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Critical Care General

Fibrinolysis in Traumatic Brain Injury: Diagnosis, Management, and Clinical Considerations.

Apr 22, 2021

Posttraumatic coagulopathy involves disruption of both the coagulation and fibrinolytic pathways secondary to tissue damage, hypotension, and inflammatory upregulation. This phenomenon contributes to ...

Tranexamic Acid Treatment for Trauma Victims.

Apr 22, 2021

Worldwide, traumatic injury is responsible for over 5 million deaths per year, the majority due to exsanguination and head injury. The antifibrinolytic drug tranexamic acid is the only drug proven to ...

Clinical and economic outcomes of a collaborative cardiology care program.

Apr 22, 2021

We evaluated a collaborative care program aimed at improving cooperation among general practitioners (GPs) and cardiologists in Baden-Wuerttemberg, Germany. The program focused on improving care for p...

Hematocrit-Related Alterations of Circulating microRNA-21 Levels in Heart Failure Patients with Reduced Ejection Fraction: A Preliminary Study.

Apr 22, 2021

Circulating microRNA-21 (miR-21) has been utilized as a diagnostic tool in the assessment of heart failure (HF). Blood constitution may be altered when HF occurs and miR-21 may affect hematopoiesis. ...

In vitro model of ischemic heart failure using human induced pluripotent stem cell-derived cardiomyocytes.

Apr 22, 2021

Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) have been used extensively to model inherited heart diseases, but hiPSC-CM models of ischemic heart disease are lacking. Here our...

The evolving role of coronary CT angiography in Acute Coronary Syndromes.

Apr 19, 2021

In the United States, non-obstructive coronary disease has been on the rise, and each year, nearly one million adults suffer myocardial infarction, 70% of which are non-ST-segment elevation myocardial...

Intraoperative EEG Changes During TCAR are more Frequent than Previously Reported.

Apr 19, 2021

Up to 14% of patients undergoing carotid endarterectomy (CEA) with continuous electroencephalographic (EEG) neuromonitoring require shunt placement due to EEG changes. Initial studies of transcarotid ...

Long-Term Outcomes of Stroke or Transient Ischemic Attack after Non-Emergency Percutaneous Coronary Intervention.

Apr 19, 2021

Non-emergency percutaneous coronary intervention (PCI) has lower risk of stroke than emergency PCI. With increasing elective PCI and increasing risk of stroke after PCI, risk factors for stroke or tra...

Hospital-acquired infections in critically-ill COVID-19 patients.

Apr 19, 2021

Few small studies have described hospital-acquired infections (HAIs) during COVID-19.What patient characteristics in critically ill patients with COVID-19 are associated with HAIs and how do HAIs asso...

Real-World Experience with Artificial Intelligence-Based Triage in Transferred Large Vessel Occlusion Stroke Patients.

Apr 15, 2021

Randomized controlled trials have demonstrated the importance of time to endovascular therapy (EVT) in clinical outcomes in large vessel occlusion (LVO) acute ischemic stroke. Delays to treatment are ...

Antithrombotic Management in Ischemic Stroke with Essential Thrombocythemia: Current Evidence and Dilemmas.

Apr 15, 2021

Thrombotic diseases like ischemic stroke are common complications of essential thrombocythemia (ET) due to abnormal megakaryopoiesis and platelet dysfunction. Ischemic stroke in ET can occur as a resu...

The "Flying Intervention Team": A Novel Stroke Care Concept for Rural Areas.

Apr 15, 2021

Endovascular treatment of large vessel occlusion in acute ischemic stroke patients is difficult to establish in remote areas, and time dependency of treatment effect increases the urge to develop heal...

De Ritis Ratio as a Significant Prognostic Factor in Patients with Sepsis: A Retrospective Analysis.

Apr 15, 2021

This study was performed to investigate the relationship between the aspartate transaminase and/or alanine transaminase ratio (DRR) and long-term mortality of patients diagnosed with sepsis or septic ...

Moderating Effects of Race and Preoperative Comorbidity on Surgical Mortality in Infants.

Apr 15, 2021

We sought to investigate the risk of pediatric surgical mortality associated with the combined effects of key preoperative comorbidities and race.We performed a retrospective study that included infan...

Antibiotics in treatment of COVID-19 complications: a review of frequency, indications, and efficacy.

Apr 15, 2021

To report available information in the literature regarding frequency, indications, types of antibiotic usage, duration, and their efficacy in Covid-19 infected patients.The search was conducted on Ap...

A Before-and-After Study of Evidence-Based Recommendations for On-Call Bronchoscopy.

Apr 15, 2021

Bronchoscopy is widely used and regarded as standard of care in most intensive care units (ICUs). Data concerning recommendations for on-call bronchoscopy are lacking.Evaluation of recommendations, co...

Detection of Myocardial Infarction by Cardiac Magnetic Resonance in Embolic Stroke Related to First Diagnosed Atrial Fibrillation.

Apr 15, 2021

Elevated troponin levels are found in a significant number of patients who are diagnosed with acute embolic stroke (AES) after first diagnosed atrial fibrillation (AF). These myocardial injuries, whic...

External stenting of vein grafts in coronary artery bypass grating: interim results from a two centers prospective study.

Apr 15, 2021

previous studies evaluating external stents for saphenous vein grafts (SVG) in CABG were limited to on-pump isolated CABG and single grafting technique with one external stent per patient. The objecti...

Prophylactically injection of Nicorandil to reduce no-reflow phenomenon during PCI in acute STEMI patients: Protocol of a double-blinded, randomized, placebo-controlled trial.

Apr 15, 2021

An acute ST-elevation myocardial infarction (STEMI) is a very serious type of heart attack and a profoundly life-threatening medical emergency, and percutaneous coronary intervention (PCI) is the pref...

Role of Mitochondria-Derived Danger Signals Released after Injury in Systemic Inflammation and Sepsis.

Apr 15, 2021

Sepsis is a major public health concern, with high mortality and morbidity, especially among trauma patients. It is characterized by a systemic inflammatory response syndrome (SIRS) occurring in respo...

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