Intravenous tenecteplase non-inferior to alteplase for thrombolysis in acute ischemic stroke
1. IV tenecteplase was non-inferior to IV alteplase for treatment of acute ischemic stroke...
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Emergency
Racial and ethnic discrepancies in pulse oximetry performance associated with reduced oxygen supplementation
1. This retrospective cohort study demonstrated that for a given blood oxygen hemoglobin...
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Adjuvant erythropoietin therapy does not improve survival in newborns with hypoxic-ischemic encephalopathy
1. Erythropoietin administration did not lower the risk of death or neurodevelopmental impairment...
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Thrombectomy alone is inferior to thrombectomy plus alteplase for acute ischemic stroke
1. Fewer patients in the thrombectomy group achieved an MRS score of 0-2 at 90 days compared to...
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Bridging therapy is superior to direct thrombectomy within 4.5 hours of acute ischemic stroke
1. Fewer patients in the direct thrombectomy achieved functional independence at 90 days compared...
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Age-based products and longer interdose intervals may reduce the risk of cardiac disease following COVID-19 mRNA vaccination
1. This study found that most cases of myocarditis or pericarditis following COVID-19 mRNA...
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APOEε4 genotype may increase risk of chronic traumatic encephalopathy following repetitive head impact
1. A cross sectional study of postmortem brain specimens from individuals with a history of...
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Intravenous fluid restriction does not improve septic shock outcomes
1. There was no significant difference in mortality among septic shock patients in the intensive...
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Spinal anesthesia for hip fracture surgery associated with increased pain and analgesic use
1. Spinal anesthesia, as compared with general anesthesia, was associated with a small but...
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Intravenous vitamin C increases mortality and organ dysfunction in sepsis patients
1. In patients with sepsis receiving a vasopressor in the intensive care unit (ICU), intravenous...
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CYP2C19 loss-of-function carriers have modest benefit from ticagrelor and aspirin following cerebrovascular event: CHANCE-2 Trial
1. Patients carrying the CYP2C19 loss-of-function mutation (C-LOF), who had experienced a minor...
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Incidence of Kawasaki disease found to be lower during the COVID-19 pandemic in the United States
1. This multicenter cohort study of 3922 children with Kawasaki disease (KD) demonstrated that...
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Albuterol-budesonide combination efficacious for asthma exacerbation rescue
1. A high-dose combination inhaler of albuterol and budesonide was superior to albuterol alone in...
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Social risk factors associated with increased pediatric emergency department utilization
1. In a large cohort of children screened for risk factors such as food insecurity and housing...
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#VisualAbstract: CT Associated With Lower Complication Risks than Invasive Coronary Angiography
1. In patients with stable chest pain and intermediate pretest probability of coronary artery...
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High pediatric sequential organ failure assessment (pSOFA) score may predict hospital mortality in emergency department setting
1. In a large cohort study, children presenting to emergency departments with a score of 2 or...
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Awake prone positioning does not seem to offer benefit in reducing endotracheal intubation for COVID-19-induced acute respiratory failure: COVI-PRONE trial
1. This randomized clinical trial demonstrated no difference in the risk of endotracheal...
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Canadian Syncope Risk Score demonstrates international external validation
1. The Canadian Syncope Risk Score was superior when compared to the Osservatorio Epidemiologico...
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Risks associated with nonoperative management of uncomplicated pediatric appendicitis
1. In a retrospective cohort study of approximately 73,000 children...
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Awake prone positioning may not offer clinical benefits among patients hospitalized with COVID-19-associated hypoxemia
1. In this non-randomized controlled trial including 501 patients with COVID-19-associated...
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