses to non-alcoholic steatohepatitis (NASH), fibrosis and hepatocellular carcinoma (HCC) remains elusive. NASH progression entails diverse pathogenic mechanisms and r...

evaluation of two adaptive Starling-like control algorithms for left ventricular assist devices.

Jun 03, 2021

The implantation of a left ventricular assist device (LVAD) is often the only therapy in terminal heart failure (HF). However, despite technical advancements, the physical fitness of the patients is s...

The Influence of the COVID-19 Pandemic on ICU Organization, Care Processes, and Frontline Clinician Experiences: A Qualitative Study.

Jun 03, 2021

The COVID-19 pandemic resulted in unprecedented adjustments to intensive care unit (ICU) organization and care processes globally.Did hospital emergency responses to the COVID-19 pandemic differ depen...

Covid-19 and Athletes: To Screen or Not to Screen for Myocarditis

Jun 01, 2021

Most screened athletes had subclinical infection, study found Myocarditis can be confirmed in one of two ways, endovascular biopsy or cardiac magnetic resonance imaging (CMR); the first option is i...

THE EFFECT OF CARBON MONOXIDE RELEASING MOLECULE-2 ON HEALING OF ISCHEMIC COLON ANASTOMOSIS IN RATS.

May 31, 2021

Ischemia on the colon wall negatively affects healing of anastomosis. We were aimed to evaluate the effects of Carbon Monoxide Releasing Molecule-2 (CORM-2) on the healing of anastomosis in a rat mode...

Hepatoprotective effect of anemoside B4 against sepsis-induced acute liver injury through modulating the mTOR/p70S6K-mediated autophagy.

May 31, 2021

Sepsis triggers liver dysfunction with high morbidity and mortality. Here, we elucidated the effect of anemoside B4 on sepsis in cecal ligation and puncture (CLP)-induced mouse model and LPS-induced p...

Readmission after epilepsy monitoring unit discharge in a nationally representative sample.

May 31, 2021

To determine the 30-day readmission rate after Epilepsy Monitoring Unit (EMU) discharge in a nationally representative sample, as well as patient, clinical, and hospital characteristics associated wit...

Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia.

May 31, 2021

Immune profiling of COVID-19 patients has identified numerous alterations in both innate and adaptive immunity. However, whether those changes are specific to SARS-CoV-2 or driven by a general inflamm...

Mechanisms of Immunothrombosis in Vaccine-Induced Thrombotic Thrombocytopenia (VITT) Compared to Natural SARS-CoV-2 Infection.

May 31, 2021

Herein, we consider venous immunothrombotic mechanisms in SARS-CoV-2 infection and anti-SARS-CoV-2 DNA vaccination. Primary SARS-CoV-2 infection with systemic viral RNA release (RNAaemia) contributes ...

P2Y12 Inhibitors Plus Aspirin Versus Aspirin Alone in Patients With Minor Stroke or High-Risk Transient Ischemic Attack.

May 31, 2021

We performed a systemic review and meta-analysis to elucidate the effectiveness and safety of dual antiplatelet (DAPT) therapy with P2Y12 inhibitors (clopidogrel/ticagrelor) and aspirin versus aspirin...

A Case of Periprosthetic Joint Infection Because of Rothia Mucilaginosa.

May 31, 2021

Periprosthetic joint infection (PJI) is a rare but devastating complication of total joint arthroplasty. Identifying the offending infectious agent is essential to appropriate treatment, and uncommon ...

A Ten-year Surveillance of P. aeruginosa Bloodstream Infections in a Tertiary Care Hospital: Trends and Risk Factors for Mortality.

May 31, 2021

Pseudomonas aeruginosa (P. aeruginosa) is a leading cause of nosocomial bloodstream infections worldwide. This study aimed to evaluate the incidence of P. aeruginosa bloodstream infections and to iden...

All-trans-retinoic acid restores CD4+ T cell response after sepsis by inhibiting the expansion and activation of myeloid-derived suppressor cells.

May 31, 2021

Patients are susceptible to immunosuppression in late-stage of sepsis, in which myeloid-derived suppressor cells (MDSCs) is an important contributor. This study aims to investigate whether all-trans-r...

Prevalence of Polytrauma Clinical Triad Among Active Duty Service Members.

May 31, 2021

The polytrauma clinical triad (PCT), encompassing traumatic brain injury, PTSD, and chronic pain, has been identified as a significant concern in the Military Health System (MHS). Conditions in this t...

A review of external lumbar drainage for the management of intracranial hypertension in traumatic brain injury.

May 31, 2021

The Brain Trauma Foundation (BTF) published evidence-based guidelines with a detailed approach to the management of intracranial hypertension (ICH) in traumatic brain injury (TBI) patients. However, m...

Risk factors and predictors of QTc prolongation in critically ill Chinese patients.

May 31, 2021

To recognize and validate the predictor of risk factors for ICU patients with QTc intervals ≥500 ms.We retrospectively reviewed 160 ICU patients with their medical electronic records including all d...

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