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Critical Care General

Effect of Carillon Mitral Contour System on patient-reported outcomes in functional mitral regurgitation: an individual participant data meta-analysis.

Apr 01, 2021

The Carillon Mitral Contour System has been shown to reduce mitral regurgitation and left ventricular volumes in symptomatic heart failure patients with functional mitral regurgitation. We sought to e...

Impact of Intoxicants on Patients With Burn-Related Injuries

Mar 30, 2021

“The use of nicotine, alcohol, and illicit substances, alone or in combination, may predispose patients with burn injuries to poor outcomes and complications in a hospital setting,” explains Kevin...

The Effects of Multimodal Analgesia in Critically Ill Patients With Burns

Mar 29, 2021

Pain from burn injuries can be challenging to treat and remains one of the most severe forms of trauma a patient can endure, explains Sierra R. Young, PharmD, BCCCP.  “Patients with burn injuries e...

Gypenoside XLIX protects against acute kidney injury by suppressing IGFBP7/IGF1R-mediated programmed cell death and inflammation.

Mar 29, 2021

Acute kidney injury (AKI), characterised by excessive inflammatory cell recruitment and programmed cell death, has a high morbidity and mortality; however, effective and specific therapies for AKI are...

Immediate Postoperative Electroencephalography Monitoring in Pediatric Moyamoya Disease and Syndrome.

Mar 29, 2021

Moyamoya disease and syndrome are progressive steno-occlusive cerebrovascular diseases that manifest clinically with ischemic episodes. There is evidence for the use of electroencephalography (EEG) in...

Hydrogen gas alleviates sepsis-induced neuroinflammation and cognitive impairment through regulation of DNMT1 and DNMT3a-mediated BDNF promoter IV methylation in mice.

Mar 29, 2021

Sepsis-associated encephalopathy (SAE) can cause acute and long-term cognitive impairment and increase the mortality rate in sepsis patients, and we previously reported that 2% hydrogen gas (H) inhala...

Maternal temperature in emergency caesarean section (MATES): an observational multicentre study.

Mar 29, 2021

Temperature regulation in women undergoing emergency caesarean section is a complex topic about which there is a paucity of evidence-based recommendations. The adverse effects of inadvertent peri-oper...

Evaluation of ventilator associated events in critically ill patients with invasive mechanical ventilation: A prospective cohort study at a resource limited setting in Northern India.

Mar 29, 2021

The primary aim of this study was to identify the modifiable risk factors for acquiring ventilator associated events (VAE). Secondary aims were to investigate the intensive care unit (ICU) course and ...

Accuracy of Chest CT for Differentiating COVID-19 from COVID-19 Mimics.

Mar 29, 2021

 To determine the performance of radiologists with different levels of expertise regarding the differentiation of COVID-19 from other atypical pneumonias. Chest CT to identify patients suffering fro...

Development of COVID-19 vaccines utilizing gene therapy technology.

Mar 29, 2021

There is currently an outbreak of respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Coronavirus disease 2019 (COVID-19) is caused by infection with SARS-CoV-2...

Risk prediction of bleeding and MACCE by PRECISE-DAPT score post-PCI.

Mar 29, 2021

Guidelines recommend the PRECISE-DAPT (PD) score to adapt duration of dual antiplatelet therapy due to bleeding risk. However, there is first evidence that PD predicts mortality and ischemic events as...

Exosomes protect against acute myocardial infarction in rats by regulating the renin angiotensin system.

Mar 29, 2021

The renin angiotensin system (RAS) has been suggested to play an important role in cardiac remodeling after acute myocardial infarction(AMI). We have confirmed that bone marrow mesenchymal stem cell-d...

An evaluation of sepsis in dentistry.

Mar 29, 2021

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. It is a major health concern and causes substantial morbidity and mortality. It is imperative that t...

Enhanced antibiotic prophylaxis and infection-related complications following prostate biopsy.

Mar 29, 2021

Sepsis after prostate biopsy is a costly and potentially lethal complication. We sought to assess whether enhanced antibiotic prophylaxis regimens combining oral and parenteral antibiotics may decreas...

Certified Athletic Trainers' Use of Cervical Clinical Testing in the Diagnosis and Management of Sports-Related Concussion.

Mar 29, 2021

Despite evidence implicating cervicogenic symptoms in the development of persistent postconcussion symptoms, factors that influence utilization of cervical clinical tests to identify cervicogenic symp...

Spatial calcium kinetics after a traumatic brain injury.

Mar 29, 2021

Accurate modelling of intracellular calcium ion ([Formula: see text]) concentration evolution is valuable as it is known to rapidly increase during a Traumatic Brain Injury. In the work presented here...

Enriching neural stem cell and anti-inflammatory glial phenotypes with electrical stimulation after traumatic brain injury in male rats.

Mar 29, 2021

Traumatic brain injury (TBI) by an external physical impact results in compromised brain function via undesired neuronal death. Following the injury, resident and peripheral immune cells, astrocytes, ...

Asenapine maleate inhibits angiotensin II-induced proliferation and activation of cardiac fibroblasts via the ROS/TGFβ1/MAPK signaling pathway.

Mar 29, 2021

Cardiac fibrosis will increase wall stiffness and diastolic dysfunction, which will eventually lead to heart failure. Asenapine maleate (AM) is widely used in the treatment of schizophrenia. In the cu...

Relationship between paced QRS duration and myocardial relaxation of the left ventricle in patients with chronic right ventricular apical pacing.

Mar 29, 2021

Right ventricular (RV) apical pacing is associated with systolic dysfunction and heart failure. Paced QRS duration has been suggested as a predictor of heart failure and left ventricular (LV) systolic...

Coagulation Factors Accumulate During Normothermic Liver Machine Perfusion Regardless of Donor Type and Severity of Ischemic Injury.

Mar 25, 2021

Coagulation factors may inform on liver function during normothermic machine perfusion (NMP). We investigated whether graft ischemic injury impairs the accumulation of (anti)coagulation factors during...

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