Prolonged β-Lactam Antibiotic Infusions Aid Sepsis and Septic Shock Outcomes
Among adults with sepsis or septic shock in the ICU, the use of prolonged β-lactam antibiotic infusions is associated with a lower risk of 90-day mortality.
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Emergency
Intravenous tenecteplase shows no benefit in minor ischemic stroke with intracranial occlusion
1. Return to baseline function was comparable in tenecteplase and standard-of-care groups. 2. More...
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Reteplase Shows Better AIS Treatment Functional Outcomes Than Alteplase, but Higher Intracranial Hemorrhage Rates
1. In a randomized controlled trial of patients who suffered an acute ischemic stroke, the...
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Pantoprazole Decreases Risk of Upper GI Bleeding in Mechanically Ventilated Patients
1. In this randomized controlled trial studying critically ill adults, pantoprazole use was...
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Oral sebetralstat provides early symptom relief for hereditary angioedema attacks
1. In this randomized controlled trial, oral sebetralstat provided faster times to the beginning...
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Preoxygenation with noninvasive ventilation reduces hypoxemia during intubation
1. In this randomized controlled trial involving critically ill adults undergoing tracheal...
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Artificial intelligence may improve the accuracy of physicians’ electroencephalogram interpretations
1. A cross-over study compared clinicians’ electroencephalogram (EEG) interpretation accuracy with...
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Endoscopic Evacuation and Stereotactic Aspiration Superior to Craniotomy for Intracerebral Hemorrhage Treatment Outcomes
1. Treating intracerebral hemorrhage (ICH) with endoscopic evacuation or stereotactic aspiration...
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Quantifying the increased mortality associated with delayed antibiotics in pediatric sepsis
1. Administration of antibiotics beyond 330 minutes from emergency department arrival in pediatric...
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Andexanet reduces hematoma expansion in factor Xa inhibitor-associated intracerebral hemorrhage
1. In this randomized controlled trial, among patients presenting with acute intracerebral...
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Early blood-pressure control not associated with improved outcomes in patients with undifferentiated stroke
1. In this randomized controlled trial, patients with stroke symptoms who were given...
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No benefit to fractional flow reserved-guided revascularization in myocardial infarction
1. In this randomized controlled trial, compared to culprit-lesion-only percutaneous coronary...
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Empagliflozin does not decrease risk of hospitalization or death after myocardial infarction
1. In this randomized controlled trial, empagliflozin was not shown to decrease the risk of...
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Decompressive Craniectomy May Benefit Patients With Supratentorial Intracerebral Hemorrhage
1. Fewer patients in the decompressive craniectomy group had an mRS score of 5-6 compared to...
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Nirmatrelvir does not decrease symptom duration in COVID-19
1. In this randomized controlled trial, there was no difference in the median time to sustained...
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Endovascular thrombectomy associated with improved cognitive outcomes for acute ischemic stroke at 5 months
1. In post-stroke patients, endovascular thrombectomy (EVT) was associated with favourable...
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Large language models may be effective in assessing clinical acuity of adult patients in the emergency department
1. The large language model, GPT-4, was capable of assessing clinical acuity when presented with...
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Microaxial flow pump improves infarct-related cardiogenic shock outcomes
1. In this randomized controlled trial, in patients with infarct-relate cardiogenic shock, death...
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Minimally invasive surgery provides functional benefit in acute supratentorial intracerebral hemorrhage
1. In this randomized controlled trial, patients who underwent minimally invasive surgical...
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Endovascular Thrombectomy Post-Large-Vessel Ischemic Stroke Lowers Mortality & Improves Functional Outcomes
Patients in the thrombectomy plus medical care group reported a significantly lower mRS score at...
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