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Critical Care General

Withdrawal of active treatments in terminally ill heart failure patients.

May 10, 2021

Heart failure (HF) constitutes a growing public health problem in aging societies: when pharmacological therapies fail, HF can be sustained intensively if patients are eligible for either orthotopic h...

The role of PP5 and PP2C in cardiac health and disease.

May 10, 2021

Protein phosphatases are important, for example, as functional antagonists of β-adrenergic stimulation of the mammalian heart. While β-adrenergic stimulations increase the phosphorylation state of r...

Limiting Brain Shift in Malignant Hemispheric Infarction by Decompressive Craniectomy.

May 06, 2021

Decompressive craniectomy (DC) improves functional outcomes in selected patients with malignant hemispheric infarction (MHI), but variability in the surgical technique and occasional complications may...

Extensive subcutaneous fat necrosis complicated by neonatal hypercalcaemia.

May 06, 2021

subcutaneous fat necrosis is a benign and often self-limiting inflammatory disorder experienced by newborns who were exposed to perinatal stress in the form of asphyxia, hypothermia, cord prolapse, an...

Comprehensive metabolic amino acid flux analysis in critically ill patients.

May 06, 2021

Amino acid (AA) metabolism is severely disturbed in critically ill ICU patients. To be able to make a more scientifically based decision on the type of protein or AA nutrition to deliver in ICU patien...

COVID-19-related coagulopathy: a review of pathophysiology and pharmaceutical management.

May 06, 2021

December 2019 will never be forgotten in the history of medicine when an outbreak of pneumonia of unknown etiology in Wuhan, China sooner or later prompted the World Health Organization (WHO) to issue...

Cardiac Surgery Outcomes: A Case for Increased Screening and Treatment of Obstructive Sleep Apnea.

May 06, 2021

Due to the limited published information on complications that obstructive sleep apnea (OSA) patients experience during and after cardiac surgery, we are investigating OSA as a risk factor for post-op...

Upregulated-gene expression of pro-inflammatory cytokines, oxidative stress and apoptotic markers through inflammatory, oxidative and apoptosis mediated signaling pathways in bovine pneumonia.

May 06, 2021

Pneumonia is the acute inflammation of lung tissue and is multi-factorial in etiology. Staphylococcus aureus (S. aureus) is a harmful pathogen present as a normal flora of skin and nares of dairy catt...

Serum Phosphate and 1-Year Outcome in Patients With Acute Ischemic Stroke and Transient Ischemic Attack.

May 06, 2021

To determine the association between serum phosphate level and 1-year clinical outcomes in patients with acute ischemic stroke and transient ischemic attack. We included 7,353 patients with acute is...

A severity-of-illness score in patients with tuberculosis requiring intensive care.

May 06, 2021

We previously retrospectively validated a 6-point severity-of-illness score aimed at identifying patients at risk of dying of tuberculosis (TB) in the intensive care unit (ICU). Parameters included se...

Pneumococcal septic shock after neonatal respiratory syncytial virus bronchiolitis: A case report and literature review.

May 06, 2021

Bronchiolitis is a common cause of hospitalisation of infants less than a year old, with most infants recovering without complications. Respiratory syncytial virus (RSV) is a leading cause of bronchio...

Pediatric Acetabular Osteomyelitis Treated With Hip Arthroscopy.

May 06, 2021

Osteomyelitis of the acetabulum is a rare condition accounting for only 12% of pelvic osteomyelitis cases. This report describes a previously healthy 10-year-old girl with subacute acetabular osteomye...

The pleiotropic of GLP-1/GLP-1R axis in central nervous system diseases.

May 06, 2021

Glucagon-like peptide-1(GLP-1) is a multifunctional polypeptide throughout the lifespan via activating Glucagon-like peptide-1 receptor (GLP-1R).GLP-1 can affect food ingestion, enhance the secretion ...

Comparative analysis of spreading depolarizations in brain slices exposed to osmotic or metabolic stress.

May 06, 2021

Recurrent spreading depolarizations (SDs) occur in stroke and traumatic brain injury and are considered as a hallmark of injury progression. The complexity of conditions associated with SD in the livi...

Microwave scan and brain biomarkers to rule out intracranial hemorrhage: study protocol of a planned prospective study (MBI01).

May 06, 2021

The aim of this planned study is to evaluate the ability of a cranial microwave scanner in conjunction with nine brain biomarkers (Aβ40, Aβ42, GFAP, H-FABP, S100B, NF-L, NSE, UCH-L1 and IL-10) to de...

Urgent-start dialysis in patients referred early to a nephrologist-the CKD-REIN prospective cohort study.

May 06, 2021

The lack of a well-designed prospective study of the determinants of urgent dialysis start led us to investigate its individual- and provider-related factors in patients seeing nephrologists.CKD-REIN ...

Social and environmental risks as contributors to the clinical course of heart failure.

May 06, 2021

Heart failure is a major contributor to healthcare expenditures. Many clinical risk factors for the development and exacerbation of heart failure had been reported, including diabetes, renal dysfuncti...

Nanoparticle conjugation of ginsenoside Rb3 inhibits myocardial fibrosis by regulating PPARα pathway.

May 06, 2021

Cardiac fibrosis occurs in ischemic and non-ischemic heart failure, hereditary cardiomyopathy, diabetes and aging. Energy metabolism, which serves a crucial function in the course and treatment of car...

Bone marrow mesenchymal stem cells-derived extracellular vesicles carrying microRNA-221-3p protect against ischemic stroke via ATF3.

May 03, 2021

We aim to explore the protective effect of bone marrow mesenchymal stem cells (BMSCs)-derived exosomal microRNA-221-3p (miR-221-3p) on ischemic stroke (IS) by targeting activating transcription factor...

Brain MRI after therapeutic hypothermia in asphyxiated newborns: Predictive value at one year of imaging features.

May 03, 2021

To compare early brain MRI using a composite imaging score and outcome at one year in asphyxiated newborns treated by hypothermia.This retrospective study included for two years consecutive asphyxiate...

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