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Critical Care General

Pathophysiology of sepsis.

Mar 04, 2021

To provide a current overview of sepsis pathophysiology.The emphasis on sepsis pathophysiology has moved away from the pathogen - the initiating factor - and instead is focussed upon the abnormal and ...

Protective Effects of Aquaporin-4 Deficiency on Longer-term Neurological Outcomes in a Mouse Model.

Mar 04, 2021

Traumatic brain injury (TBI) has been a crucial health problem, with more than 50 million patients worldwide each year. Glymphatic system is a fluid exchange system that relies on the polarized water ...

Improving transition from inpatient rehabilitation following traumatic brain injury:Protocol for the BRITE pragmatic comparative effectiveness trial.

Mar 04, 2021

Moderate to severe traumatic brain injury (TBI) is a common cause of long-term disability. Due to challenges that include inconsistent access to follow-up care, persons with TBI being discharged from ...

Posttraumatic Stress Disorder Subsequent to Apparent Mild Traumatic Brain Injury.

Mar 04, 2021

Posttraumatic stress disorder (PTSD) is prevalent among veterans with a history of traumatic brain injury (TBI); however, the relationship between TBI and PTSD is not well understood. We present the c...

Management of rhythm disorders in Duchenne muscular dystrophy: Is sudden death a cardiac or pulmonary problem?

Mar 04, 2021

Dystrophin deficiency results in the cardiomyopathy of variable onset and deficiency. Myocardial scarring commonly results in cardiac dysfunction, with both atrial and ventricular dysrhythmias. Heart ...

The role of imaging in characterizing the cardiac natural history of Duchenne muscular dystrophy.

Mar 04, 2021

Duchene muscular dystrophy (DMD) is a rare but devastating disease resulting in progressive loss of ambulation, respiratory failure, DMD-associated cardiomyopathy (DMD-CM), and premature death. The us...

Toll-like receptor 2 signaling deficiency in cardiac cells ameliorates Ang II-induced cardiac inflammation and remodeling.

Mar 04, 2021

Activation of the innate immune system represents a vital step in inflammation during cardiac remodeling induced by the angiotensin II (Ang II). This study aimed to explore the role of Toll-like recep...

The burden of mental illness among survivors of critical care - risk factors and impact on quality of life: a multicenter prospective cohort study.

Mar 04, 2021

Survivors of critical care may develop mental health disorders in the months after discharge.Which are risk factors for mental health disorders after ICU-discharge; and is there association between th...

Assessing Perioperative Multimodal Analgesia in Patients With Burns

Mar 03, 2021

Postoperative pain has been shown in prior research to be a major challenge for patients with burns who undergo autologous skin grafting. Burn injuries cause severe pain, with many patients requiring ...

Have you experienced...

Mar 03, 2021

“Have you experienced hearing and vision loss or difficulty speaking?” ...

Intraoperative bronchial blood flow evaluation using indocyanine green fluorescence for bronchoplasty: A case report.

Mar 01, 2021

Blood flow evaluation of bronchial arteries using indocyanine green fluorescence (ICG-FL) is rarely reported during pulmonary resection. We present the case of a patient with bronchiectasis and a hist...

Neuroprotection of Chikusetsu saponin V on transient focal cerebral ischemia/reperfusion and the underlying mechanism.

Mar 01, 2021

Oxidative stress and frequently unwanted alterations in mitochondrial structure and function are key aspects of the pathological cascade in transient focal cerebral ischemia. Chikusetsu saponin V (CHS...

HeMA: A hierarchically enriched machine learning approach for managing false alarms in real time: A sepsis prediction case study.

Mar 01, 2021

Early detection of sepsis can be life-saving. Machine learning models have shown great promise in early sepsis prediction when applied to patient physiological data in real-time. However, these existi...

Hydrogen Gas Therapy Attenuates Inflammatory Pathway Signaling in Septic Mice.

Mar 01, 2021

Molecular hydrogen (H) has been used in clinical cases. However, there are few studies of H therapy to treat sepsis, and anti-inflammatory mechanisms of H are mostly unknown. We aimed to confirm effec...

Laparoscopic lymph node sampling: a new concept for patients with high-risk early esophagogastric junction cancer resected endoscopically.

Mar 01, 2021

Endoscopic resection is considered as curative treatment for early upper GI cancers under certain histologic (low-risk) criteria. In tumors not completely fulfilling these criteria but resected R0 end...

Persistent psychopathology and neurocognitive impairment in COVID-19 survivors: effect of inflammatory biomarkers at three-month follow-up.

Mar 01, 2021

COVID-19 outbreak is associated with mental health implications during viral infection and at short-term follow-up. Data on psychiatric and cognitive sequelae at medium-term follow-up are still lackin...

Bovine respiratory coronavirus enhances bacterial adherence by upregulating expression of cellular receptors on bovine respiratory epithelial cells.

Mar 01, 2021

Bovine coronavirus (BCoV) is one of the agents causing bovine respiratory disease complex (BRDC), with single infection tending to be mild to moderate; the probability of developing pneumonia in BRDC ...

Mitochondrial respiration in C57BL/6 substrains varies in response to myocardial infarction.

Mar 01, 2021

The C57BL/6 mouse strain have been commonly used for the genetic background animal models and experimental research. There are several major sources of C57BL/6 substrains for the biomedical research c...

Cateslytin abrogates lipopolysaccharide-induced cardiomyocyte injury by reducing inflammation and oxidative stress through toll like receptor 4 interaction.

Mar 01, 2021

Global public health is threatened by new pathogens, antimicrobial resistant microorganisms and a rapid decline of conventional antimicrobials efficacy. Thus, numerous medical procedures become life-t...

Toll Like receptor 4 antagonist FP7 alleviates lipopolysaccharide-induced septic shock via NF-kB signaling pathway.

Mar 01, 2021

Septic shock is the most severe complication of sepsis occurs when body has an overwhelming response to infection, making it the most prevalent cause of deaths in surgical intensive-care units. Theref...

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